Jacobus FA Jansen, PhD

@article{RN178,
   author = {Besseling, R. M. and Jansen, J. F. and de Louw, A. J. and Vlooswijk, M. C. and Hoeberigs, M. C. and Aldenkamp, A. P. and Backes, W. H. and Hofman, P. A.},
   title = {Abnormal Profiles of Local Functional Connectivity Proximal to Focal Cortical Dysplasias},
   journal = {PLoS One},
   volume = {11},
   number = {11},
   pages = {e0166022},
   note = {Besseling, Rene M H
Jansen, Jacobus F A
de Louw, Anton J A
Vlooswijk, Marielle C G
Hoeberigs, M Christianne
Aldenkamp, Albert P
Backes, Walter H
Hofman, Paul A M
eng
2016/11/20 06:00
PLoS One. 2016 Nov 18;11(11):e0166022. doi: 10.1371/journal.pone.0166022. eCollection 2016.},
   abstract = {INTRODUCTION: Focal cortical dysplasia (FCD) is a congenital malformation of cortical development that often leads to medically refractory epilepsy. Focal resection can be an effective treatment, but is challenging as the surgically relevant abnormality may exceed the MR-visible lesion. The aim of the current study is to develop methodology to characterize the profile of functional connectivity around FCDs using resting-state functional MRI and in the individual patient. The detection of aberrant connectivity may provide a means to more completely delineate the clinically relevant lesion. MATERIALS AND METHODS: Fifteen FCD patients (age, mean+/-SD: 31+/-11 years; 11 males) and 16 matched healthy controls (35+/-9 years; 7 males) underwent structural and functional imaging at 3 Tesla. The cortical surface was reconstructed from the T1-weighted scan and the registered functional MRI data was spatially normalized to a common anatomical standard space employing the gyral pattern. Seed-based functional connectivity was determined in all subjects for all dysplasia locations. A single patient was excluded based on an aberrant FCD seed time series. Functional connectivity as a function of geodesic distance (along the cortical surface) was compared between the individual patients and the homotopic normative connectivity profiles derived from the controls. RESULTS: In 12/14 patients, aberrant profiles of functional connectivity were found, which demonstrated both hyper- and hypoconnectivity as well as combinations. Abnormal functional connectivity was typically found (also) beyond the lesion visible on structural MRI, while functional connectivity profiles not related to a lesion appeared normal in patients. CONCLUSION: This novel functional MRI technique has potential for delineating functionally aberrant from normal cortex beyond the structural lesion in FCD, which remains to be confirmed in future research.},
   keywords = {Adult
Brain/pathology
*Brain Mapping
Case-Control Studies
*Connectome
Female
Humans
Image Interpretation, Computer-Assisted
Image Processing, Computer-Assisted
*Magnetic Resonance Imaging/methods
Male
Malformations of Cortical Development/diagnostic imaging/*physiopathology
Rest
Young Adult},
   ISSN = {1932-6203 (Electronic)
1932-6203 (Linking)},
   DOI = {10.1371/journal.pone.0166022},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27861502
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115673/pdf/pone.0166022.pdf},
   year = {2016},
   type = {Journal Article}
}

@article{RN180,
   author = {Drenthen, G. S. and Barendse, E. M. and Aldenkamp, A. P. and van Veenendaal, T. M. and Puts, N. A. and Edden, R. A. and Zinger, S. and Thoonen, G. and Hendriks, M. P. and Kessels, R. P. and Jansen, J. F.},
   title = {Altered neurotransmitter metabolism in adolescents with high-functioning autism},
   journal = {Psychiatry Res Neuroimaging},
   volume = {256},
   pages = {44-49},
   note = {Drenthen, Gerhard S
Barendse, Evelien M
Aldenkamp, Albert P
van Veenendaal, Tamar M
Puts, Nicolaas A J
Edden, Richard A E
Zinger, Svitlana
Thoonen, Geert
Hendriks, Marc P H
Kessels, Roy P C
Jansen, Jacobus F A
eng
U54 HD079123/HD/NICHD NIH HHS/
R01 MH106564/MH/NIMH NIH HHS/
K99 MH107719/MH/NIMH NIH HHS/
R00 MH107719/MH/NIMH NIH HHS/
P41 EB015909/EB/NIBIB NIH HHS/
R01 EB016089/EB/NIBIB NIH HHS/
Netherlands
2016/09/30 06:00
Psychiatry Res Neuroimaging. 2016 Oct 30;256:44-49. doi: 10.1016/j.pscychresns.2016.09.007. Epub 2016 Sep 20.},
   abstract = {Previous studies have suggested that alterations in excitatory/inhibitory neurotransmitters might play a crucial role in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopy ((1)H-MRS) can provide valuable information about abnormal brain metabolism and neurotransmitter concentrations. However, few (1)H-MRS studies have been published on the imbalance of the two most abundant neurotransmitters in ASD: glutamate (Glu) and gamma-aminobutyric acid (GABA). Moreover, to our knowledge none of these published studies is performed with a study population consisting purely of high-functioning autism (HFA) adolescents. Selecting only individuals with HFA eliminates factors possibly related to intellectual impairment instead of ASD. This study aims to assess Glu and GABA neurotransmitter concentrations in HFA. Occipital concentrations of Glu and GABA plus macromolecules (GABA+) were obtained using (1)H-MRS relative to creatine (Cr) in adolescents with HFA (n=15 and n=13 respectively) and a healthy control group (n=17). Multiple linear regression revealed significantly higher Glu/Cr and lower GABA+/Glu concentrations in the HFA group compared to the controls. These results imply that imbalanced neurotransmitter levels of excitation and inhibition are associated with HFA in adolescents.},
   keywords = {Adolescent
Autism Spectrum Disorder/*metabolism
Creatine/metabolism
Female
Glutamic Acid/*metabolism
Humans
Magnetic Resonance Spectroscopy/methods
Male
Proton Magnetic Resonance Spectroscopy
gamma-Aminobutyric Acid/*metabolism
*Gamma-aminobutyric acid
*Glutamate
*Magnetic resonance spectroscopy},
   ISSN = {1872-7506 (Electronic)
0925-4927 (Linking)},
   DOI = {10.1016/j.pscychresns.2016.09.007},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27685800
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385138/pdf/nihms854039.pdf},
   year = {2016},
   type = {Journal Article}
}

@article{RN181,
   author = {Jansen, J. F. and Lu, Y. and Gupta, G. and Lee, N. Y. and Stambuk, H. E. and Mazaheri, Y. and Deasy, J. O. and Shukla-Dave, A.},
   title = {Texture analysis on parametric maps derived from dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer},
   journal = {World J Radiol},
   volume = {8},
   number = {1},
   pages = {90-7},
   note = {Jansen, Jacobus Fa
Lu, Yonggang
Gupta, Gaorav
Lee, Nancy Y
Stambuk, Hilda E
Mazaheri, Yousef
Deasy, Joseph O
Shukla-Dave, Amita
eng
R01 CA115895/CA/NCI NIH HHS/
2016/02/03 06:00
World J Radiol. 2016 Jan 28;8(1):90-7. doi: 10.4329/wjr.v8.i1.90.},
   abstract = {AIM: To investigate the merits of texture analysis on parametric maps derived from pharmacokinetic modeling with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as imaging biomarkers for the prediction of treatment response in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: In this retrospective study, 19 HNSCC patients underwent pre- and intra-treatment DCE-MRI scans at a 1.5T MRI scanner. All patients had chemo-radiation treatment. Pharmacokinetic modeling was performed on the acquired DCE-MRI images, generating maps of volume transfer rate (K(trans)) and volume fraction of the extravascular extracellular space (ve). Image texture analysis was then employed on maps of K(trans) and ve, generating two texture measures: Energy (E) and homogeneity. RESULTS: No significant changes were found for the mean and standard deviation for K(trans) and ve between pre- and intra-treatment (P > 0.09). Texture analysis revealed that the imaging biomarker E of ve was significantly higher in intra-treatment scans, relative to pretreatment scans (P < 0.04). CONCLUSION: Chemo-radiation treatment in HNSCC significantly reduces the heterogeneity of tumors.},
   keywords = {Dynamic contrast-enhanced magnetic resonance imaging
Head and neck squamous cell carcinomas
Image texture analysis
Tumor heterogeneity},
   ISSN = {1949-8470 (Print)
1949-8470 (Linking)},
   DOI = {10.4329/wjr.v8.i1.90},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/26834947
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731352/pdf/WJR-8-90.pdf},
   year = {2016},
   type = {Journal Article}
}

@article{RN182,
   author = {Jansen, J. F. and van Bussel, F. C. and van de Haar, H. J. and van Osch, M. J. and Hofman, P. A. and van Boxtel, M. P. and van Oostenbrugge, R. J. and Schram, M. T. and Stehouwer, C. D. and Wildberger, J. E. and Backes, W. H.},
   title = {Cerebral blood flow, blood supply, and cognition in Type 2 Diabetes Mellitus},
   journal = {Sci Rep},
   volume = {6},
   number = {1},
   pages = {10},
   note = {Jansen, Jacobus F A
van Bussel, Frank C G
van de Haar, Harm J
van Osch, Matthias J P
Hofman, Paul A M
van Boxtel, Martin P J
van Oostenbrugge, Robert J
Schram, Miranda T
Stehouwer, Coen D A
Wildberger, Joachim E
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
England
2016/12/07 06:00
Sci Rep. 2016 Dec 5;6(1):10. doi: 10.1038/s41598-016-0003-6.},
   abstract = {We investigated whether type 2 diabetes (T2DM) and the presence of cognitive impairment are associated with altered cerebral blood flow (CBF). Forty-one participants with and thirty-nine without T2DM underwent 3-Tesla MRI, including a quantitative technique measuring (macrovascular) blood flow in the internal carotid artery and an arterial spin labeling technique measuring (microvascular) perfusion in the grey matter (GM). Three analysis methods were used to quantify the CBF: a region of interest analysis, a voxel-based statistical parametric mapping technique, and a 'distributed deviating voxels' method. Participants with T2DM exhibited significantly more tissue with low CBF values in the cerebral cortex and the subcortical GM (3.8-fold increase). The latter was the only region where the hypoperfusion remained after correcting for atrophy, indicating that the effect of T2DM on CBF, independent of atrophy, is small. Subcortical CBF was associated with depression. No associations were observed for CBF in other regions with diabetes status, for carotid blood flow with diabetes status, or for CBF or flow in relation with cognitive function. To conclude, a novel method that tallies total 'distributed deviating voxels' demonstrates T2DM-associated hypoperfusion in the subcortical GM, not associated with cognitive performance. Whether a vascular mechanism underlies cognitive decrements remains inconclusive.},
   keywords = {Aged
Anthropometry
*Cerebrovascular Circulation
*Cognition
Diabetes Mellitus, Type 2/*pathology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged},
   ISSN = {2045-2322 (Electronic)
2045-2322 (Linking)},
   DOI = {10.1038/s41598-016-0003-6},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27920431
https://www.nature.com/articles/s41598-016-0003-6.pdf},
   year = {2016},
   type = {Journal Article}
}

@article{RN183,
   author = {Jansen, J. F. A. and Parra, C. and Lu, Y. and Shukla-Dave, A.},
   title = {Evaluation of Head and Neck Tumors with Functional MR Imaging},
   journal = {Magn Reson Imaging Clin N Am},
   volume = {24},
   number = {1},
   pages = {123-133},
   note = {Jansen, Jacobus F A
Parra, Carlos
Lu, Yonggang
Shukla-Dave, Amita
eng
R21 CA176660/CA/NCI NIH HHS/
1 R21CA176660-01A1/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
Review
2015/11/29 06:00
Magn Reson Imaging Clin N Am. 2016 Feb;24(1):123-133. doi: 10.1016/j.mric.2015.08.011.},
   abstract = {Head and neck cancer is one of the most common cancers worldwide. MR imaging-based diffusion and perfusion techniques enable the noninvasive assessment of tumor biology and physiology, which supplement information obtained from standard structural scans. Diffusion and perfusion MR imaging techniques provide novel biomarkers that can aid monitoring in pretreatment, during treatment, and posttreatment stages to improve patient selection for therapeutic strategies; provide evidence for change of therapy regime; and evaluate treatment response. This review discusses pertinent aspects of the role of diffusion and perfusion MR imaging and computational analysis methods in studying head and neck cancer.},
   keywords = {Diffusion Magnetic Resonance Imaging/*trends
Head and Neck Neoplasms/complications/*diagnosis
Humans
Magnetic Resonance Angiography/*trends
Multimodal Imaging/trends
Neovascularization, Pathologic/complications/*diagnosis
Data processing
Diffusion
Head and neck cancer
MR imaging
Perfusion},
   ISSN = {1557-9786 (Electronic)
1064-9689 (Linking)},
   DOI = {10.1016/j.mric.2015.08.011},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/26613878
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663682/pdf/nihms717990.pdf},
   year = {2016},
   type = {Journal Article}
}

@article{RN179,
   author = {M., IJff D. and van Veenendaal, T. M. and Debeij-van Hall, M. H. and Jansen, J. F. and de Louw, A. J. and Majoie, M. H. and Aldenkamp, A. P.},
   title = {The Cognitive Profile of Ethosuximide in Children},
   journal = {Paediatr Drugs},
   volume = {18},
   number = {5},
   pages = {379-85},
   note = {IJff, Dominique M
van Veenendaal, Tamar M
Debeij-van Hall, Mariette H
Jansen, Jacobus F A
de Louw, Anton J A
Majoie, Marian H J M
Aldenkamp, Albert P
eng
Switzerland
2016/08/26 06:00
Paediatr Drugs. 2016 Oct;18(5):379-85. doi: 10.1007/s40272-016-0187-z.},
   abstract = {INTRODUCTION: Although ethosuximide is one of the oldest antiepileptic drugs (AEDs), little information is available about the cognitive side effects of ethosuximide. OBJECTIVE: The aim of this study was to investigate the cognitive profile of ethosuximide. METHODS: In this cross-sectional study, we used an extensive neuropsychological test battery in patients with epilepsy aged 6-16 years who were treated with monotherapy ethosuximide. We evaluated the efficacy of the drug by seizure frequency (seizure free or not). RESULTS: We included 61 patients with a mean age of 9.4 years [standard deviation (SD) 2.7] who used on average 686 mg/day (SD 245) ESM as monotherapy. ESM was effective in the majority of the patients (70 % were seizure free for at least 6 months at moment of inclusion). The total study population showed impairments of intelligence, visuomotor, and attentional function including activation/alertness. Comparisons between the well-controlled patients and patients who were not in remission showed significantly lower intelligence values and lower performance on the visual-perceptual and attentional tasks for the group with ongoing seizures. Our results suggested that the higher order cognitive dysfunctions (such as intelligence and visual-perceptual functions) may be regarded as seizure or aetiology effects and that the impaired fluid cognitive functions, such as activation/alertness, sustained auditory attention and attentional control or switching, were due to ESM. CONCLUSION: This study suggests the attentional dysfunction resulting in psychomotor slowing and alertness deficits may be regarded as effects of ethosuximide. Although no untreated baseline assessment was available, these effects are comparable to those of other AEDs, and ethosuximide may therefore be considered an AED with only mild effects on cognition. As ethosuximide is a first-line therapy for absence seizures in childhood, and drug-induced cognitive impairment may interfere with development, learning, and academic achievement, these findings are of interest to clinicians who prescribe this drug, especially when informing parents.},
   keywords = {Adolescent
Anticonvulsants/*therapeutic use
Child
Cognition/drug effects
Cross-Sectional Studies
Epilepsy, Absence/*drug therapy
Ethosuximide/*therapeutic use
Female
Humans
Male
Retrospective Studies
Seizures/drug therapy},
   ISSN = {1179-2019 (Electronic)
1174-5878 (Linking)},
   DOI = {10.1007/s40272-016-0187-z},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27557905
https://link.springer.com/article/10.1007%2Fs40272-016-0187-z},
   year = {2016},
   type = {Journal Article}
}

@article{RN184,
   author = {van Bussel, F. C. and Backes, W. H. and Hofman, P. A. and Puts, N. A. and Edden, R. A. and van Boxtel, M. P. and Schram, M. T. and Stehouwer, C. D. and Wildberger, J. E. and Jansen, J. F.},
   title = {Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning},
   journal = {Medicine (Baltimore)},
   volume = {95},
   number = {36},
   pages = {e4803},
   note = {van Bussel, Frank C G
Backes, Walter H
Hofman, Paul A M
Puts, Nicolaas A J
Edden, Richard A E
van Boxtel, Martin P J
Schram, Miranda T
Stehouwer, Coen D A
Wildberger, Joachim E
Jansen, Jacobus F A
eng
P41 EB015909/EB/NIBIB NIH HHS/
R01 EB016089/EB/NIBIB NIH HHS/
2016/09/08 06:00
Medicine (Baltimore). 2016 Sep;95(36):e4803. doi: 10.1097/MD.0000000000004803.},
   abstract = {Type 2 diabetes mellitus is associated with accelerated cognitive decline. The underlying pathophysiological mechanisms still remain to be elucidated although it is known that insulin signaling modulates neurotransmitter activity, including inhibitory gamma-aminobutyric acid (GABA) and excitatory glutamate (Glu) receptors. Therefore, we examined whether levels of GABA and Glu are related to diabetes status and cognitive performance.Forty-one participants with type 2 diabetes and 39 participants without type 2 diabetes underwent detailed cognitive assessments and 3-Tesla proton MR spectroscopy. The associations of neurotransmitters with type 2 diabetes and cognitive performance were examined using multivariate regression analyses controlling for age, sex, education, BMI, and percentage gray/white matter ratio in spectroscopic voxel.Analysis revealed higher GABA+ levels in participants with type 2 diabetes, in participants with higher fasting blood glucose levels and in participants with higher HbA1c levels, and higher GABA+ levels in participants with both high HbA1c levels and less cognitive performance.To conclude, participants with type 2 diabetes have alterations in the GABAergic neurotransmitter system, which are related to lower cognitive functioning, and hint at the involvement of an underlying metabolic mechanism.},
   keywords = {Aged
Blood Glucose/metabolism
Case-Control Studies
*Cognition
Cognitive Dysfunction/etiology/*metabolism
Diabetes Mellitus, Type 2/*physiopathology/*psychology
Female
Glutamic Acid/metabolism
Glycated Hemoglobin A/metabolism
Gray Matter/diagnostic imaging/metabolism
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Middle Aged
Neuropsychological Tests
White Matter/diagnostic imaging/metabolism
gamma-Aminobutyric Acid/*metabolism},
   ISSN = {1536-5964 (Electronic)
0025-7974 (Linking)},
   DOI = {10.1097/MD.0000000000004803},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27603392
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023915/pdf/medi-95-e4803.pdf},
   year = {2016},
   type = {Journal Article}
}

@article{RN185,
   author = {van Bussel, F. C. and Backes, W. H. and Hofman, P. A. and van Boxtel, M. P. and Schram, M. T. and Stehouwer, C. D. and Wildberger, J. E. and Jansen, J. F.},
   title = {Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements},
   journal = {J Neuroendocrinol},
   volume = {28},
   number = {3},
   pages = {12366},
   note = {van Bussel, F C G
Backes, W H
Hofman, P A M
van Boxtel, M P J
Schram, M T
Stehouwer, C D A
Wildberger, J E
Jansen, J F A
eng
Research Support, Non-U.S. Gov't
2016/01/23 06:00
J Neuroendocrinol. 2016 Mar;28(3):12366. doi: 10.1111/jne.12366.},
   abstract = {Type 2 diabetes mellitus is associated with cognitive decrements. Specifically affected cognitive domains are learning and memory, for which the hippocampus plays an essential role. The pathophysiological mechanism remains to be revealed. The present study examined whether local hippocampal microstructure and white matter connectivity are related to type 2 diabetes and memory performance. Forty participants with type 2 diabetes and 38 participants without type 2 diabetes underwent detailed cognitive assessment and 3-Tesla diffusion magnetic resonance imaging (MRI). Diffusion MRI was performed to assess microstructure (fractional anisotropy and mean diffusivity) and white matter connectivity (tract volume) of the hippocampus, which were compared between participants with and without type 2 diabetes. No differences in hippocampal microstructure were observed. Participants with type 2 diabetes had fewer white matter connections between the hippocampus and frontal lobe (P = 0.017). Participants who scored lower on memory function, regardless of type 2 diabetes, had fewer white matter connections between the hippocampus and temporal lobe (P = 0.017). Taken together, type 2 diabetes and memory decrements appear to be associated with altered hippocampal white matter connectivity.},
   keywords = {Aged
Case-Control Studies
Cognition Disorders/*etiology/pathology
Diabetes Mellitus, Type 2/*complications/*pathology/psychology
Diffusion Tensor Imaging
Female
Hippocampus/*pathology
Humans
Magnetic Resonance Imaging
Male
Memory/physiology
Middle Aged
Nerve Net/*pathology
White Matter/*pathology
cognition
diffusion
hippocampus
memory
white matter connectivity},
   ISSN = {1365-2826 (Electronic)
0953-8194 (Linking)},
   DOI = {10.1111/jne.12366},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/26791354
https://onlinelibrary.wiley.com/doi/abs/10.1111/jne.12366},
   year = {2016},
   type = {Journal Article}
}

@article{RN186,
   author = {van Bussel, F. C. and Backes, W. H. and van Veenendaal, T. M. and Hofman, P. A. and van Boxtel, M. P. and Schram, M. T. and Sep, S. J. and Dagnelie, P. C. and Schaper, N. and Stehouwer, C. D. and Wildberger, J. E. and Jansen, J. F.},
   title = {Functional Brain Networks Are Altered in Type 2 Diabetes and Prediabetes: Signs for Compensation of Cognitive Decrements? The Maastricht Study},
   journal = {Diabetes},
   volume = {65},
   number = {8},
   pages = {2404-13},
   note = {van Bussel, Frank C G
Backes, Walter H
van Veenendaal, Tamar M
Hofman, Paul A M
van Boxtel, Martin P J
Schram, Miranda T
Sep, Simone J S
Dagnelie, Pieter C
Schaper, Nicolaas
Stehouwer, Coen D A
Wildberger, Joachim E
Jansen, Jacobus F A
eng
Research Support, Non-U.S. Gov't
2016/05/25 06:00
Diabetes. 2016 Aug;65(8):2404-13. doi: 10.2337/db16-0128. Epub 2016 May 23.},
   abstract = {Type 2 diabetes is associated with cognitive decrements, accelerated cognitive decline, and increased risk for dementia. Patients with the metabolic syndrome, a major risk factor for diabetes, may display comparable cognitive decrements as seen in type 2 diabetes. Currently, the impact of diabetes and prediabetes on cognition and the underlying organization of functional brain networks still remain to be elucidated. This study investigated whether functional brain networks are affected in type 2 diabetes and prediabetes. Forty-seven participants with diabetes, 47 participants with prediabetes, and 45 control participants underwent detailed cognitive testing and 3-Tesla resting state functional MRI. Graph theoretical network analysis was performed to investigate alterations in functional cerebral networks. Participants with diabetes displayed altered network measures, characterized by a higher normalized cluster coefficient and higher local efficiency, compared with control participants. The network measures of the participants with prediabetes fell between those with diabetes and control participants. Lower processing speed was associated with shorter path length and higher global efficiency. Participants with type 2 diabetes have altered functional brain networks. This alteration is already apparent in the prediabetic stage to a somewhat lower level, hinting at functional reorganization of the cerebral networks as a compensatory mechanism for cognitive decrements.},
   keywords = {Aged
Brain/metabolism/physiopathology
Brain Mapping
Cognition/physiology
Cognition Disorders/metabolism/physiopathology
Cross-Sectional Studies
Diabetes Mellitus, Type 2/*metabolism/*physiopathology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Prediabetic State/*metabolism/*physiopathology},
   ISSN = {1939-327X (Electronic)
0012-1797 (Linking)},
   DOI = {10.2337/db16-0128},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27217484
https://diabetes.diabetesjournals.org/content/diabetes/65/8/2404.full.pdf},
   year = {2016},
   type = {Journal Article}
}

