Blood-brain barrier leakage as a predictive factor for post-stroke epilepsy

Post-stroke epilepsy (PSE) is a major complication after stroke, which remains difficult to predict. Management of PSE can be challenging, as underlying mechanisms and optimal treatment are undetermined. Blood-brain barrier (BBB) dysfunction has been associated with the development of PSE, though the exact course and consequence of disturbed permeability in

epileptogenesis are unclear. Our aims are to elucidate the relationship between BBB permeability and PSE, and to identify potential (imaging) biomarkers for early identification of patients at risk for PSE. To that aim we will apply MRI to characterize the spatiotemporal dynamics and effects of BBB permeability in relation to the development of PSE in stroke patients, and further elucidate pathophysiological traits and mechanisms thereof in a rat stroke model. This translational project will provide new insights into underlying causes of PSE and aid in the development of improved diagnostic and therapeutic strategies.

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