@article{RN187,
   author = {van de Haar, H. J. and Burgmans, S. and Jansen, J. F. and van Osch, M. J. and van Buchem, M. A. and Muller, M. and Hofman, P. A. and Verhey, F. R. and Backes, W. H.},
   title = {Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease},
   journal = {Radiology},
   volume = {281},
   number = {2},
   pages = {527-535},
   note = {van de Haar, Harm J
Burgmans, Saartje
Jansen, Jacobus F A
van Osch, Matthias J P
van Buchem, Mark A
Muller, Majon
Hofman, Paul A M
Verhey, Frans R J
Backes, Walter H
eng
2016/10/19 06:00
Radiology. 2016 Nov;281(2):527-535. doi: 10.1148/radiol.2016152244. Epub 2016 May 31.},
   abstract = {Purpose To investigate whether the blood-brain barrier (BBB) leaks blood-circulating substances in patients with early forms of Alzheimer disease (AD), and if so, to examine the extent and pattern of leakage. Materials and Methods This study was approved by the local medical ethical committees of the Maastricht University Medical Center and Leiden University Medical Center, and written informed consent was obtained from all subjects. For this pilot study, 16 patients with early AD and 17 healthy age-matched control subjects underwent dynamic contrast material-enhanced magnetic resonance (MR) imaging sequence with dual time resolution for 25 minutes. The Patlak graphical approach was used to quantify the BBB leakage rate and local blood plasma volume. Subsequent histogram analysis was used to determine the volume fraction of the leaking brain tissue. Differences were assessed with linear regression analysis, adjusted for confounding variables. Results The BBB leakage rate was significantly higher in patients compared with that in control subjects in the total gray matter (P < .05) and cortex (P = .03). Patients had a significantly higher volume fraction of the leaking brain tissue in the gray matter (P = .004), normal-appearing white matter (P < .04), deep gray matter (P = .01), and cortex (P = .004). When all subjects were considered, scores on the Mini-Mental State Examination decreased significantly with increasing leakage in the deep gray matter (P = .007) and cortex (P < .05). Conclusion The results of this study showed global BBB leakage in patients with early AD that is associated with cognitive decline. A compromised BBB may be part of a cascade of pathologic events that eventually lead to cognitive decline and dementia. ((c))RSNA, 2016 Online supplemental material is available for this article.},
   keywords = {Aged
Aged, 80 and over
Alzheimer Disease/*diagnostic imaging/*pathology
Blood Volume
Blood-Brain Barrier/*diagnostic imaging/*pathology
Case-Control Studies
Contrast Media
Female
Humans
Magnetic Resonance Imaging/*methods
Male
Middle Aged
Pilot Projects},
   ISSN = {1527-1315 (Electronic)
0033-8419 (Linking)},
   DOI = {10.1148/radiol.2016152244},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27243267},
   year = {2016},
   type = {Journal Article}
}

@article{RN188,
   author = {van de Haar, H. J. and Jansen, J. F. A. and van Osch, M. J. P. and van Buchem, M. A. and Muller, M. and Wong, S. M. and Hofman, P. A. M. and Burgmans, S. and Verhey, F. R. J. and Backes, W. H.},
   title = {Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging},
   journal = {Neurobiol Aging},
   volume = {45},
   pages = {190-196},
   note = {van de Haar, Harm J
Jansen, Jacobus F A
van Osch, Matthias J P
van Buchem, Mark A
Muller, Majon
Wong, Sau May
Hofman, Paul A M
Burgmans, Saartje
Verhey, Frans R J
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2016/07/28 06:00
Neurobiol Aging. 2016 Sep;45:190-196. doi: 10.1016/j.neurobiolaging.2016.06.006. Epub 2016 Jun 17.},
   abstract = {The neurovascular unit, which protects neuronal cells and supplies them with essential molecules, plays an important role in the pathophysiology of Alzheimer's Disease (AD). The aim of this study was to noninvasively investigate 2 linked functional elements of the neurovascular unit, blood-brain barrier (BBB) permeability and cerebral blood flow (CBF), in patients with early AD and healthy controls. Therefore, both dynamic contrast-enhanced magnetic resonance imaging and arterial spin labeling magnetic resonance imaging were applied to measure BBB permeability and CBF, respectively. The patients with early AD showed significantly lower CBF and local blood volume in the gray matter, compared with controls. In the patients, we also found that a reduction in CBF is correlated with an increase in leakage rate. This finding supports the hypothesis that neurovascular damage, and in particular impairment of the neurovascular unit constitutes the pathophysiological link between CBF reduction and BBB impairment in AD.},
   keywords = {Aged
Aged, 80 and over
Alzheimer Disease/*diagnostic imaging/*etiology/pathology
Blood-Brain Barrier/diagnostic imaging/pathology/physiopathology
Cerebrovascular Circulation/physiology
Female
Gray Matter/blood supply/diagnostic imaging
Humans
Magnetic Resonance Imaging/*methods
Male
Microvessels/diagnostic imaging/pathology/physiopathology
*Alzheimer's disease
*Blood-brain barrier
*Cerebral hemodynamics
*Dementia
*Magnetic resonance imaging},
   ISSN = {1558-1497 (Electronic)
0197-4580 (Linking)},
   DOI = {10.1016/j.neurobiolaging.2016.06.006},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27459939
https://www.sciencedirect.com/science/article/abs/pii/S0197458016301063?via%3Dihub},
   year = {2016},
   type = {Journal Article}
}

@article{RN189,
   author = {van de Weijer, S. C. and Duits, A. A. and Bloem, B. R. and Kessels, R. P. and Jansen, J. F. and Kohler, S. and Tissingh, G. and Kuijf, M. L.},
   title = {The Parkin'Play study: protocol of a phase II randomized controlled trial to assess the effects of a health game on cognition in Parkinson's disease},
   journal = {BMC Neurol},
   volume = {16},
   number = {1},
   pages = {209},
   note = {van de Weijer, Sjors C F
Duits, Annelien A
Bloem, Bastiaan R
Kessels, Roy P
Jansen, Jacobus F A
Kohler, Sebastian
Tissingh, Gerrit
Kuijf, Mark L
eng
Clinical Trial, Phase II
Multicenter Study
Randomized Controlled Trial
England
2016/11/05 06:00
BMC Neurol. 2016 Nov 3;16(1):209. doi: 10.1186/s12883-016-0731-z.},
   abstract = {BACKGROUND: In Parkinson's disease (PD), cognitive impairment is an important non-motor symptom heralding the development of dementia. Effective treatments to slow down the rate of cognitive decline in PD patients with mild cognitive impairment are lacking. Here, we describe the design of the Parkin'Play study, which assesses the effects of a cognitive health game intervention on cognition in PD. METHODS/DESIGN: This study is a multicentre, phase-II, open-randomized clinical trial that aims to recruit 222 PD patients with mild cognitive impairment. Eligible patients have PD, Hoehn & Yahr stages I-III, are aged between 40 and 75 years, and have cognitive impairment but no dementia. The intervention group (n = 111) will be trained using a web-based health game targeting multiple cognitive domains. The control group (n = 111) will be placed on a waiting list. In order to increase compliance the health game adapts to the subjects' performance, is enjoyable, and can be played at home. From each group, 20 patients will undergo fMRI to test for potential functional brain changes underlying treatment. The primary outcome after 12 weeks of training is cognitive function, as assessed by a standard neuropsychological assessment battery and an online cognitive assessment. The neuropsychological assessment battery covers the following domains: executive function, memory, visual perception, visuoconstruction and language. A compound score for overall cognitive function will be calculated as the mean score of all test Z-scores based on the distribution of scores for both groups taken together. Secondary outcomes at follow-up visits up to 24 weeks include various motor and non-motor symptoms, compliance, and biological endpoints (fMRI). DISCUSSION: This study aims at evaluating whether a cognitive intervention among PD patients leads to an increased cognitive performance on targeted domains. Strengths of this study are a unique web-based health game intervention, the large sample size, a control group without intervention and innovations designed to increase compliance. TRIAL REGISTRATION: NTR5637 on 7-jan-2016.},
   keywords = {Adult
Aged
Cognitive Dysfunction/etiology/psychology/*therapy
Executive Function
Humans
Language
Memory
Middle Aged
Neuropsychological Tests
Parkinson Disease/complications/*psychology
Treatment Outcome
*Video Games
Visual Perception
Cognitive functions
Health game
Mild cognitive impairment
Parkinson disease
Rct},
   ISSN = {1471-2377 (Electronic)
1471-2377 (Linking)},
   DOI = {10.1186/s12883-016-0731-z},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27809791
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093943/pdf/12883_2016_Article_731.pdf},
   year = {2016},
   type = {Journal Article}
}

@article{RN190,
   author = {van der Kruijs, S. J. and Vonck, K. E. and Langereis, G. R. and Feijs, L. M. and Bodde, N. M. and Lazeron, R. H. and Carrette, E. and Boon, P. A. and Backes, W. H. and Jansen, J. F. and Aldenkamp, A. P. and Cluitmans, P. J.},
   title = {Autonomic nervous system functioning associated with psychogenic nonepileptic seizures: Analysis of heart rate variability},
   journal = {Epilepsy Behav},
   volume = {54},
   pages = {14-9},
   note = {van der Kruijs, Sylvie J M
Vonck, Kristl E J
Langereis, Geert R
Feijs, Loe M G
Bodde, Nynke M G
Lazeron, Richard H C
Carrette, Evelien
Boon, Paul A J M
Backes, Walter H
Jansen, Jacobus F A
Aldenkamp, Albert P
Cluitmans, Pierre J M
eng
2015/11/30 06:00
Epilepsy Behav. 2016 Jan;54:14-9. doi: 10.1016/j.yebeh.2015.10.014. Epub 2015 Nov 25.},
   abstract = {OBJECTIVE: Psychogenic nonepileptic seizures (PNESs) resemble epileptic seizures but originate from psychogenic rather than organic causes. Patients with PNESs are often unable or unwilling to reflect on underlying emotions. To gain more insight into the internal states of patients during PNES episodes, this study explored the time course of heart rate variability (HRV) measures, which provide information about autonomic nervous system functioning and arousal. METHODS: Heart rate variability measures were extracted from double-lead electrocardiography data collected during 1-7days of video-electroencephalography monitoring of 20 patients with PNESs, in whom a total number of 118 PNESs was recorded. Heart rate (HR) and HRV measures in time and frequency domains (standard deviation of average beat-to-beat intervals (SDANN), root mean square of successive differences (RMSSD), high-frequency (HF) power, low-frequency (LF) power, and very low-frequency (VLF) power) were averaged over consecutive five-minute intervals. Additionally, quantitative analyses of Poincare plot parameters (SD1, SD2, and SD1/SD2 ratio) were performed. RESULTS: In the five-minute interval before PNES, HR significantly (p<0.05) increased (d=2.5), whereas SDANN (d=-0.03) and VLF power (d=-0.05) significantly decreased. During PNES, significant increases in HF power (d=0.0006), SD1 (d=0.031), and SD2 (d=0.016) were observed. In the five-minute interval immediately following PNES, SDANN (d=0.046) and VLF power (d=0.073) significantly increased, and HR (d=-5.1) and SD1/SD2 ratio (d=-0.14) decreased, compared to the interval preceding PNES. CONCLUSION: The results suggest that PNES episodes are preceded by increased sympathetic functioning, which is followed by an increase in parasympathetic functioning during and after PNES. Future research needs to identify the exact nature of the increased arousal that precedes PNES.},
   keywords = {Adult
Arousal/physiology
Autonomic Nervous System/*physiopathology
Electrocardiography
Emotions/physiology
Female
Heart Rate/*physiology
Humans
Male
Middle Aged
Psychophysiologic Disorders/*physiopathology/psychology
Seizures/*physiopathology/psychology
Young Adult
Autonomic nervous system
Conversion disorder
Heart rate variability
Psychogenic nonepileptic seizures
Vagal tone},
   ISSN = {1525-5069 (Electronic)
1525-5050 (Linking)},
   DOI = {10.1016/j.yebeh.2015.10.014},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/26615481
https://www.epilepsybehavior.com/article/S1525-5050(15)00574-0/fulltext
https://www.epilepsybehavior.com/article/S1525-5050(15)00574-0/pdf},
   year = {2016},
   type = {Journal Article}
}

@article{RN191,
   author = {van Veenendaal, T. M. and M., IJff D. and Aldenkamp, A. P. and Lazeron, R. H. C. and Puts, N. A. J. and Edden, R. A. E. and Hofman, P. A. M. and de Louw, A. J. A. and Backes, W. H. and Jansen, J. F. A.},
   title = {Glutamate concentrations vary with antiepileptic drug use and mental slowing},
   journal = {Epilepsy Behav},
   volume = {64},
   number = {Pt A},
   pages = {200-205},
   note = {van Veenendaal, Tamar M
IJff, Dominique M
Aldenkamp, Albert P
Lazeron, Richard H C
Puts, Nicolaas A J
Edden, Richard A E
Hofman, Paul A M
de Louw, Anton J A
Backes, Walter H
Jansen, Jacobus F A
eng
2016/10/17 06:00
Epilepsy Behav. 2016 Nov;64(Pt A):200-205. doi: 10.1016/j.yebeh.2016.08.027. Epub 2016 Oct 13.},
   abstract = {OBJECTIVE: Although antiepileptic drugs (AEDs) are effective in suppressing epileptic seizures, they also induce (cognitive) side effects, with mental slowing as a general effect. This study aimed to assess whether concentrations of MR detectable neurotransmitters, glutamate and GABA, are associated with mental slowing in patients with epilepsy taking AEDs. METHODS: Cross-sectional data were collected from patients with localization-related epilepsy using a variety of AEDs from three risk categories, i.e., AEDs with low, intermediate, and high risks of developing cognitive problems. Patients underwent 3T MR spectroscopy, including a PRESS (n=55) and MEGA-PRESS (n=43) sequence, to estimate occipital glutamate and GABA concentrations, respectively. The association was calculated between neurotransmitter concentrations and central information processing speed, which was measured using the Computerized Visual Searching Task (CVST) and compared between the different risk categories. RESULTS: Combining all groups, patients with lower processing speeds had lower glutamate concentrations. Patients in the high-risk category had a lower glutamate concentration and lower processing speed compared with patients taking low-risk AEDs. Patients taking intermediate-risk AEDs also had a lower glutamate concentration compared with patients taking low-risk AEDs, but processing speed did not differ significantly between those groups. No associations were found between the GABA concentration and risk category or processing speed. CONCLUSIONS: For the first time, a relation is shown between glutamate concentration and both mental slowing and AED use. It is suggested that the reduced excitatory action, reflected by lowered glutamate concentrations, may have contributed to the slowing of information processing in patients using AEDs with higher risks of cognitive side effects.},
   keywords = {Adult
Anticonvulsants/*therapeutic use
Cognition/*physiology
Cross-Sectional Studies
Epilepsy/diagnostic imaging/drug therapy/*metabolism/psychology
Female
Glutamic Acid/*metabolism
Humans
Magnetic Resonance Spectroscopy
Male
Middle Aged
Neuropsychological Tests
Occipital Lobe/diagnostic imaging/*metabolism
gamma-Aminobutyric Acid/metabolism
*Anticonvulsant
*Cognitive side effects
*Gaba
*Glutamate
*MR spectroscopy},
   ISSN = {1525-5069 (Electronic)
1525-5050 (Linking)},
   DOI = {10.1016/j.yebeh.2016.08.027},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27744245
https://www.epilepsybehavior.com/article/S1525-5050(16)30430-9/fulltext
https://www.epilepsybehavior.com/article/S1525-5050(16)30430-9/pdf},
   year = {2016},
   type = {Journal Article}
}

@article{RN173,
   author = {Braakman, H. M. and Vaessen, M. J. and Jansen, J. F. and Debeij-van Hall, M. H. and de Louw, A. and Hofman, P. A. and Vles, J. S. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Aetiology of cognitive impairment in children with frontal lobe epilepsy},
   journal = {Acta Neurol Scand},
   volume = {131},
   number = {1},
   pages = {17-29},
   note = {Braakman, H M H
Vaessen, M J
Jansen, J F A
Debeij-van Hall, M H J A
de Louw, A
Hofman, P A M
Vles, J S H
Aldenkamp, A P
Backes, W H
eng
Research Support, Non-U.S. Gov't
Denmark
2014/09/12 06:00
Acta Neurol Scand. 2015 Jan;131(1):17-29. doi: 10.1111/ane.12283. Epub 2014 Sep 10.},
   abstract = {OBJECTIVES: Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE), but its aetiology is unknown. MRI scans often reveal no structural brain abnormalities that could explain the cognitive impairment. This does not exclude more subtle morphological abnormalities that can only be detected by automated morphometric techniques. AIMS: With these techniques, we investigate the relationship between cortical brain morphology and cognitive functioning in a cohort of children with FLE and healthy controls. MATERIALS AND METHODS: Thirty-four children aged 8-13 years with FLE of unknown cause and 41 healthy age-matched controls underwent neuropsychological assessment and structural brain MRI. Patients were grouped as cognitively impaired or unimpaired. Intracranial volume, white matter volume, lobular cortical volume, cortical thickness and volumes of cortex structures were compared between patients and controls, and potential correlations with cognitive status were determined. RESULTS: The group of cognitively impaired children with FLE had significantly smaller left temporal cortex volumes, specifically middle temporal grey matter volume and entorhinal cortex thickness. In addition, cognitively impaired children with FLE had smaller volumes of structures in the left and right frontal cortex, right temporal cortex and the left subcortical area. CONCLUSION: Cognitively impaired children with FLE have smaller volumes of various cortex structures within the frontal lobes and in extra-frontal regions, most notably temporal cortex volumes. These findings might well explain the broad scale of cognitive domains affected in children with FLE complicated by cognitive impairment and highlight that FLE impacts on areas beyond the frontal lobe.},
   keywords = {Adolescent
Brain/*pathology
Child
Cognition Disorders/*etiology/*pathology
Epilepsy, Frontal Lobe/*complications/*pathology
Female
Humans
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Mri
all epilepsy/seizures
all paediatric
neuropsychological assessment
volumetric MRI},
   ISSN = {1600-0404 (Electronic)
0001-6314 (Linking)},
   DOI = {10.1111/ane.12283},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/25208759
https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.12283},
   year = {2015},
   type = {Journal Article}
}

@article{RN237,
   author = {Jansen, J. F. and Vlooswijk, M. C. and Reijs, R. P. and Majoie, H. J. and Hofman, P. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Multimodal MRI Reveals Secondarily Generalized Seizure Related Abnormalities at 1.5 T: Preliminary Findings},
   journal = {JMED Research},
   volume = {2015},
   pages = {397761},
   abstract = {Patients with chronic epilepsy, who have suffered a high number of secondarily generalized tonicclonic seizures (SGTCS) frequently show cognitive comorbidity. It is yet unclear whether a higher
number of SGTCS is associated with tissue changes in the brain. We have investigated in patients with chronic epilepsy whether a high number of SGTCS accumulated over life is associated with
microstructural changes in brain tissue. Sixteen patients with localization-related epilepsy with SGTCS underwent a multimodal quantitative Magnetic Resonance (MR) examination at 1.5 T,
comprising T2 relaxometry, and diffusion weighted imaging to study microstructural changes in the temporal and frontal lobes. Fourteen healthy volunteers were also included to assess the
effect of age. Patients with more than 20 SGTCS (n=8) showed a significantly lower IQ (-20%, p<0.05) compared to those with less than 20 SGTCS (n=8). Furthermore, regional combined
multimodal analysis revealed that significant quantitative MRI changes, related to the number of SGTCS, were present in the frontal lobe but not in the temporal lobe. Moreover, the left and right
frontal lobe generally displayed lower T2 relaxation times, smaller pericortical cerebrospinal fluid fraction and lower apparent diffusion coefficients, in the patients with more than 20 SGTCS.
These findings suggest that SGTCS are associated with substantial changes in microstructural brain tissue characteristics within the frontal lobes. These frontal changes possibly explain the
cognitive problems which are often observed in patients with many SGTCS. This knowledge may help in the development of treatment aimed at preventing decline in cognitive abilities.},
   keywords = {Epilepsy
Secondarily generalized tonic-clonic seizures
Quantitative MRI
Cognitive decline},
   ISSN = {2333-2395},
   DOI = {10.5171/2015.397761},
   url = {https://ibimapublishing.com/articles/JMED/2015/397761/},
   year = {2015},
   type = {Journal Article}
}

@article{RN174,
   author = {M., IJff D. and van Veenendaal, T. M. and Majoie, H. J. and de Louw, A. J. and Jansen, J. F. and Aldenkamp, A. P.},
   title = {Cognitive effects of lacosamide as adjunctive therapy in refractory epilepsy},
   journal = {Acta Neurol Scand},
   volume = {131},
   number = {6},
   pages = {347-54},
   note = {IJff, D M
van Veenendaal, T M
Majoie, H J M
de Louw, A J A
Jansen, J F A
Aldenkamp, A P
eng
Clinical Trial
Denmark
2015/01/30 06:00
Acta Neurol Scand. 2015 Jun;131(6):347-54. doi: 10.1111/ane.12372. Epub 2015 Jan 28.},
   abstract = {BACKGROUND: Lacosamide (LCM) is a novel antiepileptic drug (AED) with potential benefit as adjunctive treatment in patients with partial-onset seizures. As yet, limited information on cognitive effects of LCM is available, especially in real-life settings. AIMS: In this open clinical prospective study, the cognitive effects of LCM were evaluated when used as adjunctive antiepileptic therapy in patients with refractory epilepsy. METHODS: We included 33 patients aged between 16 and 74 years (mean: 37 years). All patients had a localization-related epilepsy. Patients were assessed at baseline before starting LCM treatment and during follow-up when the optimal clinical dose was achieved. MATERIALS: Subjective complaints were evaluated using the SIDAED; effects on cognition were evaluated using the computerized visual searching task (CVST). RESULTS: The CVST showed significant faster information processing reaction times at the second evaluation (P = 0.013), which was not correlated with seizure control, type of epilepsy, age, gender, drug load, number of concomitant drugs, dose or duration of LCM treatment. On the SIDAED, patients complained more about their cognitive function at the second evaluation (P = 0.005). For the SIDAED, a positive correlation at follow-up was found between the total severity score and higher age (r = 0.375, P = 0.031), but not with epilepsy factors or treatment characteristics. DISCUSSION/CONLUSION: Screening of the cognitive effects of LCM showed that LCM does not have negative effects on information processing speed. As this is the most sensitive function for cognitive side effects of AEDs, LCM does not seem to induce the common negative cognitive effects. Remarkably, patients complained more, especially about their cognitive function, which is possible the 'doing better, feeling worse phenomenon'.},
   keywords = {Acetamides/*adverse effects/therapeutic use
Adolescent
Adult
Aged
Anticonvulsants/*adverse effects/therapeutic use
Cognition/*drug effects
Epilepsy/*drug therapy
Female
Humans
Lacosamide
Male
Middle Aged
Prospective Studies
Treatment Outcome
adverse effects
anti-epileptic drug
cognition
epilepsy},
   ISSN = {1600-0404 (Electronic)
0001-6314 (Linking)},
   DOI = {10.1111/ane.12372},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/25630655
https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.12372},
   year = {2015},
   type = {Journal Article}
}

@article{RN175,
   author = {van Bussel, F. C. and Backes, W. H. and Hofman, P. A. and van Oostenbrugge, R. J. and Kessels, A. G. and van Boxtel, M. P. and Schram, M. T. and Stehouwer, C. D. and Wildberger, J. E. and Jansen, J. F.},
   title = {On the interplay of microvasculature, parenchyma, and memory in type 2 diabetes},
   journal = {Diabetes Care},
   volume = {38},
   number = {5},
   pages = {876-82},
   note = {van Bussel, Frank C
Backes, Walter H
Hofman, Paul A
van Oostenbrugge, Robert J
Kessels, Alfons G
van Boxtel, Martin P
Schram, Miranda T
Stehouwer, Coen D
Wildberger, Joachim E
Jansen, Jacobus F
eng
Observational Study
Research Support, Non-U.S. Gov't
2015/02/19 06:00
Diabetes Care. 2015 May;38(5):876-82. doi: 10.2337/dc14-2043. Epub 2015 Feb 17.},
   abstract = {OBJECTIVE: Type 2 diabetes is associated with accelerated cognitive decline, especially regarding memory for which the hippocampus plays an essential role. The pathophysiological mechanisms still remain to be elucidated. The purpose of this study is to examine whether hippocampal microvascular and microstructural changes are related to type 2 diabetes (based on status or based on fasting blood glucose [FBG] levels) and verbal memory performance. RESEARCH DESIGN AND METHODS: Thirty-nine participants with type 2 diabetes (64.5 +/- 6.1 years old) and 34 participants without type 2 diabetes (58.3 +/- 9.2 years old) underwent detailed cognitive assessments and 3-Tesla MRI using intravoxel incoherent motion (IVIM) MRI. Multivariate regression analyses controlling for age, sex, education level, BMI, systolic blood pressure, hematocrit level, and relative hippocampal volume were performed to examine associations between hippocampal IVIM measures, type 2 diabetes (status and FBG), and memory performance. RESULTS: For the microvasculature, blood perfusion volume (f) was larger in participants with type 2 diabetes, f and blood flow (fD*) increased with higher FBG levels, and microvascular pseudodiffusion (D*) and fD*, which are indicative of altered microvasculature, were higher in participants with both relatively high FBG levels and low memory performance. In addition, fD* increased with lower memory performance. For the parenchymal microstructure, the diffusion (D), indicative of injured microstructure, was higher with reduced memory performance. CONCLUSIONS: In addition to the parenchymal microstructure, especially the microvascular properties of the hippocampus are altered in participants with both type 2 diabetes and memory problems and possibly hint at an underlying vascular mechanism.},
   keywords = {Adult
Aged
Case-Control Studies
Cognition Disorders/physiopathology/psychology
Diabetes Mellitus, Type 2/*physiopathology/psychology
Female
Hippocampus/*blood supply
Humans
Magnetic Resonance Angiography/methods
Male
Memory/physiology
Memory Disorders/*physiopathology/psychology
Microvessels/physiology
Middle Aged
Prospective Studies},
   ISSN = {1935-5548 (Electronic)
0149-5992 (Linking)},
   DOI = {10.2337/dc14-2043},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/25690006
https://care.diabetesjournals.org/content/diacare/38/5/876.full.pdf},
   year = {2015},
   type = {Journal Article}
}

@article{RN176,
   author = {van de Haar, H. J. and Burgmans, S. and Hofman, P. A. and Verhey, F. R. and Jansen, J. F. and Backes, W. H.},
   title = {Blood-brain barrier impairment in dementia: current and future in vivo assessments},
   journal = {Neurosci Biobehav Rev},
   volume = {49},
   pages = {71-81},
   note = {van de Haar, Harm J
Burgmans, Saartje
Hofman, Paul A M
Verhey, Frans R J
Jansen, Jacobus F A
Backes, Walter H
eng
Review
2014/12/20 06:00
Neurosci Biobehav Rev. 2015 Feb;49:71-81. doi: 10.1016/j.neubiorev.2014.11.022. Epub 2014 Dec 15.},
   abstract = {Increasing evidence indicates that blood-brain barrier (BBB) impairment may play a role in the pathophysiology of cognitive decline and dementia. In vivo imaging studies are needed to quantify and localize the BBB defects during life, contemplating the circulatory properties. We reviewed the literature for imaging studies investigating BBB impairment in patients suffering from dementia. After selection, 11 imaging studies were included, of which 6 used contrast-enhanced magnetic resonance imaging (MRI), 2 used contrast-enhanced computed tomography (CT), and 3 positron emission tomography (PET). Primarily the MRI studies hint at a subtle increasing permeability of the BBB, particularly in patients already exhibiting cerebrovascular pathology. More elaborate studies are required to provide convincing evidence on BBB impairment in patients with various stages of dementia with and without obvious cerebrovascular pathology. In the future, dynamic contrast enhanced MRI techniques and transport specific imaging using PET may further detail the research on the molecular nature of BBB defects.},
   keywords = {Animals
Blood-Brain Barrier/*pathology/*physiopathology
Dementia/*pathology/*physiopathology
Humans
Alzheimer's disease
Blood-brain barrier
Ct
Contrast-enhanced
Dce-mri
Dementia
Pet
Vascular dementia},
   ISSN = {1873-7528 (Electronic)
0149-7634 (Linking)},
   DOI = {10.1016/j.neubiorev.2014.11.022},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/25524876
https://www.sciencedirect.com/science/article/abs/pii/S0149763414003479?via%3Dihub},
   year = {2015},
   type = {Journal Article}
}

@article{RN177,
   author = {van Veenendaal, T. M. and M., IJff D. and Aldenkamp, A. P. and Hofman, P. A. and Vlooswijk, M. C. and Rouhl, R. P. and de Louw, A. J. and Backes, W. H. and Jansen, J. F.},
   title = {Metabolic and functional MR biomarkers of antiepileptic drug effectiveness: A review},
   journal = {Neurosci Biobehav Rev},
   volume = {59},
   pages = {92-9},
   note = {van Veenendaal, Tamar M
IJff, Dominique M
Aldenkamp, Albert P
Hofman, Paul A M
Vlooswijk, Marielle C G
Rouhl, Rob P W
de Louw, Anton J
Backes, Walter H
Jansen, Jacobus F A
eng
Review
2015/10/18 06:00
Neurosci Biobehav Rev. 2015 Dec;59:92-9. doi: 10.1016/j.neubiorev.2015.10.004. Epub 2015 Oct 22.},
   abstract = {As a large number of patients with epilepsy do not respond favorably to antiepileptic drugs (AEDs), a better understanding of treatment failure and the cause of adverse side effects is required. The working mechanisms of AEDs also alter neurotransmitter concentrations and brain activity, which can be measured using MR spectroscopy and functional MR imaging, respectively. This review presents an overview of clinical research of MR spectroscopy and functional MR imaging studies to the effects of AEDs on the brain. Despite the scarcity of studies associating MR findings to the effectiveness of AEDs, the current research shows clear potential regarding this matter. Several GABAergic AEDs have been shown to increase the GABA concentration, which was related to seizure reductions, while language problems due to topiramate have been associated with altered activation patterns measured with functional MR imaging. MR spectroscopy and functional MR imaging provide biomarkers that may predict individual treatment outcomes, and enable the assessment of mechanisms of treatment failure and cognitive side effects.},
   keywords = {Animals
Anticonvulsants/*therapeutic use
Biomarkers/*analysis
Brain/*drug effects/*physiopathology
Epilepsy/*drug therapy/physiopathology
Humans
Neurotransmitter Agents/metabolism
Treatment Outcome
Anticonvulsant
Cognitive side effects
Functional MRI
MR spectroscopy
Treatment failure},
   ISSN = {1873-7528 (Electronic)
0149-7634 (Linking)},
   DOI = {10.1016/j.neubiorev.2015.10.004},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/26475992
https://www.sciencedirect.com/science/article/abs/pii/S014976341500264X?via%3Dihub},
   year = {2015},
   type = {Journal Article}
}

@article{RN165,
   author = {Besseling, R. M. and Jansen, J. F. and Overvliet, G. M. and van der Kruijs, S. J. and Ebus, S. C. and de Louw, A. J. and Hofman, P. A. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Delayed convergence between brain network structure and function in rolandic epilepsy},
   journal = {Front Hum Neurosci},
   volume = {8},
   pages = {704},
   note = {Besseling, Rene M H
Jansen, Jacobus F A
Overvliet, Geke M
van der Kruijs, Sylvie J M
Ebus, Saskia C M
de Louw, Anton J A
Hofman, Paul A M
Aldenkamp, Albert P
Backes, Walter H
eng
Switzerland
2014/09/25 06:00
Front Hum Neurosci. 2014 Sep 9;8:704. doi: 10.3389/fnhum.2014.00704. eCollection 2014.},
   abstract = {INTRODUCTION: Rolandic epilepsy (RE) manifests during a critical phase of brain development, and has been associated with language impairments. Concordant abnormalities in structural and functional connectivity (SC and FC) have been described before. As SC and FC are under mutual influence, the current study investigates abnormalities in the SC-FC synergy in RE. METHODS: Twenty-two children with RE (age, mean +/- SD: 11.3 +/- 2.0 y) and 22 healthy controls (age 10.5 +/- 1.6 y) underwent structural, diffusion weighted, and resting-state functional magnetic resonance imaging (MRI) at 3T. The probabilistic anatomical landmarks atlas was used to parcellate the (sub)cortical gray matter. Constrained spherical deconvolution tractography and correlation of time series were used to assess SC and FC, respectively. The SC-FC correlation was assessed as a function of age for the non-zero structural connections over a range of sparsity values (0.01-0.75). A modularity analysis was performed on the mean SC network of the controls to localize potential global effects to subnetworks. SC and FC were also assessed separately using graph analysis. RESULTS: The SC-FC correlation was significantly reduced in children with RE compared to healthy controls, especially for the youngest participants. This effect was most pronounced in a left and a right centro-temporal network, as well as in a medial parietal network. Graph analysis revealed no prominent abnormalities in SC or FC network organization. CONCLUSION: Since SC and FC converge during normal maturation, our finding of reduced SC-FC correlation illustrates impaired synergy between brain structure and function. More specifically, since this effect was most pronounced in the youngest participants, RE may represent a developmental disorder of delayed brain network maturation. The observed effects seem especially attributable to medial parietal connections, which forms an intermediate between bilateral centro-temporal modules of epileptiform activity, and bear relevance for language function.},
   keywords = {brain maturation
functional connectivity
graph theory
rolandic epilepsy
structural connectivity
structure-function correlation},
   ISSN = {1662-5161 (Print)
1662-5161 (Linking)},
   DOI = {10.3389/fnhum.2014.00704},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/25249968
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158874/pdf/fnhum-08-00704.pdf},
   year = {2014},
   type = {Journal Article}
}

@article{RN166,
   author = {Braakman, H. M. and Vaessen, M. J. and Jansen, J. F. and Debeij-van Hall, M. H. and de Louw, A. and Hofman, P. A. and Vles, J. S. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Pediatric frontal lobe epilepsy: white matter abnormalities and cognitive impairment},
   journal = {Acta Neurol Scand},
   volume = {129},
   number = {4},
   pages = {252-62},
   note = {Braakman, H M H
Vaessen, M J
Jansen, J F A
Debeij-van Hall, M H J A
de Louw, A
Hofman, P A M
Vles, J S H
Aldenkamp, A P
Backes, W H
eng
Research Support, Non-U.S. Gov't
Denmark
2013/10/12 06:00
Acta Neurol Scand. 2014 Apr;129(4):252-62. doi: 10.1111/ane.12183. Epub 2013 Sep 20.},
   abstract = {OBJECTIVES: Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE). Its etiology remains unknown. With diffusion tensor imaging, we have studied cerebral white matter properties and associations with cognitive functioning in children with FLE and healthy controls. METHODS: Thirty children aged 8-13 years with FLE of unknown cause and 39 healthy age-matched controls underwent neuropsychological assessment, structural and diffusion-weighted brain MRI. Patients were grouped as cognitively impaired or unimpaired, and their white matter diffusion properties were compared with the controls. RESULTS: Children with FLE had reduced apparent diffusion coefficients in various posteriorly located tract bundles, a reduced fractional anisotropy (FA) of the white matter tract between the right frontal and right occipital lobe, and smaller volumes of several collections of interlobar bundle tracts, compared with controls. The cognitively impaired patient group demonstrated significant increases in FA of the white matter of both occipital lobes, a reduced FA of white matter tract bundles between the right frontal and both left occipital lobe and subcortical white matter area, and smaller volumes of two collections of tract bundles connecting the frontal lobe with the temporal and parietal lobes, compared with controls. CONCLUSIONS: Children with FLE had white matter abnormalities mainly in posterior brain regions, not confined to the area of the seizure focus. Cognitively impaired children with FLE showed the most pronounced white matter abnormalities. These possibly reflect disturbed maturation and might be part of the etiology of the cognitive impairment.},
   keywords = {Adolescent
Analysis of Variance
Anisotropy
Brain/*pathology
Case-Control Studies
Child
Cognition Disorders/*complications/diagnosis/*etiology
Diffusion Magnetic Resonance Imaging
Epilepsy, Frontal Lobe/*complications
Female
Humans
Leukoencephalopathies/*complications
Male
Nerve Fibers, Myelinated/pathology
Neuropsychological Tests
Pediatrics
epilepsy
neuroimaging
neuropsychology
pediatric neurology},
   ISSN = {1600-0404 (Electronic)
0001-6314 (Linking)},
   DOI = {10.1111/ane.12183},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/24112290
https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.12183},
   year = {2014},
   type = {Journal Article}
}

@article{RN167,
   author = {Gupta, L. and Besseling, R. M. and Overvliet, G. M. and Hofman, P. A. and de Louw, A. and Vaessen, M. J. and Aldenkamp, A. P. and Ulman, S. and Jansen, J. F. and Backes, W. H.},
   title = {Spatial heterogeneity analysis of brain activation in fMRI},
   journal = {Neuroimage Clin},
   volume = {5},
   pages = {266-76},
   note = {Gupta, Lalit
Besseling, Rene M H
Overvliet, Geke M
Hofman, Paul A M
de Louw, Anton
Vaessen, Maarten J
Aldenkamp, Albert P
Ulman, Shrutin
Jansen, Jacobus F A
Backes, Walter H
eng
Netherlands
2014/08/28 06:00
Neuroimage Clin. 2014 Jul 6;5:266-76. doi: 10.1016/j.nicl.2014.06.013. eCollection 2014.},
   abstract = {In many brain diseases it can be qualitatively observed that spatial patterns in blood oxygenation level dependent (BOLD) activation maps appear more (diffusively) distributed than in healthy controls. However, measures that can quantitatively characterize this spatial distributiveness in individual subjects are lacking. In this study, we propose a number of spatial heterogeneity measures to characterize brain activation maps. The proposed methods focus on different aspects of heterogeneity, including the shape (compactness), complexity in the distribution of activated regions (fractal dimension and co-occurrence matrix), and gappiness between activated regions (lacunarity). To this end, functional MRI derived activation maps of a language and a motor task were obtained in language impaired children with (Rolandic) epilepsy and compared to age-matched healthy controls. Group analysis of the activation maps revealed no significant differences between patients and controls for both tasks. However, for the language task the activation maps in patients appeared more heterogeneous than in controls. Lacunarity was the best measure to discriminate activation patterns of patients from controls (sensitivity 74%, specificity 70%) and illustrates the increased irregularity of gaps between activated regions in patients. The combination of heterogeneity measures and a support vector machine approach yielded further increase in sensitivity and specificity to 78% and 80%, respectively. This illustrates that activation distributions in impaired brains can be complex and more heterogeneous than in normal brains and cannot be captured fully by a single quantity. In conclusion, heterogeneity analysis has potential to robustly characterize the increased distributiveness of brain activation in individual patients.},
   keywords = {Adolescent
Algorithms
Brain/*physiopathology
Brain Mapping/*methods
Child
Epilepsy, Rolandic/physiopathology
Female
Humans
Image Interpretation, Computer-Assisted/*methods
Magnetic Resonance Imaging/*methods
Male
Spatial Analysis
Activation patterns
BOLD activation maps
Co-occurrence Matrix
Fractal dimensions
Functional magnetic resonance imaging
Lacunarity
Spatial heterogeneity},
   ISSN = {2213-1582 (Print)
2213-1582 (Linking)},
   DOI = {10.1016/j.nicl.2014.06.013},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/25161893
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141984/pdf/main.pdf},
   year = {2014},
   type = {Journal Article}
}

@article{RN168,
   author = {Jansen, J. F. and van der Kruijs, S. J. and Vlooswijk, M. C. and Majoie, H. M. and Hofman, P. A. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Quantitative MR and cognitive impairment in cryptogenic localisation-related epilepsy},
   journal = {Epileptic Disord},
   volume = {16},
   number = {3},
   pages = {318-27},
   note = {Jansen, Jacobus Fa
van der Kruijs, Sylvie Jm
Vlooswijk, Marielle Cg
Majoie, Hj Marian
Hofman, Paul Am
Aldenkamp, Albert P
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
France
2014/07/19 06:00
Epileptic Disord. 2014 Sep;16(3):318-27. doi: 10.1684/epd.2014.0665.},
   abstract = {For patients with chronic cryptogenic localisation-related epilepsy (CLRE), conventional MRI does not provide measures to discern between patients with or without cognitive complaints. We investigated, in a preliminary study, whether it is possible to detect cerebral biomarkers of cognitive impairment in patients with CLRE using sensitive quantitative MRI techniques. Neuropsychological assessment and quantitative 3.0 T MRI, comprising T2 relaxometry, diffusion tensor imaging, and spectroscopic imaging, were applied to 35 patients with CLRE and 21 healthy controls. Analysis included the left and right hippocampi, and frontal and temporal lobes. Differences between the groups and correlations with cognitive and clinical characteristics were assessed. Patients with epilepsy scored significantly worse on cognitive tasks compared to healthy controls. Significantly larger CSF fractions in the hippocampi and left temporal lobe, a longer T2 relaxation time in the left hippocampus, and a significantly higher concentration of glutamate/glutamine in the left frontal lobe were observed in patients with epilepsy. Moreover, poor memory performance was significantly correlated with larger CSF fractions in the right hippocampus and left temporal lobe in patients. In the temporal lobe, an association between subtle changes in morphology (indicative of atrophy) and memory performance was found, consistent with previous literature. These results may help to explain the alterations in brain functioning in patients with epilepsy.},
   keywords = {Adult
Cognition
Cognition Disorders/etiology/*pathology/psychology
Diffusion Tensor Imaging
Epilepsy/complications/*pathology/psychology
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Spectroscopy
Male
Middle Aged
Neuropsychological Tests
MR spectroscopy
MRI-negative
localization-related epilepsy
memory},
   ISSN = {1294-9361 (Print)
1294-9361 (Linking)},
   DOI = {10.1684/epd.2014.0665},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/25036856
http://www.jle.com/download/epd-302156-25932-quantitative_mr_and_cognitive_impairment_in_cryptogenic_localisation_related_epilepsy-a.pdf},
   year = {2014},
   type = {Journal Article}
}

@article{RN169,
   author = {Matulewicz, L. and Jansen, J. F. and Bokacheva, L. and Vargas, H. A. and Akin, O. and Fine, S. W. and Shukla-Dave, A. and Eastham, J. A. and Hricak, H. and Koutcher, J. A. and Zakian, K. L.},
   title = {Anatomic segmentation improves prostate cancer detection with artificial neural networks analysis of 1H magnetic resonance spectroscopic imaging},
   journal = {J Magn Reson Imaging},
   volume = {40},
   number = {6},
   pages = {1414-21},
   note = {Matulewicz, Lukasz
Jansen, Jacobus F A
Bokacheva, Louisa
Vargas, Hebert Alberto
Akin, Oguz
Fine, Samson W
Shukla-Dave, Amita
Eastham, James A
Hricak, Hedvig
Koutcher, Jason A
Zakian, Kristen L
eng
R01 CA076423/CA/NCI NIH HHS/
R01 CA76423/CA/NCI NIH HHS/
Evaluation Study
Research Support, N.I.H., Extramural
2013/11/19 06:00
J Magn Reson Imaging. 2014 Dec;40(6):1414-21. doi: 10.1002/jmri.24487. Epub 2013 Nov 15.},
   abstract = {PURPOSE: To assess whether an artificial neural network (ANN) model is a useful tool for automatic detection of cancerous voxels in the prostate from (1)H-MRSI datasets and whether the addition of information about anatomical segmentation improves the detection of cancer. MATERIALS AND METHODS: The Institutional Review Board approved this HIPAA-compliant study and waived informed consent. Eighteen men with prostate cancer (median age, 55 years; range, 36-71 years) who underwent endorectal MRI/MRSI before radical prostatectomy were included in this study. These patients had at least one cancer area on whole-mount histopathological map and at least one matching MRSI voxel suspicious for cancer detected. Two ANN models for automatic classification of MRSI voxels in the prostate were implemented and compared: model 1, which used only spectra as input, and model 2, which used the spectra plus information from anatomical segmentation. The models were trained, tested and validated using spectra from voxels that the spectroscopist had designated as cancer and that were verified on histopathological maps. RESULTS: At ROC analysis, model 2 (AUC = 0.968) provided significantly better (P = 0.03) classification of cancerous voxels than did model 1 (AUC = 0.949). CONCLUSION: Automatic analysis of prostate MRSI to detect cancer using ANN model is feasible. Application of anatomical segmentation from MRI as an additional input to ANN improves the accuracy of detecting cancerous voxels from MRSI.},
   keywords = {Adult
Aged
Algorithms
Biomarkers, Tumor/*analysis
Humans
Image Enhancement/methods
Magnetic Resonance Imaging/*methods
Male
Middle Aged
*Neural Networks, Computer
Pattern Recognition, Automated/*methods
Prostatic Neoplasms/*chemistry/*diagnosis
Proton Magnetic Resonance Spectroscopy/*methods
Reproducibility of Results
Sensitivity and Specificity
computer-aided diagnosis
magnetic resonance spectroscopic imaging
neural networks
pattern recognition
prostate cancer},
   ISSN = {1522-2586 (Electronic)
1053-1807 (Linking)},
   DOI = {10.1002/jmri.24487},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/24243554
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306557/pdf/nihms532784.pdf},
   year = {2014},
   type = {Journal Article}
}

@article{RN293,
   author = {Schram, M. T. and Sep, S. J. and van der Kallen, C. J. and Dagnelie, P. C. and Koster, A. and Schaper, N. and Henry, R. M. and Stehouwer, C. D.},
   title = {The Maastricht Study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities},
   journal = {Eur J Epidemiol},
   volume = {29},
   number = {6},
   pages = {439-51},
   note = {Schram, Miranda T
Sep, Simone J S
van der Kallen, Carla J
Dagnelie, Pieter C
Koster, Annemarie
Schaper, Nicolaas
Henry, Ronald M A
Stehouwer, Coen D A
eng
Research Support, Non-U.S. Gov't
Netherlands
Eur J Epidemiol. 2014 Jun;29(6):439-51. doi: 10.1007/s10654-014-9889-0. Epub 2014 Apr 23.},
   abstract = {The Maastricht Study is an extensive phenotyping study that focuses on the etiology of type 2 diabetes (T2DM), its classic complications, and its emerging comorbidities. The study uses state-of-the-art imaging techniques and extensive biobanking to determine health status in a population-based cohort of 10,000 individuals that is enriched with T2DM individuals. Enrollment started in November 2010 and is anticipated to last 5-7 years. The Maastricht Study is expected to become one of the most extensive phenotyping studies in both the general population and T2DM participants world-wide. The Maastricht study will specifically focus on possible mechanisms that may explain why T2DM accelerates the development and progression of classic complications, such as cardiovascular disease, retinopathy, neuropathy and nephropathy and of emerging comorbidities, such as cognitive decline, depression, and gastrointestinal, musculoskeletal and respiratory diseases. In addition, it will also examine the association of these variables with quality of life and use of health care resources. This paper describes the rationale, overall study design, recruitment strategy and methods of basic measurements, and gives an overview of all measurements that are performed within The Maastricht Study.},
   keywords = {Adult
Aged
Cardiovascular Diseases/complications/epidemiology/etiology
Comorbidity
Diabetes Mellitus, Type 2/complications/*epidemiology/*etiology
Female
Humans
*Life Style
Male
Middle Aged
Netherlands/epidemiology
*Phenotype
Population Surveillance
Prospective Studies
Risk Factors
*Social Support
Socioeconomic Factors},
   ISSN = {1573-7284 (Electronic)
0393-2990 (Linking)},
   DOI = {10.1007/s10654-014-9889-0},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/24756374},
   year = {2014},
   type = {Journal Article}
}

@article{RN170,
   author = {Vaessen, M. J. and Jansen, J. F. and Braakman, H. M. and Hofman, P. A. and De Louw, A. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Functional and structural network impairment in childhood frontal lobe epilepsy},
   journal = {PLoS One},
   volume = {9},
   number = {3},
   pages = {e90068},
   note = {Vaessen, Maarten J
Jansen, Jacobus F A
Braakman, Hilde M H
Hofman, Paul A M
De Louw, Anton
Aldenkamp, Albert P
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2014/03/07 06:00
PLoS One. 2014 Mar 4;9(3):e90068. doi: 10.1371/journal.pone.0090068. eCollection 2014.},
   abstract = {In childhood frontal lobe epilepsy (FLE), cognitive impairment and educational underachievement are serious, well-known co-morbidities. The broad scale of affected cognitive domains suggests wide-spread network disturbances that not only involves, but also extends beyond the frontal lobe. In this study we have investigated whole brain connectional properties of children with FLE in relation to their cognitive impairment and compared them with healthy controls. Functional connectivity (FC) of the networks was derived from dynamic fluctuations of resting state fMRI and structural connectivity (SC) was obtained from fiber tractograms of diffusion weighted MRI. The whole brain network was characterized with graph theoretical metrics and decomposed into modules. Subsequently, the graph metrics and the connectivity within and between modules were related to cognitive performance. Functional network disturbances in FLE were related to increased clustering, increased path length, and stronger modularity compared to healthy controls, which was accompanied by stronger within- and weaker between-module functional connectivity. Although structural path length and clustering appeared normal in children with FLE, structural modularity increased with stronger cognitive impairment. It is concluded that decreased coupling between large-scale functional network modules is a hallmark for impaired cognition in childhood FLE.},
   keywords = {Adolescent
Aging/pathology
Case-Control Studies
Child
Cognition Disorders/complications/physiopathology
Epilepsy, Frontal Lobe/complications/*pathology/*physiopathology
Humans
Magnetic Resonance Imaging
Nerve Net/*pathology/*physiopathology},
   ISSN = {1932-6203 (Electronic)
1932-6203 (Linking)},
   DOI = {10.1371/journal.pone.0090068},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/24594874
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942412/pdf/pone.0090068.pdf},
   year = {2014},
   type = {Journal Article}
}

@article{RN171,
   author = {van der Kruijs, S. J. and Bodde, N. M. and Carrette, E. and Lazeron, R. H. and Vonck, K. E. and Boon, P. A. and Langereis, G. R. and Cluitmans, P. J. and Feijs, L. M. and Hofman, P. A. and Backes, W. H. and Jansen, J. F. and Aldenkamp, A. P.},
   title = {Neurophysiological correlates of dissociative symptoms},
   journal = {J Neurol Neurosurg Psychiatry},
   volume = {85},
   number = {2},
   pages = {174-9},
   note = {van der Kruijs, Sylvie J M
Bodde, Nynke M G
Carrette, Evelien
Lazeron, Richard H C
Vonck, Kristl E J
Boon, Paul A J M
Langereis, Geert R
Cluitmans, Pierre J M
Feijs, Loe M G
Hofman, Paul A M
Backes, Walter H
Jansen, Jacobus F A
Aldenkamp, A P
eng
Review
England
2012/11/24 06:00
J Neurol Neurosurg Psychiatry. 2014 Feb;85(2):174-9. doi: 10.1136/jnnp-2012-302905. Epub 2012 Nov 22.},
   abstract = {OBJECTIVE: Dissociation is a mental process with psychological and somatoform manifestations, which is closely related to hypnotic suggestibility and essentially shows the ability to obtain distance from reality. An increased tendency to dissociate is a frequently reported characteristic of patients with functional neurological symptoms and syndromes (FNSS), which account for a substantial part of all neurological admissions. This review aims to investigate what heart rate variability (HRV), EEG and neuroimaging data (MRI) reveal about the nature of dissociation and related conditions. METHODS: Studies reporting HRV, EEG and neuroimaging data related to hypnosis, dissociation and FNSS were identified by searching the electronic databases Pubmed and ScienceDirect. RESULTS: The majority of the identified studies concerned the physiological characteristics of hypnosis; relatively few investigations on dissociation related FNSS were identified. General findings were increased parasympathetic functioning during hypnosis (as measured by HRV), and lower HRV in patients with FNSS. The large variety of EEG and functional MRI investigations with diverse results challenges definite conclusions, but evidence suggests that subcortical as well as (pre)frontal regions serve emotion regulation in dissociative conditions. Functional connectivity analyses suggest the presence of altered brain networks in patients with FNSS, in which limbic areas have an increased influence on motor preparatory regions. CONCLUSIONS: HRV, EEG and (functional) MRI are sensitive methods to detect physiological changes related to dissociation and dissociative disorders such as FNSS, and can possibly provide more information about their aetiology. The use of such measures could eventually provide biomarkers for earlier identification of patients at risk and appropriate treatment of dissociative conditions.},
   keywords = {Brain/physiology/*physiopathology
Brain Waves/*physiology
Dissociative Disorders/complications/*physiopathology
*Functional Neuroimaging
Heart Rate/*physiology
Humans
Hypnosis
Nervous System Diseases/complications/*physiopathology/psychology
Eeg
Functional Imaging
Neurophysiology
Somatisation Disorder},
   ISSN = {1468-330X (Electronic)
0022-3050 (Linking)},
   DOI = {10.1136/jnnp-2012-302905},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/23175855
https://jnnp.bmj.com/content/85/2/174.long},
   year = {2014},
   type = {Journal Article}
}

@article{RN172,
   author = {van der Kruijs, S. J. and Jagannathan, S. R. and Bodde, N. M. and Besseling, R. M. and Lazeron, R. H. and Vonck, K. E. and Boon, P. A. and Cluitmans, P. J. and Hofman, P. A. and Backes, W. H. and Aldenkamp, A. P. and Jansen, J. F.},
   title = {Resting-state networks and dissociation in psychogenic non-epileptic seizures},
   journal = {J Psychiatr Res},
   volume = {54},
   pages = {126-33},
   note = {van der Kruijs, Sylvie J M
Jagannathan, Sridhar R
Bodde, Nynke M G
Besseling, Rene M H
Lazeron, Richard H C
Vonck, Kristl E J
Boon, Paul A J M
Cluitmans, Pierre J M
Hofman, Paul A M
Backes, Walter H
Aldenkamp, Albert P
Jansen, Jacobus F A
eng
England
2014/04/08 06:00
J Psychiatr Res. 2014 Jul;54:126-33. doi: 10.1016/j.jpsychires.2014.03.010. Epub 2014 Mar 21.},
   abstract = {OBJECTIVE: Psychogenic non-epileptic seizures (PNES) are epilepsy-like episodes which have an emotional rather than organic origin. Although PNES have often been related to the process of dissociation, the psychopathology is still poorly understood. To elucidate underlying mechanisms, the current study applied independent component analysis (ICA) on resting-state fMRI to investigate alterations within four relevant networks, associated with executive, fronto-parietal, sensorimotor, and default mode activation, and within a visual network to examine specificity of between-group differences. METHODS: Twenty-one patients with PNES without psychiatric or neurologic comorbidities and twenty-seven healthy controls underwent resting-state functional MR imaging at 3.0T (Philips Achieva). Additional neuropsychological testing included Raven's Matrices test and dissociation questionnaires. ICA with dual regression was used to identify resting-state networks in all participants, and spatial maps of the networks of interest were compared between patients and healthy controls. RESULTS: Patients displayed higher dissociation scores, lower cognitive performance and increased contribution of the orbitofrontal, insular and subcallosal cortex in the fronto-parietal network; the cingulate and insular cortex in the executive control network; the cingulate gyrus, superior parietal lobe, pre- and postcentral gyri and supplemental motor cortex in the sensorimotor network; and the precuneus and (para-) cingulate gyri in the default-mode network. The connectivity strengths within these regions of interest significantly correlated with dissociation scores. No between-group differences were found within the visual network, which was examined to determine specificity of between-group differences. CONCLUSIONS: PNES patients displayed abnormalities in several resting-state networks that provide neuronal correlates for an underlying dissociation mechanism.},
   keywords = {Adult
Brain/blood supply/*pathology
*Brain Mapping
Dissociative Disorders/*etiology
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Oxygen/blood
Psychophysiologic Disorders/*physiopathology
*Rest
*Seizures/complications/pathology/psychology
Statistics as Topic
Surveys and Questionnaires
Dissociation
Independent component analysis
Psychogenic non-epileptic seizures
Resting-state networks},
   ISSN = {1879-1379 (Electronic)
0022-3956 (Linking)},
   DOI = {10.1016/j.jpsychires.2014.03.010},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/24703187
https://www.sciencedirect.com/science/article/abs/pii/S0022395614000831?via%3Dihub},
   year = {2014},
   type = {Journal Article}
}

@article{RN236,
   author = {van der Kruijs, S. J. and Vonck, K. E. and Feijs, L. M. and Bodde, N. M. and Lazeron, R. H. and Carrette, E. and Boon, P. A. and Backes, W. H. and Jansen, J. F. and Aldenkamp, A. P. and Cluitmans, P. J.},
   title = {Autonomic nervous system functioning associated with epileptic seizures: Analysis of heart rate variability},
   journal = {J Neurol Neurophysiol},
   volume = {5},
   number = {4},
   pages = {1000215},
   abstract = {Objective: Little is known about the (peri-) ictal changes in autonomic nervous system activity of epileptic
seizures. Such information may be useful for seizure prediction paradigms and differential diagnosis between
epilepsy and psychogenic non-epileptic seizures (PNES). The current study investigated the peri-ictal time course of
heart rate variability (HRV) measures, which reflect autonomic nervous system functioning.
Methods: HRV measures were extracted from electrocardiography data collected during 1-7 days of videoelectroencephalography
monitoring of 17 patients with epilepsy and 20 patients with PNES. Heart rate (HR) and
HRV measures (standard deviation of average beat-to-beat intervals (SDANN), root mean square of successive
differences (RMSSD), high frequency (HF) power, low frequency (LF) power and very low frequency (VLF) power)
were averaged over consecutive five-minute intervals. Quantitative analyses of Poincaré plot parameters (SD1, SD2
and SD1/SD2 ratio) were also performed. In addition, differences with HRV parameters of patients with PNES were
explored.
Results: In epilepsy, no significant pre-ictal changes in HR and HRV parameters were observed. During
seizures, HR, SDANN, SD1 and SD1/SD2 ratio significantly increased while VLF power significantly decreased. In
the five-minute interval immediately following seizures, HR, SDANN and SD1 were back to pre-seizure levels, while
VLF power remained significantly decreased and SD1/SD2 ratio remained significantly increased. Significant
between-group differences were identified for several pre-ictal and ictal HRV parameters, but not for post-ictal
measurements.
Conclusion: The ictal HR and HRV changes reflect increased sympathetic system activation during epileptic
seizures. The HRV parameters of patients with epilepsy differed significantly from the peri-ictal HRV pattern of
patients with PNES, which suggested increased sympathetic system activation and decreased vagal tone shortly
before PNES and return to normal levels shortly after the episode. Implications for differential diagnosis and
treatment are discussed.},
   keywords = {Epilepsy
Psychogenic
Non-epileptic seizures
Heart rate variability
Vagal tone
Autonomic nervous system},
   ISSN = {2155-9562},
   DOI = {10.4172/2155-9562-5-1000215},
   url = {https://www.omicsonline.org/open-access/autonomic-nervous-system-functioning-associated-with-epileptic-seizures-analysis-of-heart-rate-variability-2155-9562-5-1000215.php?aid=30282},
   year = {2014},
   type = {Journal Article}
}

@article{RN156,
   author = {Barendse, E. M. and Hendriks, M. P. and Jansen, J. F. and Backes, W. H. and Hofman, P. A. and Thoonen, G. and Kessels, R. P. and Aldenkamp, A. P.},
   title = {Working memory deficits in high-functioning adolescents with autism spectrum disorders: neuropsychological and neuroimaging correlates},
   journal = {J Neurodev Disord},
   volume = {5},
   number = {1},
   pages = {14},
   note = {Barendse, Evelien M
Hendriks, Marc Ph
Jansen, Jacobus Fa
Backes, Walter H
Hofman, Paul Am
Thoonen, Geert
Kessels, Roy Pc
Aldenkamp, Albert P
eng
England
2013/06/05 06:00
J Neurodev Disord. 2013 Jun 4;5(1):14. doi: 10.1186/1866-1955-5-14.},
   abstract = {Working memory is a temporary storage system under attentional control. It is believed to play a central role in online processing of complex cognitive information and may also play a role in social cognition and interpersonal interactions. Adolescents with a disorder on the autism spectrum display problems in precisely these domains. Social impairments, communication difficulties, and repetitive interests and activities are core domains of autism spectrum disorders (ASD), and executive function problems are often seen throughout the spectrum. As the main cognitive theories of ASD, including the theory of mind deficit hypotheses, weak central coherence account, and the executive dysfunction theory, still fail to explain the broad spectrum of symptoms, a new perspective on the etiology of ASD is needed. Deficits in working memory are central to many theories of psychopathology, and are generally linked to frontal-lobe dysfunction. This article will review neuropsychological and (functional) brain imaging studies on working memory in adolescents with ASD. Although still disputed, it is concluded that within the working memory system specific problems of spatial working memory are often seen in adolescents with ASD. These problems increase when information is more complex and greater demands on working memory are made. Neuroimaging studies indicate a more global working memory processing or connectivity deficiency, rather than a focused deficit in the prefrontal cortex. More research is needed to relate these working memory difficulties and neuroimaging results in ASD to the behavioral difficulties as seen in individuals with a disorder on the autism spectrum.},
   ISSN = {1866-1947 (Print)
1866-1947 (Linking)},
   DOI = {10.1186/1866-1955-5-14},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/23731472
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674927/pdf/1866-1955-5-14.pdf},
   year = {2013},
   type = {Journal Article}
}

@article{RN157,
   author = {Besseling, R. M. and Jansen, J. F. and Overvliet, G. M. and van der Kruijs, S. J. and Ebus, S. C. and de Louw, A. and Hofman, P. A. and Vles, J. S. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Reduced structural connectivity between sensorimotor and language areas in rolandic epilepsy},
   journal = {PLoS One},
   volume = {8},
   number = {12},
   pages = {e83568},
   note = {Besseling, Rene M H
Jansen, Jacobus F A
Overvliet, Geke M
van der Kruijs, Sylvie J M
Ebus, Saskia C M
de Louw, Anton
Hofman, Paul A M
Vles, Johannes S H
Aldenkamp, Albert P
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2014/01/01 06:00
PLoS One. 2013 Dec 23;8(12):e83568. doi: 10.1371/journal.pone.0083568. eCollection 2013.},
   abstract = {INTRODUCTION: Rolandic epilepsy (RE) is a childhood epilepsy with centrotemporal (rolandic) spikes, that is increasingly associated with language impairment. In this study, we tested for a white matter (connectivity) correlate, employing diffusion weighted MRI and language testing. METHODS: Twenty-three children with RE and 23 matched controls (age: 8-14 years) underwent structural (T1-weighted) and diffusion-weighted MRI (b = 1200 s/mm(2), 66 gradient directions) at 3T, as well as neuropsychological language testing. Combining tractography and a cortical segmentation derived from the T1-scan, the rolandic tract were reconstructed (pre- and postcentral gyri), and tract fractional anisotropy (FA) values were compared between patients and controls. Aberrant tracts were tested for correlations with language performance. RESULTS: Several reductions of tract FA were found in patients compared to controls, mostly in the left hemisphere; the most significant effects involved the left inferior frontal (p = 0.005) and supramarginal (p = 0.004) gyrus. In the patient group, lower tract FA values were correlated with lower language performance, among others for the connection between the left postcentral and inferior frontal gyrus (p = 0.043, R = 0.43). CONCLUSION: In RE, structural connectivity is reduced for several connections involving the rolandic regions, from which the epileptiform activity originates. Most of these aberrant tracts involve the left (typically language mediating) hemisphere, notably the pars opercularis of the inferior frontal gyrus (Broca's area) and the supramarginal gyrus (Wernicke's area). For the former, reduced language performance for lower tract FA was found in the patients. These findings provide a first microstructural white matter correlate for language impairment in RE.},
   keywords = {Adolescent
Anisotropy
Case-Control Studies
Child
Diffusion Tensor Imaging
Epilepsy, Rolandic/*pathology/physiopathology
Female
Humans
*Language
Language Tests
Male
Sensorimotor Cortex/*pathology/physiopathology
White Matter/*pathology/physiopathology},
   ISSN = {1932-6203 (Electronic)
1932-6203 (Linking)},
   DOI = {10.1371/journal.pone.0083568},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/24376719
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871667/pdf/pone.0083568.pdf},
   year = {2013},
   type = {Journal Article}
}

@article{RN158,
   author = {Besseling, R. M. and Jansen, J. F. and Overvliet, G. M. and van der Kruijs, S. J. and Vles, J. S. and Ebus, S. C. and Hofman, P. A. and Louw, Ad and Aldenkamp, A. P. and Backes, W. H.},
   title = {Reduced functional integration of the sensorimotor and language network in rolandic epilepsy},
   journal = {Neuroimage Clin},
   volume = {2},
   pages = {239-46},
   note = {Besseling, Rene M H
Jansen, Jacobus F A
Overvliet, Geke M
van der Kruijs, Sylvie J M
Vles, Johannes S H
Ebus, Saskia C M
Hofman, Paul A M
Louw, Anton de
Aldenkamp, Albert P
Backes, Walter H
eng
Netherlands
2013/11/02 06:00
Neuroimage Clin. 2013 Jan 18;2:239-46. doi: 10.1016/j.nicl.2013.01.004. eCollection 2013.},
   abstract = {INTRODUCTION: Over the last years, evidence has accumulated that rolandic epilepsy (RE) is associated with serious cognitive comorbidities, including language impairment. However, the cerebral mechanism through which epileptiform activity in the rolandic (sensorimotor) areas may affect the language system is unknown. To investigate this, the connectivity between rolandic areas and regions involved in language processing is studied using functional MRI (fMRI). MATERIALS AND METHODS: fMRI data was acquired from 22 children with rolandic epilepsy and 22 age-matched controls (age range: 8-14 years), both at rest and using word-generation and reading tasks. Activation map analysis revealed no group differences (FWE-corrected, p < 0.05) and was therefore used to define regions of interest for pooled (patients and controls combined) language activation. Independent component analysis with dual regression was used to identify the sensorimotor resting-state network in all subjects. The associated functional connectivity maps were compared between groups at the regions of interest for language activation identified from the task data. In addition, neuropsychological language testing (Clinical Evaluation of Language Fundamentals, 4th edition) was performed. RESULTS: Functional connectivity with the sensorimotor network was reduced in patients compared to controls (p = 0.011) in the left inferior frontal gyrus, i.e. Broca's area as identified by the word-generation task. No aberrant functional connectivity values were found in the other regions of interest, nor were any associations found between functional connectivity and language performance. Neuropsychological testing confirmed language impairment in patients relative to controls (reductions in core language score, p = 0.03; language content index, p = 0.01; receptive language index, p = 0.005). CONCLUSION: Reduced functional connectivity was demonstrated between the sensorimotor network and the left inferior frontal gyrus (Broca's area) in children with RE, which might link epileptiform activity/seizures originating from the sensorimotor cortex to language impairment, and is in line with the identified neuropsychological profile of anterior language dysfunction.},
   keywords = {ICA, independent component analysis
Independent component analysis
Language impairment
RE, rolandic epilepsy
Resting-state fMRI
Resting-state networks
Rolandic epilepsy
Sensorimotor/rolandic network},
   ISSN = {2213-1582 (Print)
2213-1582 (Linking)},
   DOI = {10.1016/j.nicl.2013.01.004},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/24179777
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777786/pdf/main.pdf},
   year = {2013},
   type = {Journal Article}
}

@article{RN159,
   author = {Besseling, R. M. and Overvliet, G. M. and Jansen, J. F. and van der Kruijs, S. J. and Vles, J. S. and Ebus, S. C. and Hofman, P. A. and de Louw, A. J. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Aberrant functional connectivity between motor and language networks in rolandic epilepsy},
   journal = {Epilepsy Res},
   volume = {107},
   number = {3},
   pages = {253-62},
   note = {Besseling, Rene M H
Overvliet, Geke M
Jansen, Jacobus F A
van der Kruijs, Sylvie J M
Vles, Johannes S H
Ebus, Saskia C M
Hofman, Paul A M
de Louw, Anton J A
Aldenkamp, Albert P
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
Netherlands
2013/11/12 06:00
Epilepsy Res. 2013 Dec;107(3):253-62. doi: 10.1016/j.eplepsyres.2013.10.008. Epub 2013 Oct 23.},
   abstract = {INTRODUCTION: Rolandic epilepsy (RE) is an idiopathic focal childhood epilepsy with a well-established neuropsychological profile of language impairment. The aim of this study is to provide a functional correlate that links rolandic (sensorimotor) pathology to language problems using functional MRI. MATERIALS AND METHODS: Twenty-three children with RE (8-14 years old) and 21 matched controls underwent extensive language assessment (Clinical Evaluation of Language Fundamentals). fMRI was performed at rest and using word generation, reading, and finger tapping paradigms. Since no activation group differences were found, regions of interest (ROIs) were defined at pooled (patients and controls combined) activation maxima and in contralateral homotopic cortex, and used to assess language lateralization as well as for a resting-state connectivity analysis. Furthermore, the association between connection strength and language performance was investigated. RESULTS: Reduced language performance was found in the children with RE. Bilateral activation was found for both language tasks with some predominance of the left hemisphere in both groups. Compared to controls, patient connectivity was decreased between the left sensorimotor area and right inferior frontal gyrus (p<0.01). For this connection, lower connectivity was associated with lower language scores in the patient group (r=0.49, p=0.02), but not in the controls. CONCLUSION: Language laterality analysis revealed bilateral language representation in the age range under study (8-14 years). As a consequence, the connection of reduced functional connectivity we found represents an impaired interplay between motor and language networks, and aberrant functional connectivity associated with poorer language performance. These findings provide a first neuronal correlate in terms of aberrant resting-state functional connectivity for language impairment in RE.},
   keywords = {Adolescent
Cerebral Cortex/*pathology/physiology
Child
Epilepsy, Rolandic/*diagnosis/physiopathology
Female
Humans
*Language
Language Tests
Magnetic Resonance Imaging/methods
Male
Nerve Net/*pathology/*physiology
Psychomotor Performance/*physiology
Sensory Gating/physiology
Benign rolandic epilepsy of childhood with centro temporal spikes
Language impairment
Re
Resting-state functional MRI
rolandic epilepsy},
   ISSN = {1872-6844 (Electronic)
0920-1211 (Linking)},
   DOI = {10.1016/j.eplepsyres.2013.10.008},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/24210960
https://www.sciencedirect.com/science/article/abs/pii/S0920121113002623?via%3Dihub},
   year = {2013},
   type = {Journal Article}
}

@article{RN160,
   author = {Braakman, H. M. and Vaessen, M. J. and Jansen, J. F. and Debeij-van Hall, M. H. and de Louw, A. and Hofman, P. A. and Vles, J. S. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Frontal lobe connectivity and cognitive impairment in pediatric frontal lobe epilepsy},
   journal = {Epilepsia},
   volume = {54},
   number = {3},
   pages = {446-54},
   note = {Braakman, Hilde M H
Vaessen, Maarten J
Jansen, Jacobus F A
Debeij-van Hall, Mariette H J A
de Louw, Anton
Hofman, Paul A M
Vles, Johan S H
Aldenkamp, Albert P
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2012/12/21 06:00
Epilepsia. 2013 Mar;54(3):446-54. doi: 10.1111/epi.12044. Epub 2012 Dec 17.},
   abstract = {PURPOSE: Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE), but its etiology is unknown. With functional magnetic resonance imaging (fMRI), we have explored the relationship between brain activation, functional connectivity, and cognitive functioning in a cohort of pediatric patients with FLE and healthy controls. METHODS: Thirty-two children aged 8-13 years with FLE of unknown cause and 41 healthy age-matched controls underwent neuropsychological assessment and structural and functional brain MRI. We investigated to which extent brain regions activated in response to a working memory task and assessed functional connectivity between distant brain regions. Data of patients were compared to controls, and patients were grouped as cognitively impaired or unimpaired. KEY FINDINGS: Children with FLE showed a global decrease in functional brain connectivity compared to healthy controls, whereas brain activation patterns in children with FLE remained relatively intact. Children with FLE complicated by cognitive impairment typically showed a decrease in frontal lobe connectivity. This decreased frontal lobe connectivity comprised both connections within the frontal lobe as well as connections from the frontal lobe to the parietal lobe, temporal lobe, cerebellum, and basal ganglia. SIGNIFICANCE: Decreased functional frontal lobe connectivity is associated with cognitive impairment in pediatric FLE. The importance of impairment of functional integrity within the frontal lobe network, as well as its connections to distant areas, provides new insights in the etiology of the broad-range cognitive impairments in children with FLE.},
   keywords = {Adolescent
Child
Cognition Disorders/*epidemiology/*physiopathology/psychology
Cohort Studies
Epilepsy, Frontal Lobe/*epidemiology/*physiopathology/psychology
Female
Frontal Lobe/*physiology
Humans
Male
Nerve Net/*physiology
Neural Pathways/physiology
Photic Stimulation/methods
Psychomotor Performance/physiology
Registries},
   ISSN = {1528-1167 (Electronic)
0013-9580 (Linking)},
   DOI = {10.1111/epi.12044},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/23253092
https://onlinelibrary.wiley.com/doi/full/10.1111/epi.12044},
   year = {2013},
   type = {Journal Article}
}

@article{RN161,
   author = {Lu, Y. and Jansen, J. F. and Stambuk, H. E. and Gupta, G. and Lee, N. and Gonen, M. and Moreira, A. and Mazaheri, Y. and Patel, S. G. and Deasy, J. O. and Shah, J. P. and Shukla-Dave, A.},
   title = {Comparing primary tumors and metastatic nodes in head and neck cancer using intravoxel incoherent motion imaging: a preliminary experience},
   journal = {J Comput Assist Tomogr},
   volume = {37},
   number = {3},
   pages = {346-52},
   note = {Lu, Yonggang
Jansen, Jacobus F A
Stambuk, Hilda E
Gupta, Gaorav
Lee, Nancy
Gonen, Mithat
Moreira, Andre
Mazaheri, Yousef
Patel, Snehal G
Deasy, Joseph O
Shah, Jatin P
Shukla-Dave, Amita
eng
P30 CA008748/CA/NCI NIH HHS/
R01 CA115895/CA/NCI NIH HHS/
1 R01 CA115895/CA/NCI NIH HHS/
Comparative Study
Research Support, N.I.H., Extramural
2013/05/16 06:00
J Comput Assist Tomogr. 2013 May-Jun;37(3):346-52. doi: 10.1097/RCT.0b013e318282d935.},
   abstract = {OBJECTIVE: This study aimed to use intravoxel incoherent motion (IVIM) imaging for investigating differences between primary head and neck tumors and nodal metastases and to evaluate IVIM efficacy in predicting outcome. METHODS: Sixteen patients with head and neck cancer underwent IVIM diffusion-weighted imaging on a 1.5-T magnetic resonance imaging scanner. The significance of parametric difference between primary tumors and metastatic nodes were tested. Probabilities of progression-free survival and overall survival were estimated using the Kaplan-Meier method. RESULTS: In comparison with metastatic nodes, the primary tumors had significantly higher vascular volume fraction (f) (P < 0.0009) and lower diffusion coefficient (D) (P < 0.0002). Patients with lower SD for D had prolonged progression-free survival and overall survival (P < 0.05). CONCLUSIONS: Pretreatment IVIM measures were feasible in investigating the physiologic differences between the 2 tumor tissues. After appropriate validation, these findings might be useful in optimizing treatment planning and improving patient care.},
   keywords = {Adult
Biopsy
Data Interpretation, Statistical
Diffusion Magnetic Resonance Imaging/*methods
Echo-Planar Imaging
Female
Head and Neck Neoplasms/*pathology/therapy
Humans
Lymphatic Metastasis/*pathology
Male
Middle Aged
Retrospective Studies
Survival Analysis},
   ISSN = {1532-3145 (Electronic)
0363-8715 (Linking)},
   DOI = {10.1097/RCT.0b013e318282d935},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/23674004
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655331/pdf/nihms-435487.pdf},
   year = {2013},
   type = {Journal Article}
}

@article{RN162,
   author = {Overvliet, G. M. and Besseling, R. M. and Jansen, J. F. and van der Kruijs, S. J. and Vles, J. S. and Hofman, P. A. and Ebus, S. C. and de Louw, A. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Early onset of cortical thinning in children with rolandic epilepsy},
   journal = {Neuroimage Clin},
   volume = {2},
   pages = {434-9},
   note = {Overvliet, Geke M
Besseling, Rene M H
Jansen, Jacobus F A
van der Kruijs, Sylvie J M
Vles, Johannes S H
Hofman, Paul A M
Ebus, Saskia C M
de Louw, Anton
Aldenkamp, Albert P
Backes, Walter H
eng
Netherlands
2013/11/02 06:00
Neuroimage Clin. 2013 Mar 22;2:434-9. doi: 10.1016/j.nicl.2013.03.008. eCollection 2013.},
   abstract = {INTRODUCTION: Rolandic epilepsy, a childhood epilepsy associated with language impairments, was investigated for language-related cortical abnormalities. METHODS: Twenty-four children with rolandic epilepsy and 24 controls (age 8-14 years) were recruited and underwent the Clinical Evaluation of Language Fundamentals test. Structural MRI was performed at 3 T (voxel size 1 x 1 x 1 mm(3)) for fully automated quantitative assessment of cortical thickness. Regression analysis was used to test for differences between patients and controls and to assess the effect of age and language indices on cortical thickness. RESULTS: For patients the core language score (mean +/- SD: 92 +/- 18) was lower than for controls (106 +/- 11, p = 0.0026) and below the norm of 100 +/- 15 (p = 0.047). Patients showed specific impairments in receptive language index (87 +/- 19, p = 0.002) and language content index (87 +/- 18, p = 0.0016). Cortical thickness was reduced in patients (p < 0.05, multiple-comparisons corrected) in left perisylvian regions. Furthermore, extensive cortical thinning with age was found in predominantly left-lateralized frontal, centro-parietal and temporal regions. No associations were found between cortical thickness and language indices in the regions of aberrant cortex. CONCLUSION: The cortical abnormalities described represent subtle but significant pathomorphology in this critical phase of brain development (8-14 years) and suggest that rolandic epilepsy should not be considered merely a benign condition. Future studies employing longitudinal designs are prompted for further investigations into cerebral abnormalities in RE and associations with cognitive impairment and development.},
   keywords = {Benign rolandic epilepsy of childhood with centro-temporal spikes
Cortical thickness (quantitative)
Developmental trajectory
Language impairment},
   ISSN = {2213-1582 (Print)
2213-1582 (Linking)},
   DOI = {10.1016/j.nicl.2013.03.008},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/24179797
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777705/pdf/main.pdf},
   year = {2013},
   type = {Journal Article}
}

@article{RN163,
   author = {Overvliet, G. M. and Besseling, R. M. and van der Kruijs, S. J. and Vles, J. S. and Backes, W. H. and Hendriksen, J. G. and Ebus, S. C. and Jansen, J. F. and Hofman, P. A. and Aldenkamp, A. P.},
   title = {Clinical evaluation of language fundamentals in Rolandic epilepsy, an assessment with CELF-4},
   journal = {Eur J Paediatr Neurol},
   volume = {17},
   number = {4},
   pages = {390-6},
   note = {Overvliet, Geke M
Besseling, Rene M H
van der Kruijs, Sylvie J M
Vles, Johan S H
Backes, Walter H
Hendriksen, Jos G
Ebus, Saskia C M
Jansen, Jacobus F A
Hofman, Paul A M
Aldenkamp, Albert P
eng
England
2013/02/21 06:00
Eur J Paediatr Neurol. 2013 Jul;17(4):390-6. doi: 10.1016/j.ejpn.2013.01.001. Epub 2013 Feb 17.},
   abstract = {BACKGROUND: In clinical practice, Rolandic epilepsy is in many cases associated with developmental language impairment. However, from the literature it is unclear exactly which domains are affected; A wide variety of investigations are reported that each provide a different representation of language performance in these patients. AIMS: The aim of this study is to compare performance on the language domains between children with Rolandic epilepsy and healthy controls. METHODS: Prospective study of children with Rolandic epilepsy compared to healthy controls. 25 children (mean age 136.6 months, SD 23.0) with Rolandic epilepsy and 25 age-matched healthy controls were tested on their language function using the CELF-4 (Clinical evaluation of Language Fundamentals, Dutch edition). The healthy control were not matched regard to other important factors, particularly educational attainment and co-morbidity. Expressive language, receptive language, language content, language structure and language working memory were tested. RESULTS: In children with Rolandic epilepsy, the core language score was significant lower compared with healthy controls. They scored specifically lower on the receptive language index and language content index (both p = 0.002). A trend towards decreased expressive language index was observed (p = 0.054). Language structure and language working memory were in the normal range. CONCLUSION: Language was found to be impaired in children with typical Rolandic epilepsy. Especially semantic language processing including receptive language and language content was significantly impaired. The common denominator of these functions is semantic language processing.},
   keywords = {Adolescent
Case-Control Studies
Child
Developmental Disabilities/*diagnosis/etiology
Epilepsy, Rolandic/*complications
Female
Humans
Language Disorders/*diagnosis/*etiology
*Language Tests
Male
Sensitivity and Specificity},
   ISSN = {1532-2130 (Electronic)
1090-3798 (Linking)},
   DOI = {10.1016/j.ejpn.2013.01.001},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/23422906
https://www.ejpn-journal.com/article/S1090-3798(13)00004-4/fulltext},
   year = {2013},
   type = {Journal Article}
}

@article{RN164,
   author = {Vaessen, M. J. and Braakman, H. M. and Heerink, J. S. and Jansen, J. F. and Debeij-van Hall, M. H. and Hofman, P. A. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Abnormal modular organization of functional networks in cognitively impaired children with frontal lobe epilepsy},
   journal = {Cereb Cortex},
   volume = {23},
   number = {8},
   pages = {1997-2006},
   note = {Vaessen, M J
Braakman, H M H
Heerink, J S
Jansen, J F A
Debeij-van Hall, M H J A
Hofman, P A M
Aldenkamp, A P
Backes, W H
eng
Research Support, Non-U.S. Gov't
2012/07/10 06:00
Cereb Cortex. 2013 Aug;23(8):1997-2006. doi: 10.1093/cercor/bhs186. Epub 2012 Jul 6.},
   abstract = {Many children with frontal lobe epilepsy (FLE) have significant cognitive comorbidity, for which the underlying mechanism has not yet been unraveled, but is likely related to disturbed cerebral network integrity. Using resting-state fMRI, we investigated whether cerebral network characteristics are associated with epilepsy and cognitive comorbidity. We included 37 children with FLE and 41 healthy age-matched controls. Cognitive performance was determined by means of a computerized visual searching task. A connectivity matrix for 82 cortical and subcortical brain regions was generated for each subject by calculating the inter-regional correlation of the fMRI time signals. From the connectivity matrix, graph metrics were calculated and the anatomical configuration of aberrant connections and modular organization was investigated. Both patients and controls displayed efficiently organized networks. However, FLE patients displayed a higher modularity, implying that subnetworks are less interconnected. Impaired cognition was associated with higher modularity scores and abnormal modular organization of the brain, which was mainly expressed as a decrease in long-range and an increase in interhemispheric connectivity in patients. We showed that network modularity analysis provides a sensitive marker for cognitive impairment in FLE and suggest that abnormally interconnected functional subnetworks of the brain might underlie the cognitive problems in children with FLE.},
   keywords = {Adolescent
Brain/*physiopathology
Child
Cognition Disorders/complications/*physiopathology
Epilepsy, Frontal Lobe/complications/*physiopathology
Humans
Magnetic Resonance Imaging
Nerve Net/*physiopathology
cognitive impairment
epilepsy
functional MRI
functional reorganization
neural networks},
   ISSN = {1460-2199 (Electronic)
1047-3211 (Linking)},
   DOI = {10.1093/cercor/bhs186},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22772649
https://watermark.silverchair.com/bhs186.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAlswggJXBgkqhkiG9w0BBwagggJIMIICRAIBADCCAj0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMZNF5hrOYTxReLRGkAgEQgIICDj1Ok8X6hqT8iowa1T0xeK7gwQg_sXdYP6mNwZSQ0eHbI9X-ZZ1mZthJNiQzjFo3Ig_wr13POASats3yYZvSg61_pDV4DX3MnEAcR_JFNJDzBHX8KmFu5R34sSizJhBduJ765XLJ4SOoREdxwe0ouKnnkZAQqv9n9RHelgS0WMyyZL0g8XJ0bupndkRmj_u_8UnZYcpqWPq6Fq_yWrpXU2d3pxkYPQ1xyP-VcYJSpOAlfsTj-sERH_L1wPQ7YyCPkI1AadFCj3llNxpsVBxmL1OzuELGAPiF9-9LJm30KEsjNT4RIPlT9G_iZx8fwGCvbwcKARLNtsKuxRbbUkBfIssPqBv4-81PPSfUW-fAQYIMuVS5o3e5S0BGQGYjZHhS8NMSseHGSiVFs05VN7-iHvP87T11v6ju9EN0XIdNt1Q6F55IwFukNfcVMRSAckE5KC_7NOkjwVvO4OwCu6yT0zaLhrsRLy7PYqbTB9ew5HPUvrfrmHPVeLFII4eUBcw9z40TZ6By1eud8JE5onxs8GZtRXMhjbLLsYL4z2gLuQlojKaMZKIk_4ekTdbL1IRF4ck9lBuevuX7z1InST_C11KX2WAIkWHgDulO75p3FGNQtslf62Je41M9mrfUoQt3IDYyX3HLaUXlx7pyrm7UIdmPLdUcwJWvMGPjG0jqnHGZu-FeKzGCZV9pu4NtvGA
https://watermark.silverchair.com/bhs186.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAnUwggJxBgkqhkiG9w0BBwagggJiMIICXgIBADCCAlcGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMZRdEoY1xPp4YDihIAgEQgIICKIClrKcTlmoah62AYSQhL8uUwCWwZLeOlvzMqA7c7hU4bOmuQYZQxLmw7LSyrwb0nErniaQcWsf6I6jn8WT5EFn-0KIsmkOrXnN9VSwpnsMkcJDuD2KPBwLMSecaf7GSVg8wb_rtQ92k7XU-Mx8dLcX-JamD__fqJyWRN__OXSkNf9zDz_3TWVUCIcU0cw2augboZFVEG8RCFkxcI2ct6Grx1ftOzT8rO169RwxXef9f5kEXFKJl3En6Ln1dXttaJmZuFXZ6H9K9BceGeVp7DWAcr4G_fI-D8JL8kZmQyAQKvSS6rCoYik9KFWpUIZhBJZNe9wzgLiP08EsSFhanuXqgSuGJ6vtZi7jyKhXTYMOSBKvh38p7DLoWaNEdNvTCyghPP9vGwX8A0QgEno9EXnsCxBO7PgSwVo98d9l5c8WxGG7cJARoENmr3mDE7xS97Bl0ED7tAYknm69Qpc1j9lsprtAU2qAWVMK3EriLsYU4X3PC3lOIDLLGJj6IUlhu3OIBB3L9kYCTJIa79wTEkg-oio6ooWAyteVimx29vrtbTbfkAonCRKCnF0dcgf8a6yMSdw4sQRYmC9sDaVVDcK0wZzs0QI_UaUVceu-fkiR-50AOdmLz1jhExR4BvANIrOqotVZOF1zGWhMLfD0QP2Zfa1jz2ndK7yDHO-ekmUxQHCFvrcQevfZmV8uQqgsOLUcy_qUeu9oWFbS5niETrtb65oRcIpjjYg},
   year = {2013},
   type = {Journal Article}
}

@article{RN148,
   author = {Besseling, R. M. and Jansen, J. F. and Overvliet, G. M. and Vaessen, M. J. and Braakman, H. M. and Hofman, P. A. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Tract specific reproducibility of tractography based morphology and diffusion metrics},
   journal = {PLoS One},
   volume = {7},
   number = {4},
   pages = {e34125},
   note = {Besseling, Rene M H
Jansen, Jacobus F A
Overvliet, Geke M
Vaessen, Maarten J
Braakman, Hilde M H
Hofman, Paul A M
Aldenkamp, Albert P
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2012/04/10 06:00
PLoS One. 2012;7(4):e34125. doi: 10.1371/journal.pone.0034125. Epub 2012 Apr 2.},
   abstract = {INTRODUCTION: The reproducibility of tractography is important to determine its sensitivity to pathological abnormalities. The reproducibility of tract morphology has not yet been systematically studied and the recently developed tractography contrast Tract Density Imaging (TDI) has not yet been assessed at the tract specific level. MATERIALS AND METHODS: Diffusion tensor imaging (DTI) and probabilistic constrained spherical deconvolution (CSD) tractography are performed twice in 9 healthy subjects. Tractography is based on common space seed and target regions and performed for several major white matter tracts. Tractograms are converted to tract segmentations and inter-session reproducibility of tract morphology is assessed using Dice similarity coefficient (DSC). The coefficient of variation (COV) and intraclass correlation coefficient (ICC) are calculated of the following tract metrics: fractional anisotropy (FA), apparent diffusion coefficient (ADC), volume, and TDI. Analyses are performed both for proximal (deep white matter) and extended (including subcortical white matter) tract segmentations. RESULTS: Proximal DSC values were 0.70-0.92. DSC values were 5-10% lower in extended compared to proximal segmentations. COV/ICC values of FA, ADC, volume and TDI were 1-4%/0.65-0.94, 2-4%/0.62-0.94, 3-22%/0.53-0.96 and 8-31%/0.48-0.70, respectively, with the lower COV and higher ICC values found in the proximal segmentations. CONCLUSION: For all investigated metrics, reproducibility depended on the segmented tract. FA and ADC had relatively low COV and relatively high ICC, indicating clinical potential. Volume had higher COV but its moderate to high ICC values in most tracts still suggest subject-differentiating power. Tract TDI had high COV and relatively low ICC, which reflects unfavorable reproducibility.},
   keywords = {Adult
Anisotropy
Brain Stem/anatomy & histology
Corpus Callosum/anatomy & histology
*Diffusion Tensor Imaging
Female
Gyrus Cinguli/anatomy & histology
Humans
Male
Motor Cortex/anatomy & histology
Neural Pathways
Reproducibility of Results
Visual Pathways
Young Adult},
   ISSN = {1932-6203 (Electronic)
1932-6203 (Linking)},
   DOI = {10.1371/journal.pone.0034125},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22485157
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317780/pdf/pone.0034125.pdf},
   year = {2012},
   type = {Journal Article}
}

@article{RN149,
   author = {Braakman, H. M. and van der Kruijs, S. J. and Vaessen, M. J. and Jansen, J. F. and Debeij-van Hall, M. H. and Vles, J. S. and Aldenkamp, A. P. and Backes, W. H. and Hofman, P. A.},
   title = {Microstructural and functional MRI studies of cognitive impairment in epilepsy},
   journal = {Epilepsia},
   volume = {53},
   number = {10},
   pages = {1690-9},
   note = {Braakman, Hilde M H
van der Kruijs, Sylvie J M
Vaessen, Maarten J
Jansen, Jacobus F A
Debeij-van Hall, Mariette H J A
Vles, Johan S H
Aldenkamp, Albert P
Backes, Walter H
Hofman, Paul A M
eng
Review
2012/08/15 06:00
Epilepsia. 2012 Oct;53(10):1690-9. doi: 10.1111/j.1528-1167.2012.03624.x. Epub 2012 Aug 13.},
   abstract = {Cognitive impairment is the most common comorbidity in children with epilepsy, but its pathophysiology and predisposing conditions remain unknown. Clinical epilepsy characteristics are not conclusive in determining cognitive outcome. Because many children with epilepsy do not have macrostructural magnetic resonance imaging (MRI) abnormalities, the underlying substrate for cognitive impairment may be found at the microstructural or functional level. In the last two decades, new MRI techniques have been developed that have the potential to visualize microstructural or functional abnormalities associated with cognitive impairment. These include volumetric MRI, voxel-based morphometry (VBM), diffusion tensor imaging (DTI), MR spectroscopy (MRS), and functional MRI (fMRI). All of these techniques have shed new light on various aspects associated with, or underlying, cognitive impairment, although their use in epilepsy has been limited and focused mostly on adults. Therefore, in this review, the use of all these different MRI techniques to unravel cognitive impairment in epilepsy is discussed both in adults and children with epilepsy. Volumetric MRI and VBM have revealed significant volume losses in the area of the seizure focus as well as in distant areas. DTI adds evidence of loss of integrity of connections from the seizure focus to distant areas as well as between distant areas. MRS and fMRI have shown impaired function both in the area of the seizure focus as well as in distant structures. For this review we have compiled and compared findings from the various techniques to conclude that cognitive impairment in epilepsy results from a network disorder in which the (micro)structures as well as the functionality can be disturbed.},
   keywords = {Brain/*blood supply/pathology
Cognition Disorders/*etiology/*pathology
Epilepsy/*complications
Humans
Image Processing, Computer-Assisted
*Magnetic Resonance Imaging
Oxygen/blood
PubMed/statistics & numerical data},
   ISSN = {1528-1167 (Electronic)
0013-9580 (Linking)},
   DOI = {10.1111/j.1528-1167.2012.03624.x},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22889330
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2012.03624.x},
   year = {2012},
   type = {Journal Article}
}

@article{RN150,
   author = {Jansen, J. F. and Carlson, D. L. and Lu, Y. and Stambuk, H. E. and Moreira, A. L. and Singh, B. and Patel, S. G. and Kraus, D. H. and Wong, R. J. and Shaha, A. R. and Shah, J. P. and Shukla-Dave, A.},
   title = {Correlation of a priori DCE-MRI and (1)H-MRS data with molecular markers in neck nodal metastases: Initial analysis},
   journal = {Oral Oncol},
   volume = {48},
   number = {8},
   pages = {717-22},
   note = {Jansen, Jacobus F A
Carlson, Diane L
Lu, Yonggang
Stambuk, Hilda E
Moreira, Andre L
Singh, Bhuvanesh
Patel, Snehal G
Kraus, Dennis H
Wong, Richard J
Shaha, Ashok R
Shah, Jatin P
Shukla-Dave, Amita
eng
R01 CA115895/CA/NCI NIH HHS/
R01 CA115895-05/CA/NCI NIH HHS/
1 R01 CA115895/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
England
2012/03/01 06:00
Oral Oncol. 2012 Aug;48(8):717-22. doi: 10.1016/j.oraloncology.2012.02.001. Epub 2012 Feb 25.},
   abstract = {The aim of the present study is to correlate non-invasive, pretreatment biological imaging (dynamic contrast enhanced-MRI [DCE-MRI] and proton magnetic resonance spectroscopy [(1)H-MRS]) findings with specific molecular marker data in neck nodal metastases of head and neck squamous cell carcinoma (HNSCC) patients. Pretreatment DCE-MRI and (1)H-MRS were performed on neck nodal metastases of 12 patients who underwent surgery. Surgical specimens were analyzed with immunohistochemistry (IHC) assays for: Ki-67 (reflecting cellular proliferation), vascular endothelial growth factor (VEGF) (the "endogenous marker" of tumor vessel growth), carbonic anhydrase (CAIX), hypoxia inducible transcription factor (HIF-1alpha), and human papillomavirus (HPV). Additionally, necrosis was estimated based on H&E staining. The Spearman correlation was used to compare DCE-MRI, (1)H-MRS, and molecular marker data. A significant correlation was observed between DCE-MRI parameter std(k(ep)) and VEGF IHC expression level (rho=0.81, p=0.0001). Furthermore, IHC expression levels of Ki-67 inversely correlated with std(K(trans)) and std(v(e)) (rho=-0.71; p=0.004, and rho=-0.73; p=0.003, respectively). Other DCE-MRI, (1)H-MRS and IHC values did not show significant correlation. The results of this preliminary study indicate that the level of heterogeneity of perfusion in metastatic HNSCC seems positively correlated with angiogenesis, and inversely correlated with proliferation. These results are preliminary in nature and are indicative, and not definitive, trends portrayed in HNSCC patients with nodal disease. Future studies with larger patient populations need to be carried out to validate and clarify our preliminary findings.},
   keywords = {Adult
Aged
Biomarkers, Tumor/metabolism
Carbonic Anhydrases/metabolism
Carcinoma, Squamous Cell/*diagnosis/metabolism/secondary
Contrast Media
Female
Human papillomavirus 16/metabolism
Humans
Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
Ki-67 Antigen/metabolism
Lymph Nodes/*pathology
Lymphatic Metastasis
Magnetic Resonance Imaging/*methods
Magnetic Resonance Spectroscopy/*methods
Male
Middle Aged
Mouth Neoplasms/*diagnosis/metabolism/pathology
Neck
Vascular Endothelial Growth Factor A/metabolism},
   ISSN = {1879-0593 (Electronic)
1368-8375 (Linking)},
   DOI = {10.1016/j.oraloncology.2012.02.001},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22366441
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368067/pdf/nihms355666.pdf},
   year = {2012},
   type = {Journal Article}
}

@article{RN151,
   author = {Jansen, J. F. and Schoder, H. and Lee, N. Y. and Stambuk, H. E. and Wang, Y. and Fury, M. G. and Patel, S. G. and Pfister, D. G. and Shah, J. P. and Koutcher, J. A. and Shukla-Dave, A.},
   title = {Tumor metabolism and perfusion in head and neck squamous cell carcinoma: pretreatment multimodality imaging with 1H magnetic resonance spectroscopy, dynamic contrast-enhanced MRI, and [18F]FDG-PET},
   journal = {Int J Radiat Oncol Biol Phys},
   volume = {82},
   number = {1},
   pages = {299-307},
   note = {Jansen, Jacobus F A
Schoder, Heiko
Lee, Nancy Y
Stambuk, Hilda E
Wang, Ya
Fury, Matthew G
Patel, Snehal G
Pfister, David G
Shah, Jatin P
Koutcher, Jason A
Shukla-Dave, Amita
eng
R01 CA115895/CA/NCI NIH HHS/
R01 CA115895-05/CA/NCI NIH HHS/
1R01CA-115895/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
2011/01/18 06:00
Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):299-307. doi: 10.1016/j.ijrobp.2010.11.022. Epub 2011 Jan 13.},
   abstract = {PURPOSE: To correlate proton magnetic resonance spectroscopy ((1)H-MRS), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and (18)F-labeled fluorodeoxyglucose positron emission tomography ([(18)F]FDG PET) of nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) for assessment of tumor biology. Additionally, pretreatment multimodality imaging was evaluated for its efficacy in predicting short-term response to treatment. METHODS AND MATERIALS: Metastatic neck nodes were imaged with (1)H-MRS, DCE-MRI, and [(18)F]FDG PET in 16 patients with newly diagnosed HNSCC, before treatment. Short-term patient radiological response was evaluated at 3 to 4 months. Correlations among (1)H-MRS (choline concentration relative to water [Cho/W]), DCE-MRI (volume transfer constant [K(trans)]; volume fraction of the extravascular extracellular space [v(e)]; and redistribution rate constant [k(ep)]), and [(18)F]FDG PET (standard uptake value [SUV] and total lesion glycolysis [TLG]) were calculated using nonparametric Spearman rank correlation. To predict short-term responses, logistic regression analysis was performed. RESULTS: A significant positive correlation was found between Cho/W and TLG (rho = 0.599; p = 0.031). Cho/W correlated negatively with heterogeneity measures of standard deviation std(v(e)) (rho = -0.691; p = 0.004) and std(k(ep)) (rho = -0.704; p = 0.003). Maximum SUV (SUVmax) values correlated strongly with MRI tumor volume (rho = 0.643; p = 0.007). Logistic regression indicated that std(K(trans)) and SUVmean were significant predictors of short-term response (p < 0.07). CONCLUSION: Pretreatment multimodality imaging using (1)H-MRS, DCE-MRI, and [(18)F]FDG PET is feasible in HNSCC patients with nodal metastases. Additionally, combined DCE-MRI and [(18)F]FDG PET parameters were predictive of short-term response to treatment.},
   keywords = {Adult
Aged
Antibodies, Monoclonal, Humanized/therapeutic use
Antineoplastic Agents/therapeutic use
Bevacizumab
Carcinoma, Squamous Cell/*metabolism/secondary/therapy
Chemoradiotherapy/methods
Choline/metabolism
Cisplatin/therapeutic use
Contrast Media
Diagnostic Imaging/*methods
Extracellular Space/metabolism
Feasibility Studies
Female
Fluorodeoxyglucose F18/pharmacokinetics
Fluorouracil/therapeutic use
Gadolinium DTPA
Glucose/metabolism
Glycolysis
Head and Neck Neoplasms/*metabolism/pathology/therapy
Humans
Lymphatic Metastasis
Magnetic Resonance Imaging/methods
Magnetic Resonance Spectroscopy/methods
Male
Middle Aged
Nasopharyngeal Neoplasms/metabolism/pathology/therapy
Positron-Emission Tomography/methods
Prospective Studies
Radiopharmaceuticals/pharmacokinetics
Regression Analysis
Statistics, Nonparametric
Tongue Neoplasms/metabolism/pathology/therapy
Tonsillar Neoplasms/metabolism/pathology/therapy},
   ISSN = {1879-355X (Electronic)
0360-3016 (Linking)},
   DOI = {10.1016/j.ijrobp.2010.11.022},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/21236594
https://www.redjournal.org/article/S0360-3016(10)03570-4/pdf},
   year = {2012},
   type = {Journal Article}
}

@article{RN152,
   author = {Lu, Y. and Jansen, J. F. and Mazaheri, Y. and Stambuk, H. E. and Koutcher, J. A. and Shukla-Dave, A.},
   title = {Extension of the intravoxel incoherent motion model to non-gaussian diffusion in head and neck cancer},
   journal = {J Magn Reson Imaging},
   volume = {36},
   number = {5},
   pages = {1088-96},
   note = {Lu, Yonggang
Jansen, Jacobus F A
Mazaheri, Yousef
Stambuk, Hilda E
Koutcher, Jason A
Shukla-Dave, Amita
eng
R01 CA115895/CA/NCI NIH HHS/
1 R01 CA115895/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
2012/07/25 06:00
J Magn Reson Imaging. 2012 Nov;36(5):1088-96. doi: 10.1002/jmri.23770. Epub 2012 Jul 23.},
   abstract = {PURPOSE: To extend the intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) model to restricted diffusion and to simultaneously quantify the perfusion and restricted diffusion parameters in neck nodal metastases. MATERIALS AND METHODS: The non-gaussian (NG)-IVIM model was developed and tested on diffusion-weighted MRI data collected on a 1.5-Tesla MRI scanner from eight patients with head and neck cancer. Voxel-wise parameter quantification was performed by using a noise-rectified least-square fitting method. The NG-IVIM, IVIM, Kurtosis, and ADC (apparent diffusion coefficient) models were used for comparison. For each voxel, within the metastatic node, the optimal model was determined using the Bayesian Information Criterion. The voxel percentage preferred by each model was calculated and the optimal model map was generated. Monte Carlo simulations were performed to evaluate the accuracy and precision dependency of the new model. RESULTS: For the eight neck nodes, the range of voxel percentage preferred by the NG-IVIM model was 2.3-79.3%. The optimal modal maps showed heterogeneities within the tumors. The Monte Carlo simulations demonstrated that the accuracy and precision of the NG-IVIM model improved by increasing signal-to-noise ratio and b value. CONCLUSION: The NG-IVIM model characterizes perfusion and restricted diffusion simultaneously in neck nodal metastases.},
   keywords = {*Algorithms
Computer Simulation
Data Interpretation, Statistical
Female
Head and Neck Neoplasms/*pathology/*secondary
Humans
Imaging, Three-Dimensional/*methods
Least-Squares Analysis
Lymph Nodes/*pathology
Lymphatic Metastasis
Male
Middle Aged
*Models, Biological
Models, Statistical
Motion
Normal Distribution
Pattern Recognition, Automated/*methods
Reproducibility of Results
Sensitivity and Specificity},
   ISSN = {1522-2586 (Electronic)
1053-1807 (Linking)},
   DOI = {10.1002/jmri.23770},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22826198
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482143/pdf/nihms-391133.pdf},
   year = {2012},
   type = {Journal Article}
}

@article{RN153,
   author = {Shukla-Dave, A. and Lee, N. Y. and Jansen, J. F. and Thaler, H. T. and Stambuk, H. E. and Fury, M. G. and Patel, S. G. and Moreira, A. L. and Sherman, E. and Karimi, S. and Wang, Y. and Kraus, D. and Shah, J. P. and Pfister, D. G. and Koutcher, J. A.},
   title = {Dynamic contrast-enhanced magnetic resonance imaging as a predictor of outcome in head-and-neck squamous cell carcinoma patients with nodal metastases},
   journal = {Int J Radiat Oncol Biol Phys},
   volume = {82},
   number = {5},
   pages = {1837-44},
   note = {Shukla-Dave, Amita
Lee, Nancy Y
Jansen, Jacobus F A
Thaler, Howard T
Stambuk, Hilda E
Fury, Matthew G
Patel, Snehal G
Moreira, Andre L
Sherman, Eric
Karimi, Sasan
Wang, Ya
Kraus, Dennis
Shah, Jatin P
Pfister, David G
Koutcher, Jason A
eng
R01 CA115895/CA/NCI NIH HHS/
R01 CA115895-05/CA/NCI NIH HHS/
1 R01 CA115895/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
2011/05/24 06:00
Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1837-44. doi: 10.1016/j.ijrobp.2011.03.006. Epub 2011 May 19.},
   abstract = {PURPOSE: Dynamic contrast-enhanced MRI (DCE-MRI) can provide information regarding tumor perfusion and permeability and has shown prognostic value in certain tumors types. The goal of this study was to assess the prognostic value of pretreatment DCE-MRI in head and neck squamous cell carcinoma (HNSCC) patients with nodal disease undergoing chemoradiation therapy or surgery. METHODS AND MATERIALS: Seventy-four patients with histologically proven squamous cell carcinoma and neck nodal metastases were eligible for the study. Pretreatment DCE-MRI was performed on a 1.5T MRI. Clinical follow-up was a minimum of 12 months. DCE-MRI data were analyzed using the Tofts model. DCE-MRI parameters were related to treatment outcome (progression-free survival [PFS] and overall survival [OS]). Patients were grouped as no evidence of disease (NED), alive with disease (AWD), dead with disease (DOD), or dead of other causes (DOC). Prognostic significance was assessed using the log-rank test for single variables and Cox proportional hazards regression for combinations of variables. RESULTS: At last clinical follow-up, for Stage III, all 12 patients were NED. For Stage IV, 43 patients were NED, 4 were AWD, 11 were DOD, and 4 were DOC. K(trans) is volume transfer constant. In a stepwise Cox regression, skewness of K(trans) (volume transfer constant) was the strongest predictor for Stage IV patients (PFS and OS: p <0.001). CONCLUSION: Our study shows that skewness of K(trans) was the strongest predictor of PFS and OS in Stage IV HNSCC patients with nodal disease. This study suggests an important role for pretreatment DCE-MRI parameter K(trans) as a predictor of outcome in these patients.},
   keywords = {Adult
Aged
Aged, 80 and over
Analysis of Variance
Carcinoma, Squamous Cell/*diagnosis/mortality/pathology/secondary/therapy
Chemoradiotherapy/methods
*Contrast Media
Disease-Free Survival
Female
Follow-Up Studies
Gadolinium DTPA
Humans
Lymphatic Metastasis
Magnetic Resonance Imaging/*methods
Male
Middle Aged
Mouth Neoplasms/*diagnosis/mortality/pathology/secondary/therapy
Neoplasm Staging
Oropharyngeal Neoplasms/*diagnosis/mortality/pathology/secondary/therapy
Proportional Hazards Models
Retrospective Studies
Statistics, Nonparametric
Treatment Outcome},
   ISSN = {1879-355X (Electronic)
0360-3016 (Linking)},
   DOI = {10.1016/j.ijrobp.2011.03.006},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/21601373
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177034/pdf/nihms299438.pdf},
   year = {2012},
   type = {Journal Article}
}

@article{RN154,
   author = {Vaessen, M. J. and Jansen, J. F. and Vlooswijk, M. C. and Hofman, P. A. and Majoie, H. J. and Aldenkamp, A. P. and Backes, W. H.},
   title = {White matter network abnormalities are associated with cognitive decline in chronic epilepsy},
   journal = {Cereb Cortex},
   volume = {22},
   number = {9},
   pages = {2139-47},
   note = {Vaessen, Maarten J
Jansen, Jacobus F A
Vlooswijk, Marielle C G
Hofman, Paul A M
Majoie, H J Marian
Aldenkamp, Albert P
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2011/11/01 06:00
Cereb Cortex. 2012 Sep;22(9):2139-47. doi: 10.1093/cercor/bhr298. Epub 2011 Oct 29.},
   abstract = {Patients with chronic epilepsy frequently display cognitive comorbidity and might have widespread network abnormalities outside the epileptic zone, which might affect a variety of cognitive functions and global intelligence. We aimed to study the role of white matter connectivity in cognitive comorbidity. Thirty-nine patients with nonsymptomatic localization-related epilepsy and varying degrees of cognitive impairment and 23 age-matched healthy controls were included. Whole brain white matter networks were constructed from fiber tractography. Weighted graph theoretical analysis was performed to study white matter network abnormalities associated with epilepsy and cognition. Patients with severe cognitive impairment showed lower clustering (a measure of brain network segregation) and higher path length (a measure of brain network integration) compared with the healthy controls and patients with little or no cognitive impairment, whereas whole brain white matter volume did not differ. Correlation analyses revealed that IQ and cognitive impairment were strongly associated with clustering and path lengths. This study revealed impaired white matter connectivity, associated with cognitive comorbidity in patients with chronic epilepsy. As whole brain white matter volumes were preserved in the patient group, our results suggest an important role for the network topology rather than volumetric changes, in epilepsy with cognitive decline.},
   keywords = {Adult
Brain/*pathology
Chronic Disease
Cognition Disorders/etiology/*pathology
Diffusion Tensor Imaging
Epilepsy/complications/*pathology
Female
Humans
Image Interpretation, Computer-Assisted
Male
Nerve Fibers, Myelinated/*pathology
Neural Pathways/*pathology},
   ISSN = {1460-2199 (Electronic)
1047-3211 (Linking)},
   DOI = {10.1093/cercor/bhr298},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22038907
https://watermark.silverchair.com/bhr298.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAlwwggJYBgkqhkiG9w0BBwagggJJMIICRQIBADCCAj4GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMCMc7lWaMuj4xQ5dkAgEQgIICD9dYGRvRXcRUtt4EfLvZlNevDPXDevemo8wh1NN8WIBhTpmeqlAAXqqyH8aqC8OVKKBgUll2A9GuyhIEuS2wE2meG4OIiJPMRAEcUooPuMqvmN3OAaebrK63zUp1BJmyqOImCn_p0nUn-YEqykFh0YZWNlCJBo2BCaL2BESIbIrLftPjhK-IuJWUvIfTeiW8gIidGMe3ob2Myh8jNpLrCLhiZZttkAtx0EpcR1k8qLFQpVonvEH1ORWJZq_Ajv_K48GUWF2_HcL2bxhipcTVehZPcfG7tCzbAUCCPK-39LAkdtpzCtRkwe9jwXkusbZwcZ8HTYw0INDNQZ5d5Oe5S-gCDL_BNyq4ERIewfqATI1NRPnV7apHvKo6Ak8tKIpSwrtj04Tbw-3ykMgjIFFiiXpU-UIPzEYkCnccPiO1k9B-XF9xNvqxFkk3uTxCVVufFlbN6xlaaOiPSlPfW7Qyq_gDr8uAfLDcenZHVoWpKGePz2gYz1clln3cLipzUQ4qR3kTx_QAnMzqUb2RB1SxnqZpKsIZgXZq6jurv9qza6oy_5CPavU_HZfwWxg8J1HNeJjX1OILWMF7ozbKSvYTyPDwPzw0Mlpe9dOnU9AsJ1_JhOcd95i66NcS-RXRS77JmRwwS_FxBy58g2SN8LpTfh0Rax-GlAmnsFgsoF40OGG28amFrQIGxWecOYl1KHgM
https://watermark.silverchair.com/bhr298.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAnUwggJxBgkqhkiG9w0BBwagggJiMIICXgIBADCCAlcGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMhfNx6pYQtWD1-LJMAgEQgIICKIjZqy7iVZKyHy0dnTtDg4EBSiFX46g7Vcc5ceaTKWvEg1DcwOIakbWRNBn76vyWERKTPGAa2Y8Qi3npY8W57Fh9xyjIRxl8QEVpw9vLiowQ7byVq8N4unqzgyFghHo4X-JHrSUBwpyMIJ2l9pnIdn3WmjZIFLQH5vowUKaYeZpD4xTqtan7-SVdLvZTh4S23E4Ds6HDXPoO_TZQaErNE1eXmbCWFah0t_QgV2esE-DDzcGrdluUb5OX_s7MExEU9_EPv5JL5pgxfKPTuk5zxyE9l-qausVZ4s8IyIbcSkywPoTsvx9vgPhO-idSACyJt8dV0aNj2TW2iUyRp6vON6rSH4hqaTcE_jENS8xh_zuELyj89UUC4WE7I5YKVUR8blz86KuBCU5pOfTa9Ep3D_0q8bnbQnkhrNVlt0uV8Dea9jeOZ75bE3mJXnA6iaJEqGMDz05AYoUYLmSYQgwOHIG7sAUgP3fgL90P39xGFB47Ewayx2VotdSZIJa8WzQLrp0t-fUOwYD9eAvd4WAKkrRpf7Gu4Qlqvcz6bW_I8t-B1m1D07n9kKVNKnKAMdqTr2EwZN-7u0LpfsArsrrDA-ge5To7URgbCeFKcvJN66IjT5iECgmltxAMl6WAGUVsB2iKcYJjbkEp5HpsjlKUQKfnWsRPUhc8rQ5nSImBMBlMcnzXhgXWjRItj6C2l-WkSvBNzRBX-yFAPsLPJITnwoI99JorE3OYzA},
   year = {2012},
   type = {Journal Article}
}

@article{RN155,
   author = {van der Kruijs, S. J. and Bodde, N. M. and Vaessen, M. J. and Lazeron, R. H. and Vonck, K. and Boon, P. and Hofman, P. A. and Backes, W. H. and Aldenkamp, A. P. and Jansen, J. F.},
   title = {Functional connectivity of dissociation in patients with psychogenic non-epileptic seizures},
   journal = {J Neurol Neurosurg Psychiatry},
   volume = {83},
   number = {3},
   pages = {239-47},
   note = {van der Kruijs, Sylvie J M
Bodde, Nynke M G
Vaessen, Maarten J
Lazeron, Richard H C
Vonck, Kristl
Boon, Paul
Hofman, Paul A M
Backes, Walter H
Aldenkamp, Albert P
Jansen, Jacobus F A
eng
Research Support, Non-U.S. Gov't
England
2011/11/08 06:00
J Neurol Neurosurg Psychiatry. 2012 Mar;83(3):239-47. doi: 10.1136/jnnp-2011-300776. Epub 2011 Nov 5.},
   abstract = {INTRODUCTION: Psychogenic non-epileptic seizures (PNES) resemble epileptic seizures, but lack epileptiform brain activity. Instead, the cause is assumed to be psychogenic. An abnormal coping strategy may be exhibited by PNES patients, as indicated by their increased tendency to dissociate. Investigation of resting-state networks may reveal altered routes of information and emotion processing in PNES patients. The authors therefore investigated whether PNES patients differ from healthy controls in their resting-state functional connectivity characteristics and whether these connections are associated with the tendency to dissociate. METHODS: 11 PNES patients without psychiatric comorbidity and 12 healthy controls underwent task-related paradigms (picture-encoding and Stroop paradigms) and resting-state functional MRI (rsfMRI). Global cognitive performance was tested using the Raven's Matrices test and participants completed questionnaires for evaluating dissociation. Functional connectivity analysis on rsfMRI was based on seed regions extracted from task-related fMRI activation maps. RESULTS: The patients displayed a significantly lower cognitive performance and significantly higher dissociation scores. No significant differences were found between the picture-encoding and Stroop colour-naming activation maps between controls and patients with PNES. However, functional connectivity maps from the rsfMRI were statistically different. For PNES patients, stronger connectivity values between areas involved in emotion (insula), executive control (inferior frontal gyrus and parietal cortex) and movement (precentral sulcus) were observed, which were significantly associated with dissociation scores. CONCLUSION: The abnormal, strong functional connectivity in PNES patients provides a neurophysiological correlate for the underlying psychoform and somatoform dissociation mechanism where emotion can influence executive control, resulting in altered motor function (eg, seizure-like episodes).},
   keywords = {Adolescent
Adult
Brain/physiopathology
Case-Control Studies
Dissociative Disorders/*physiopathology
Electroencephalography
Emotions/physiology
Executive Function/physiology
Female
Functional Neuroimaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways/physiopathology
Neuropsychological Tests
Psychophysiologic Disorders/*physiopathology
Seizures/etiology/*physiopathology
Stroop Test
Young Adult},
   ISSN = {1468-330X (Electronic)
0022-3050 (Linking)},
   DOI = {10.1136/jnnp-2011-300776},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22056967
https://jnnp.bmj.com/content/83/3/239.long},
   year = {2012},
   type = {Journal Article}
}

@article{RN145,
   author = {Overvliet, G. M. and Aldenkamp, A. P. and Klinkenberg, S. and Nicolai, J. and Vles, J. S. and Besseling, R. M. and Backes, W. and Jansen, J. F. and Hofman, P. A. and Hendriksen, J.},
   title = {Correlation between language impairment and problems in motor development in children with rolandic epilepsy},
   journal = {Epilepsy Behav},
   volume = {22},
   number = {3},
   pages = {527-31},
   note = {Overvliet, Geke M
Aldenkamp, Albert P
Klinkenberg, Sylvia
Nicolai, Joost
Vles, Johan S H
Besseling, Rene M H
Backes, Walter
Jansen, Jacobus F A
Hofman, Paul A
Hendriksen, Jos
eng
2011/09/23 06:00
Epilepsy Behav. 2011 Nov;22(3):527-31. doi: 10.1016/j.yebeh.2011.08.012. Epub 2011 Sep 21.},
   abstract = {OBJECTIVE: An association between impaired school performance and rolandic epilepsy is frequently reported. Language outcome, in particular, seems to be affected, although rolandic epilepsy originates from the motor-sensory cortex. In this study we tried to find a correlation between locomotion problems and language impairment. METHODS: In this noncontrolled, open, clinical cohort study of 48 children with rolandic epilepsy, a 24-hour EEG and a neuropsychological assessment were obtained for all children. RESULTS: Children with rolandic epilepsy had a significant delay in reading skills (reading words: mean=6 months, SD=11.9, P<0.002; reading sentences: mean=8.6 months, SD=12.7, P<0.001), compared with the healthy population. There was a significant correlation between problems in motor development and delays in reading skills (reading words: r=-0.426, P=0.006; reading sentences: r=-0.343, P=0.03). CONCLUSION: Reading performance is impaired in children with rolandic epilepsy. Reading of sentences is more impaired than reading of words. There is a significant correlation between problems in motor development and language, suggesting their interaction at the level of the cortex.},
   keywords = {Achievement
Child
Electroencephalography
Epilepsy, Rolandic/*complications
Female
Gait Disorders, Neurologic/*complications/*etiology
Humans
Language Development Disorders/*complications/*etiology
Male
Neuropsychological Tests
Psychiatric Status Rating Scales
Reading
Retrospective Studies
*Statistics as Topic
Statistics, Nonparametric},
   ISSN = {1525-5069 (Electronic)
1525-5050 (Linking)},
   DOI = {10.1016/j.yebeh.2011.08.012},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/21937281
https://www.epilepsybehavior.com/article/S1525-5050(11)00476-8/fulltext
https://www.epilepsybehavior.com/article/S1525-5050(11)00476-8/pdf},
   year = {2011},
   type = {Journal Article}
}

@article{RN146,
   author = {Vlooswijk, M. C. and Jansen, J. F. and Jeukens, C. R. and Majoie, H. J. and Hofman, P. A. and de Krom, M. C. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Memory processes and prefrontal network dysfunction in cryptogenic epilepsy},
   journal = {Epilepsia},
   volume = {52},
   number = {8},
   pages = {1467-75},
   note = {Vlooswijk, Marielle C G
Jansen, Jacobus F A
Jeukens, Cecile R L P N
Majoie, H J Marian
Hofman, Paul A M
de Krom, Marc C T F M
Aldenkamp, Albert P
Backes, Walter H
eng
Comparative Study
Research Support, Non-U.S. Gov't
2011/06/04 06:00
Epilepsia. 2011 Aug;52(8):1467-75. doi: 10.1111/j.1528-1167.2011.03108.x. Epub 2011 Jun 2.},
   abstract = {PURPOSE: Impaired memory performance is the most frequently reported cognitive problem in patients with chronic epilepsy. To examine memory deficits many studies have focused on the role of the mesiotemporal lobe, mostly with hippocampal abnormalities. However, the role of the prefrontal brain remains unresolved. To investigate the neuronal correlates of working memory dysfunction in patients without structural lesions, a combined study of neurocognitive assessment, hippocampal and cerebral volumetry, and functional magnetic resonance imaging of temporal and frontal memory networks was performed. METHODS: Thirty-six patients with cryptogenic localization-related epilepsy and 21 healthy controls underwent neuropsychological assessment of intelligence (IQ) and memory. On T(1) -weighted images obtained by 3-Tesla magnetic resonance imaging (MRI), volumetry of the hippocampi and the cerebrum was performed. Functional MRI (fMRI) was performed with a novel picture encoding and Sternberg paradigm that activated different memory-mediating brain regions. Functional connectivity analysis comprised cross-correlation of signal time-series of the most strongly activated regions involved in working memory function. KEY FINDINGS: Patients with epilepsy displayed lower IQ values; impaired transient aspects of information processing, as indicated by lower scores on the digit-symbol substitution test (DSST); and decreased short-term memory performance relative to healthy controls, as measured with the Wechsler Adult Intelligence Scale subtests for working memory, and word and figure recognition. This could not be related to any hippocampal volume changes. No group differences were found regarding volumetry or fMRI-derived functional activation. In the Sternberg paradigm, a network involving the anterior cingulate and the middle and inferior frontal gyrus was activated. A reduced strength of four connections in this prefrontal network was associated with the DSST and word recognition performance in the patient group. SIGNIFICANCE: Deficits in the processes involved in transient working memory, and to a lesser extent in short-term memory, in patients with localization-related epilepsy of both temporal and extratemporal origin cannot be attributed to hippocampal atrophy or function only, but are also related to reduced functional connectivity in the prefrontal brain. Because patients with symptomatic lesions or mesiotemporal sclerosis were excluded from this study, the results cannot be explained by structural lesions. Therefore, the current findings highlight the influence of epilepsy on the prefrontal network integrity as a possible underlying problem of memory impairment.},
   keywords = {Adult
Brain/pathology
Case-Control Studies
Cognition Disorders/*physiopathology
Epilepsy/pathology/*physiopathology
Female
Hippocampus/pathology/physiopathology
Humans
Intelligence
Magnetic Resonance Imaging
Male
*Memory
Nerve Net
Organ Size
Prefrontal Cortex/pathology/*physiopathology},
   ISSN = {1528-1167 (Electronic)
0013-9580 (Linking)},
   DOI = {10.1111/j.1528-1167.2011.03108.x},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/21635235
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2011.03108.x},
   year = {2011},
   type = {Journal Article}
}

@article{RN147,
   author = {Vlooswijk, M. C. and Vaessen, M. J. and Jansen, J. F. and de Krom, M. C. and Majoie, H. J. and Hofman, P. A. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Loss of network efficiency associated with cognitive decline in chronic epilepsy},
   journal = {Neurology},
   volume = {77},
   number = {10},
   pages = {938-44},
   note = {Vlooswijk, M C G
Vaessen, M J
Jansen, J F A
de Krom, M C F T M
Majoie, H J M
Hofman, P A M
Aldenkamp, A P
Backes, W H
eng
Comparative Study
Research Support, Non-U.S. Gov't
2011/08/13 06:00
Neurology. 2011 Sep 6;77(10):938-44. doi: 10.1212/WNL.0b013e31822cfc2f. Epub 2011 Aug 10.},
   abstract = {OBJECTIVE: To study the relation between possibly altered whole brain topology and intellectual decline in chronic epilepsy, a combined study of neurocognitive assessment and graph theoretical network analysis of fMRI was performed. METHODS: Forty-one adult patients with cryptogenic localization-related epilepsy and 23 healthy controls underwent an intelligence test and fMRI with a silent-word generation paradigm. A set of undirected graphs was constructed by cross-correlating the signal time series of 893 cortical and subcortical regions. Possible changes in cerebral network efficiency were assessed by performing graph theoretical network analysis. RESULTS: Healthy subjects displayed efficient small world properties, characterized by high clustering and short path lengths. On the contrary, in patients with epilepsy a disruption of both local segregation and global integration was found. An association of more pronounced intellectual decline with more disturbed local segregation was observed in the patient group. The effect of antiepileptic drug use on cognitive decline was mediated by decreased clustering. CONCLUSIONS: These findings support the hypothesis that chronic localization-related epilepsy causes cognitive deficits by inducing global cerebral network changes instead of a localized disruption only. Whether this is the result of epilepsy per se or the use of antiepileptic drugs remains to be elucidated. For application in clinical practice, future studies should address the relevance of altered cerebral network topology in prediction of cognitive deficits and monitoring of therapeutic interventions.},
   keywords = {Adolescent
Adult
Anticonvulsants/adverse effects/therapeutic use
Chronic Disease
Cognition Disorders/chemically induced/*physiopathology/*psychology
Epilepsies, Partial/drug therapy/*physiopathology/*psychology
Female
Humans
*Intelligence Tests
Magnetic Resonance Imaging/methods
Male
Middle Aged
Nerve Net/drug effects/*physiopathology
Young Adult},
   ISSN = {1526-632X (Electronic)
0028-3878 (Linking)},
   DOI = {10.1212/WNL.0b013e31822cfc2f},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/21832213
https://n.neurology.org/content/77/10/938.long},
   year = {2011},
   type = {Journal Article}
}

@article{RN137,
   author = {Colon, A. J. and Hofman, P. and Ossenblok, P. P. and Jansen, J. F. and Ter Beek, L. C. and Berting, R. and Stam, C. J. and Boon, P.},
   title = {MRS-lateralisation index in patients with epilepsy and focal cortical dysplasia or a MEG-focus using bilateral single voxels},
   journal = {Epilepsy Res},
   volume = {89},
   number = {1},
   pages = {148-53},
   note = {Colon, A J
Hofman, P
Ossenblok, P P W
Jansen, J F A
Ter Beek, L C
Berting, R
Stam, C J
Boon, P
eng
Research Support, Non-U.S. Gov't
Netherlands
2009/12/22 06:00
Epilepsy Res. 2010 Mar;89(1):148-53. doi: 10.1016/j.eplepsyres.2009.11.007. Epub 2009 Dec 21.},
   abstract = {PURPOSE: To evaluate if single voxel proton magnetic resonance spectroscopy (SV-MRS) can help in lateralising and sometimes in localizing an epileptogenic focus. The assumption is that in MRI negative patients the underlying pathology most often is focal cortical dysplasia (FCD). Several studies have shown that in the presence of FCD there are also (1)H-MRS abnormalities on the contralateral side. However, in most cases the studied group was not homogeneous and included different forms of dysplasias, including band heterotopias and polymicrogyria, and the studies used different spectroscopy protocols. In the present study, using bilateral SV-MRS we investigated the presence of a lateralisation index in two groups of patients with localisation related epilepsy: patients with focal cortical dysplasia on MRI and patients without MRI abnormalities with a focus identified by MEG. Aim of the study was to show that in both groups the expected epileptogenic side shows more pronounced metabolic alterations, making MRS a possible screening tool for clarifying lateralisation questions in patients with cryptogenic localisation related epilepsy. METHODS: In ten patients a single voxel was placed over the FCD and in nine patients over the region of interest (ROI) as indicated by MEG. In all patients a voxel was also placed in the contralateral homologus location. We used metabolite concentrations as peak ratios relative to the creatine (Cr) peak to calculate a lateralisation index. RESULTS: In both groups NAA/Cr was significantly lower on the affected side whereas the results for Cho/Cr were more diverse. There were no significant differences between the two groups. The limitations of the used methods and the implications of the findings are discussed.},
   keywords = {Adult
Aged
Brain/*physiopathology
Brain Mapping/*methods
Diagnosis, Differential
Epilepsy/*diagnosis/physiopathology
Female
Functional Laterality/*physiology
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Magnetoencephalography
Male
Malformations of Cortical Development/*diagnosis/physiopathology
Middle Aged},
   ISSN = {1872-6844 (Electronic)
0920-1211 (Linking)},
   DOI = {10.1016/j.eplepsyres.2009.11.007},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/20022471
https://www.sciencedirect.com/science/article/abs/pii/S0920121109003477?via%3Dihub},
   year = {2010},
   type = {Journal Article}
}

@article{RN138,
   author = {Jansen, J. F. and Koutcher, J. A. and Shukla-Dave, A.},
   title = {Non-invasive imaging of angiogenesis in head and neck squamous cell carcinoma},
   journal = {Angiogenesis},
   volume = {13},
   number = {2},
   pages = {149-60},
   note = {Jansen, Jacobus F A
Koutcher, Jason A
Shukla-Dave, Amita
eng
R01 CA115895/CA/NCI NIH HHS/
R01 CA115895-05/CA/NCI NIH HHS/
1 R01CA115895/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
Review
Germany
2010/04/13 06:00
Angiogenesis. 2010 Jun;13(2):149-60. doi: 10.1007/s10456-010-9167-z. Epub 2010 Apr 11.},
   abstract = {Squamous cell carcinoma of the head and neck (HNSCC) is the seventh most common cancer in the United States. Angiogenesis, the process by which new blood vessels are formed, is an essential element at the basis of both tumor growth and metastases. This review discusses pertinent aspects of the role of imaging modalities in assessing angiogenesis and anti-angiogenic therapy in advanced HNSCC.},
   keywords = {Animals
Carcinoma, Squamous Cell/*blood supply
Diagnostic Imaging/*methods
Head and Neck Neoplasms/*blood supply
Humans
Neovascularization, Pathologic/*diagnosis/therapy},
   ISSN = {1573-7209 (Electronic)
0969-6970 (Linking)},
   DOI = {10.1007/s10456-010-9167-z},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/20383743
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912423/pdf/nihms197308.pdf},
   year = {2010},
   type = {Journal Article}
}

@article{RN139,
   author = {Jansen, J. F. and Schoder, H. and Lee, N. Y. and Wang, Y. and Pfister, D. G. and Fury, M. G. and Stambuk, H. E. and Humm, J. L. and Koutcher, J. A. and Shukla-Dave, A.},
   title = {Noninvasive assessment of tumor microenvironment using dynamic contrast-enhanced magnetic resonance imaging and 18F-fluoromisonidazole positron emission tomography imaging in neck nodal metastases},
   journal = {Int J Radiat Oncol Biol Phys},
   volume = {77},
   number = {5},
   pages = {1403-10},
   note = {Jansen, Jacobus F A
Schoder, Heiko
Lee, Nancy Y
Wang, Ya
Pfister, David G
Fury, Matthew G
Stambuk, Hilda E
Humm, John L
Koutcher, Jason A
Shukla-Dave, Amita
eng
R01 CA115895/CA/NCI NIH HHS/
R01 CA115895-04/CA/NCI NIH HHS/
1 R01 CA115895/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
2009/11/13 06:00
Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1403-10. doi: 10.1016/j.ijrobp.2009.07.009. Epub 2009 Nov 10.},
   abstract = {PURPOSE: To assess noninvasively the tumor microenvironment of neck nodal metastases in patients with head-and-neck cancer by investigating the relationship between tumor perfusion measured using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and hypoxia measured by (18)F-fluoromisonidazole ((18)F-FMISO) positron emission tomography (PET). METHODS AND MATERIALS: Thirteen newly diagnosed head-and-neck cancer patients with metastatic neck nodes underwent DCE-MRI and (18)F-FMISO PET imaging before chemotherapy and radiotherapy. The matched regions of interests from both modalities were analyzed. To examine the correlations between DCE-MRI parameters and standard uptake value (SUV) measurements from (18)F-FMISO PET, the nonparametric Spearman correlation coefficient was calculated. Furthermore, DCE-MRI parameters were compared between nodes with (18)F-FMISO uptake and nodes with no (18)F-FMISO uptake using Mann-Whitney U tests. RESULTS: For the 13 patients, a total of 18 nodes were analyzed. The nodal size strongly correlated with the (18)F-FMISO SUV (rho = 0.74, p < 0.001). There was a strong negative correlation between the median k(ep) (redistribution rate constant) value (rho = -0.58, p = 0.042) and the (18)F-FMISO SUV. Hypoxic nodes (moderate to severe (18)F-FMISO uptake) had significantly lower median K(trans) (volume transfer constant) (p = 0.049) and median k(ep) (p = 0.027) values than did nonhypoxic nodes (no (18)F-FMISO uptake). CONCLUSION: This initial evaluation of the preliminary results support the hypothesis that in metastatic neck lymph nodes, hypoxic nodes are poorly perfused (i.e., have significantly lower K(trans) and k(ep) values) compared with nonhypoxic nodes.},
   keywords = {Aged
Aged, 80 and over
*Carcinoma, Squamous Cell/diagnostic imaging/metabolism/pathology
*Cell Hypoxia/physiology
Female
*Head and Neck Neoplasms/diagnostic imaging/metabolism/pathology
Humans
*Lymph Nodes/diagnostic imaging/metabolism/pathology
Lymphatic Metastasis
Magnetic Resonance Imaging/*methods
Male
Middle Aged
Misonidazole/analogs & derivatives/pharmacokinetics
Positron-Emission Tomography/*methods
Radiopharmaceuticals/pharmacokinetics
Retrospective Studies
Statistics, Nonparametric},
   ISSN = {1879-355X (Electronic)
0360-3016 (Linking)},
   DOI = {10.1016/j.ijrobp.2009.07.009},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/19906496
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888682/pdf/nihms132225.pdf},
   year = {2010},
   type = {Journal Article}
}

@article{RN140,
   author = {Jansen, J. F. and Stambuk, H. E. and Koutcher, J. A. and Shukla-Dave, A.},
   title = {Non-gaussian analysis of diffusion-weighted MR imaging in head and neck squamous cell carcinoma: A feasibility study},
   journal = {AJNR Am J Neuroradiol},
   volume = {31},
   number = {4},
   pages = {741-8},
   note = {Jansen, J F A
Stambuk, H E
Koutcher, J A
Shukla-Dave, A
eng
R01 CA115895/CA/NCI NIH HHS/
R01 CA115895-04/CA/NCI NIH HHS/
2009/12/29 06:00
AJNR Am J Neuroradiol. 2010 Apr;31(4):741-8. doi: 10.3174/ajnr.A1919. Epub 2009 Dec 24.},
   abstract = {BACKGROUND AND PURPOSE: Water in biological structures often displays non-Gaussian diffusion behavior. The objective of this study was to test the feasibility of non-Gaussian fitting by using the kurtosis model of the signal intensity decay curves obtained from DWI by using an extended range of b-values in studies of phantoms and HNSCC. MATERIALS AND METHODS: Seventeen patients with HNSCC underwent DWI by using 6 b-factors (0, 50-1500 s/mm(2)) at 1.5T. Monoexponential (yielding ADC(mono)) and non-Gaussian kurtosis (yielding apparent diffusion coefficient D(app) and apparent kurtosis coefficient K(app)) fits were performed on a voxel-by-voxel basis in selected regions of interest (primary tumors, metastatic lymph nodes, and spinal cord). DWI studies were also performed on phantoms containing either water or homogenized asparagus. To determine whether the kurtosis model provided a significantly better fit than did the monoexponential model, an F test was performed. Spearman correlation coefficients were calculated to assess correlations between K(app) and D(app). RESULTS: The kurtosis model fit the experimental data points significantly better than did the monoexponential model (P < .05). D(app) was approximately twice the value of ADC(mono) (eg, in neck nodal metastases D(app) was 1.54 and ADC(mono) was 0.84). K(app) showed a weak Spearman correlation with D(app) in a homogenized asparagus phantom and for 44% of tumor lesions. CONCLUSIONS: The use of kurtosis modeling to fit DWI data acquired by using an extended b-value range in HNSCC is feasible and yields a significantly better fit of the data than does monoexponential modeling. It also provides an additional parameter, K(app), potentially with added value.},
   keywords = {Adult
Aged
Aged, 80 and over
Algorithms
Carcinoma, Squamous Cell/*diagnosis
Diffusion Magnetic Resonance Imaging/*methods
Feasibility Studies
Female
Humans
Image Processing, Computer-Assisted/*methods
Lymphatic Metastasis/pathology
Male
Middle Aged
Normal Distribution
Otorhinolaryngologic Neoplasms/*diagnosis
Phantoms, Imaging
Software
Spinal Cord/pathology},
   ISSN = {1936-959X (Electronic)
0195-6108 (Linking)},
   DOI = {10.3174/ajnr.A1919},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/20037133
http://www.ajnr.org/content/ajnr/31/4/741.full.pdf},
   year = {2010},
   type = {Journal Article}
}

@article{RN141,
   author = {Vaessen, M. J. and Hofman, P. A. and Tijssen, H. N. and Aldenkamp, A. P. and Jansen, J. F. and Backes, W. H.},
   title = {The effect and reproducibility of different clinical DTI gradient sets on small world brain connectivity measures},
   journal = {Neuroimage},
   volume = {51},
   number = {3},
   pages = {1106-16},
   note = {Vaessen, M J
Hofman, P A M
Tijssen, H N
Aldenkamp, A P
Jansen, J F A
Backes, W H
eng
Research Support, Non-U.S. Gov't
2010/03/17 06:00
Neuroimage. 2010 Jul 1;51(3):1106-16. doi: 10.1016/j.neuroimage.2010.03.011. Epub 2010 Mar 11.},
   abstract = {Advances in computational network analysis have enabled the characterization of topological properties in large scale networks including the human brain. Information on structural networks in the brain can be obtained in-vivo by performing tractography on diffusion tensor imaging (DTI) data. However, little is known about the reproducibility of network properties derived from whole brain tractography data, which has important consequences for minimally detectable abnormalities or changes over time. Moreover, acquisition parameters, such as the number of gradient directions and gradient strength, possibly influence network metrics and the corresponding reproducibility derived from tractography data. The aim of the present study is twofold: (i) to determine the effect of several clinically available DTI sampling schemes, differing in number of gradient directions and gradient amplitude, on small world metrics and (ii) to evaluate the interscan reproducibility of small world metrics. DTI experiments were conducted on six healthy volunteers scanned twice. Probabilistic tractography was performed to reconstruct structural connections between regions defined from an anatomical atlas. The observed reproducibility of the network measures was high, reflected by low values for the coefficient of variation (<3.8%), advocating the use of graph theoretical measurements to study neurological diseases. Small world metrics were dependent on the choice of DTI gradient scheme and showed stronger connectivity with increasing directional resolution. The interscan reproducibility was not dependent on the gradient scheme. These findings should be considered when comparing results across studies using different gradient schemes or designing new studies.},
   keywords = {Adult
*Algorithms
Brain/*anatomy & histology
Diffusion Magnetic Resonance Imaging/*methods
Female
Humans
Image Enhancement/methods
Image Interpretation, Computer-Assisted/*methods
Male
Nerve Net/*anatomy & histology
Neural Pathways/*anatomy & histology
Reproducibility of Results
Sensitivity and Specificity},
   ISSN = {1095-9572 (Electronic)
1053-8119 (Linking)},
   DOI = {10.1016/j.neuroimage.2010.03.011},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/20226864
https://www.sciencedirect.com/science/article/abs/pii/S1053811910002818?via%3Dihub},
   year = {2010},
   type = {Journal Article}
}

@article{RN142,
   author = {van den Biggelaar, F. J. and Smolders, J. and Jansen, J. F.},
   title = {Complementary and alternative medicine in alopecia areata},
   journal = {Am J Clin Dermatol},
   volume = {11},
   number = {1},
   pages = {11-20},
   note = {van den Biggelaar, Frank J H M
Smolders, Joost
Jansen, Jacobus F A
eng
Review
New Zealand
2009/12/17 06:00
Am J Clin Dermatol. 2010;11(1):11-20. doi: 10.2165/11530040-000000000-00000.},
   abstract = {Alopecia areata is an unpredictable hair-loss condition. As there is no cure for alopecia areata and no effective conventional therapy, a substantial number of alopecia areata patients resort to complementary and alternative medical remedies and therapies (CAM). This review on the application of CAM in alopecia areata addresses two pertinent aspects. First, it provides a current overview of the published medical literature on CAM used in alopecia areata, and alopecia areata-related studies. Second, it presents a thorough assessment of the considerations and limitations of the use of CAM for the treatment of alopecia areata. A systematic MEDLINE search yielded 13 studies of the clinical use of CAM in the management of alopecia areata, all belonging to one of the five main categories of CAM. Methodological quality was analyzed using objective assessment scores (Wilson and Lawrence scores). Unfortunately, no study was of sufficient internal validity to provide robust evidence of the benefit of CAM. This might be attributable to several specific disease characteristics of alopecia areata, which require an especially solid trial design to properly assess the therapeutic effects of CAM. The review concludes with some recommendations for improving the quality of trials incorporating CAM in the treatment of alopecia areata.},
   keywords = {Alopecia Areata/*therapy
Complementary Therapies/*methods
Evidence-Based Medicine
Humans
Practice Guidelines as Topic
Treatment Outcome},
   ISSN = {1175-0561 (Print)
1175-0561 (Linking)},
   DOI = {10.2165/11530040-000000000-00000},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/20000871
https://link.springer.com/article/10.2165%2F11530040-000000000-00000},
   year = {2010},
   type = {Journal Article}
}

@article{RN143,
   author = {Vlooswijk, M. C. and Jansen, J. F. and de Krom, M. C. and Majoie, H. M. and Hofman, P. A. and Backes, W. H. and Aldenkamp, A. P.},
   title = {Functional MRI in chronic epilepsy: associations with cognitive impairment},
   journal = {Lancet Neurol},
   volume = {9},
   number = {10},
   pages = {1018-27},
   note = {Vlooswijk, Marielle Cg
Jansen, Jacobus Fa
de Krom, Marc Cftm
Majoie, Hj Marian
Hofman, Paul Am
Backes, Walter H
Aldenkamp, Albert P
eng
Research Support, Non-U.S. Gov't
Review
England
2010/08/17 06:00
Lancet Neurol. 2010 Oct;9(10):1018-27. doi: 10.1016/S1474-4422(10)70180-0. Epub 2010 Aug 12.},
   abstract = {Chronic epilepsy is frequently accompanied by serious cognitive side-effects. Clinical factors are important, but cannot account entirely for this cognitive comorbidity. Therefore, research is focusing on the underlying cerebral mechanisms to understand the development of cognitive dysfunction. In the past two decades, functional MRI techniques have been applied extensively to the study of cognitive impairment in chronic epilepsy. However, because of wide variation in study designs, analysis methods, and data presentation, interpretation of these studies has become increasingly difficult for clinicians. In patients with localisation-related epilepsy, whether findings of functional MRI represent the underlying neuronal substrate for cognitive decline remains a subject of debate.},
   keywords = {Animals
Chronic Disease
Cognition Disorders/*diagnosis/etiology/psychology
Epilepsy/complications/*diagnosis/psychology
Humans
Magnetic Resonance Imaging/*methods},
   ISSN = {1474-4465 (Electronic)
1474-4422 (Linking)},
   DOI = {10.1016/S1474-4422(10)70180-0},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/20708970
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(10)70180-0/fulltext},
   year = {2010},
   type = {Journal Article}
}

@article{RN144,
   author = {Vlooswijk, M. C. and Jansen, J. F. and Majoie, H. J. and Hofman, P. A. and de Krom, M. C. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Functional connectivity and language impairment in cryptogenic localization-related epilepsy},
   journal = {Neurology},
   volume = {75},
   number = {5},
   pages = {395-402},
   note = {Vlooswijk, M C G
Jansen, J F A
Majoie, H J M
Hofman, P A M
de Krom, M C T F M
Aldenkamp, A P
Backes, W H
eng
Research Support, Non-U.S. Gov't
2010/08/04 06:00
Neurology. 2010 Aug 3;75(5):395-402. doi: 10.1212/WNL.0b013e3181ebdd3e.},
   abstract = {BACKGROUND: An often underestimated cognitive morbidity in patients with epilepsy is language dysfunction. To investigate the neuronal mechanisms underlying neuropsychological language impairment, activation maps and functional connectivity networks were studied by fMRI of language. METHOD: Fifty-two patients with cryptogenic localization-related epilepsy and 27 healthy controls underwent neuropsychological assessment of IQ, word fluency, and text reading. fMRI was performed with a standard covert word-generation and text-reading paradigm. Functional connectivity analysis comprised cross-correlation of signal time series of the characteristic and most strongly activated regions involved in the language tasks. RESULTS: After careful selection, 34 patients and 20 healthy controls were found eligible for analysis. Patients displayed lower IQ, lower fluency word count, and lower number of words correctly read compared to controls. fMRI activation maps did not differ significantly between patients and controls. For the word-generation paradigm, patients with epilepsy had significantly lower functional connectivity than controls in the prefrontal network. Patients performing worse on the word-fluency test demonstrated a significantly lower mean functional connectivity than controls. Text reading demonstrated lower functional connectivity in patients with epilepsy in the frontotemporal network. Similarly, lower mean functional connectivity was observed in patients with lowest reading performance compared to controls. A relation between reduced functional connectivity and performance on word-fluency and text-reading tests was demonstrated in epilepsy patients. CONCLUSION: Impaired performance on language assessment in epilepsy patients is associated with loss of functional connectivity in the cognitive language networks.},
   keywords = {Adolescent
Adult
Brain/*physiopathology
Brain Mapping
Case-Control Studies
Epilepsies, Partial/*physiopathology
Female
Humans
Intelligence
Intelligence Tests
Language
Language Disorders/*physiopathology
Language Tests
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways/physiopathology
Neuropsychological Tests
Reading
Signal Processing, Computer-Assisted
Young Adult},
   ISSN = {1526-632X (Electronic)
0028-3878 (Linking)},
   DOI = {10.1212/WNL.0b013e3181ebdd3e},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/20679633
https://n.neurology.org/content/75/5/395.long},
   year = {2010},
   type = {Journal Article}
}

@article{RN135,
   author = {Jeukens, C. R. and Vlooswijk, M. C. and Majoie, H. J. and de Krom, M. C. and Aldenkamp, A. P. and Hofman, P. A. and Jansen, J. F. and Backes, W. H.},
   title = {Hippocampal MRI volumetry at 3 Tesla: reliability and practical guidance},
   journal = {Invest Radiol},
   volume = {44},
   number = {9},
   pages = {509-17},
   note = {Jeukens, Cecile R L P N
Vlooswijk, Marielle C G
Majoie, H J Marian
de Krom, Marc C T F M
Aldenkamp, Albert P
Hofman, Paul A M
Jansen, Jacobus F A
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2009/08/21 09:00
Invest Radiol. 2009 Sep;44(9):509-17. doi: 10.1097/RLI.0b013e3181b4c180.},
   abstract = {OBJECTIVES: Although volumetry of the hippocampus is considered to be an established technique, protocols reported in literature are not described in great detail. This article provides a complete and detailed protocol for hippocampal volumetry applicable to T1-weighted magnetic resonance (MR) images acquired at 3 Tesla, which has become the standard for structural brain research. MATERIALS AND METHODS: The protocol encompasses T1-weighted image acquisition at 3 Tesla, anatomic guidelines for manual hippocampus delineation, requirements of delineation software, reliability measures, and criteria to assess and ensure sufficient reliability. Moreover, the validity of the correction for total intracranial volume size was critically assessed. The protocol was applied by 2 readers to the MR images of 36 patients with cryptogenic localization-related epilepsy, 4 patients with unilateral hippocampal sclerosis, and 20 healthy control subjects. RESULTS: The uncorrected hippocampal volumes were 2923 +/- 500 mm3 (mean +/- SD) (left) and 3120 +/- 416 mm3 (right) for the patient group and 3185 +/- 411 mm3 (left) and 3302 +/- 411 mm3 (right) for the healthy control group. The volume of the 4 pathologic hippocampi of the patients with unilateral hippocampal sclerosis was 2980 +/- 422 mm3. The inter-reader reliability values were determined: intraclass-correlation-coefficient (ICC) = 0.87 (left) and 0.86 (right), percentage volume difference (VD) = 7.0 +/- 4.7% (left) and 6.0 +/- 3.8% (right), and overlap ratio (OR) = 0.82 +/- 0.04 (left) and 0.82 +/- 0.03 (right). The positive Pearson correlation between hippocampal volume and total intracranial volume was found to be low: r = 0.48 (P = 0.03, left) and r = 0.62 (P = 0.004, right) and did not significantly reduce the volumetric variances, showing the limited benefit of the brain size correction. CONCLUSIONS: A protocol was described to determine hippocampal volumes based on 3 Tesla MR images with high inter-reader reliability. Although the reliability of hippocampal volumetry at 3 Tesla was similar to the literature values obtained at 1.5 Tesla, hippocampal border definition is argued to be more confident and easier because of the improved signal-to-noise characteristics.},
   keywords = {Adult
*Algorithms
Epilepsy/*diagnosis
Female
Hippocampus/*pathology
Humans
Image Enhancement/*methods
Image Interpretation, Computer-Assisted/*methods
Imaging, Three-Dimensional/*methods
Magnetic Resonance Imaging/*methods
Middle Aged
Reproducibility of Results
Sensitivity and Specificity},
   ISSN = {1536-0210 (Electronic)
0020-9996 (Linking)},
   DOI = {10.1097/RLI.0b013e3181b4c180},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/19692839},
   year = {2009},
   type = {Journal Article}
}

@article{RN136,
   author = {Tijssen, R. H. and Jansen, J. F. and Backes, W. H.},
   title = {Assessing and minimizing the effects of noise and motion in clinical DTI at 3 T},
   journal = {Hum Brain Mapp},
   volume = {30},
   number = {8},
   pages = {2641-55},
   note = {Tijssen, Rob H N
Jansen, Jacobus F A
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2008/12/17 09:00
Hum Brain Mapp. 2009 Aug;30(8):2641-55. doi: 10.1002/hbm.20695.},
   abstract = {Compared with conventional MRI, diffusion tensor imaging (DTI) is more prone to thermal noise and motion. Optimized sampling schemes have been proposed that reduce the propagation of noise. At 3 T, however, motion may play a more dominant role than noise. Although the effects of noise at 3 T are less compared with 1.5 T because of the higher signal-to-noise ratio, motion is independent of field strength and will persist. To improve the reliability of clinical DTI at 3 T, it is important to know to what extent noise and motion contribute to the uncertainties of the DTI indices. In this study, the effects of noise- and motion-related signal uncertainties are disentangled using in vivo measurements and computer simulations. For six clinically standard available sampling schemes, the reproducibility was assessed in vivo, with and without motion correction applied. Additionally, motion and noise simulations were performed to determine the relative contributions of motion and noise to the uncertainties of the mean diffusivity (MD) and fractional anisotropy (FA). It is shown that the contributions of noise and motion are of the same order of magnitude at 3 T. Similar to the propagation of noise, the propagation of motion-related signal perturbations is also influenced by the choice of sampling scheme. Sampling schemes with only six diffusion directions demonstrated a lower reproducibility compared with schemes with 15 and 32 directions and feature a positive bias for the FA in relatively isotropic tissue. Motion correction helps improving the precision and accuracy of DTI indices.},
   keywords = {Adult
Algorithms
Anisotropy
*Artifacts
Brain/anatomy & histology
Computer Simulation
Diffusion Magnetic Resonance Imaging/*methods
Female
Humans
Male
Monte Carlo Method
*Motion
Reproducibility of Results
Uncertainty
Young Adult},
   ISSN = {1097-0193 (Electronic)
1065-9471 (Linking)},
   DOI = {10.1002/hbm.20695},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/19086023
https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.20695},
   year = {2009},
   type = {Journal Article}
}

@article{RN129,
   author = {Jansen, J. F.},
   title = {Statin therapy and cognitive deficits associated with neurofibromatosis type 1},
   journal = {JAMA},
   volume = {300},
   number = {20},
   pages = {2369; author reply 2369-70},
   note = {Jansen, Jacobus F A
eng
Comment
Letter
2008/11/27 09:00
JAMA. 2008 Nov 26;300(20):2369; author reply 2369-70. doi: 10.1001/jama.2008.687.},
   keywords = {Animals
Child
Cognition/*drug effects
Disease Models, Animal
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
Mice
Mice, Neurologic Mutants
Neurofibromatosis 1/*drug therapy
Simvastatin/*therapeutic use},
   ISSN = {1538-3598 (Electronic)
0098-7484 (Linking)},
   DOI = {10.1001/jama.2008.687},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/19033585
https://jamanetwork.com/journals/jama/article-abstract/182959},
   year = {2008},
   type = {Journal Article}
}

@article{RN130,
   author = {Jansen, J. F. and Gearhart, J. D. and Bulte, J. W.},
   title = {Comment on "Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain"},
   journal = {Science},
   volume = {321},
   number = {5889},
   pages = {640},
   note = {Jansen, Jacobus F A
Gearhart, John D
Bulte, Jeff W M
eng
Comment
2008/08/02 09:00
Science. 2008 Aug 1;321(5889):640. doi: 10.1126/science.1153997.},
   abstract = {Manganas et al. (Reports, 9 November 2007, p. 980) reported the discovery of a biomarker specific for neural progenitor cells detectable using magnetic resonance spectroscopy. A new algorithm was developed to extract the biomarker from noisy in vivo data. We question how this algorithm was validated, because the biomarker overlaps with peaks from nonspecific lipid signals.},
   keywords = {Algorithms
Animals
Biomarkers/*analysis
Brain/*cytology
Embryonic Stem Cells/chemistry/cytology
Humans
Lipids/*analysis
Magnetic Resonance Spectroscopy/*methods
Mice
Neurons/chemistry/*cytology
Stem Cells/chemistry/*cytology},
   ISSN = {1095-9203 (Electronic)
0036-8075 (Linking)},
   DOI = {10.1126/science.1153997},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/18669846
https://science.sciencemag.org/content/sci/321/5889/640.4.full.pdf},
   year = {2008},
   type = {Journal Article}
}

@article{RN131,
   author = {Jansen, J. F. and Lemmens, E. M. and Strijkers, G. J. and Prompers, J. J. and Schijns, O. E. and Kooi, M. E. and Beuls, E. A. and Nicolay, K. and Backes, W. H. and Hoogland, G.},
   title = {Short- and long-term limbic abnormalities after experimental febrile seizures},
   journal = {Neurobiol Dis},
   volume = {32},
   number = {2},
   pages = {293-301},
   note = {Jansen, Jacobus F A
Lemmens, Evi M P
Strijkers, Gustav J
Prompers, Jeanine J
Schijns, Olaf E M G
Kooi, M Eline
Beuls, Emile A M
Nicolay, Klaas
Backes, Walter H
Hoogland, Govert
eng
2008/08/19 09:00
Neurobiol Dis. 2008 Nov;32(2):293-301. doi: 10.1016/j.nbd.2008.07.010. Epub 2008 Jul 27.},
   abstract = {Experimental febrile seizures (FS) are known to promote hyperexcitability of the limbic system and increase the risk for eventual temporal lobe epilepsy (TLE). Early markers of accompanying microstructural and metabolic changes may be provided by in vivo serial MRI. FS were induced in 9-day old rats by hyperthermia. Quantitative multimodal MRI was applied 24 h and 8 weeks later, in rats with FS and age-matched controls, and comprised hippocampal volumetry and proton spectroscopy, and cerebral T2 relaxometry and diffusion tensor imaging (DTI). At 9 weeks histology was performed. Hippocampal T2 relaxation time elevations appeared to be transient. DTI abnormalities detected in the amygdala persisted up to 8 weeks. Hippocampal volumes were not affected. Histology showed increased fiber density and anisotropy in the hippocampus, and reduced neuronal surface area in the amygdala. Quantitative serial MRI is able to detect transient, and most importantly, long-term FS-induced changes that reflect microstructural alterations.},
   keywords = {Animals
Diffusion Magnetic Resonance Imaging/methods
Disease Models, Animal
Follow-Up Studies
Hippocampus/*pathology/*physiopathology
Hyperthermia, Induced/adverse effects
Image Processing, Computer-Assisted
Magnetic Resonance Imaging/methods
Magnetic Resonance Spectroscopy
Neural Pathways/pathology
Protons
Rats
Rats, Sprague-Dawley
Seizures, Febrile/etiology/metabolism/*pathology
Time Factors},
   ISSN = {1095-953X (Electronic)
0969-9961 (Linking)},
   DOI = {10.1016/j.nbd.2008.07.010},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/18707002
https://www.sciencedirect.com/science/article/abs/pii/S0969996108001666?via%3Dihub},
   year = {2008},
   type = {Journal Article}
}

@article{RN132,
   author = {Jansen, J. F. and Vlooswijk, M. C. and de Baets, M. H. and de Krom, M. C. and Rieckmann, P. and Backes, W. H. and Aldenkamp, A. P. and Group, Segaed Study},
   title = {Cognitive fMRI and soluble telencephalin assessment in patients with localization-related epilepsy},
   journal = {Acta Neurol Scand},
   volume = {118},
   number = {4},
   pages = {232-9},
   note = {Jansen, J F A
Vlooswijk, M C G
de Baets, M H
de Krom, M C T F M
Rieckmann, P
Backes, W H
Aldenkamp, A P
eng
Denmark
2008/05/08 09:00
Acta Neurol Scand. 2008 Oct;118(4):232-9. doi: 10.1111/j.1600-0404.2008.01005.x. Epub 2008 Apr 30.},
   abstract = {Objectives - The use of telencephalin as a possible marker for altered cortical function as demonstrated by functional MRI was investigated in a pilot study with 16 patients with localization-related epilepsy and secondarily generalized seizures. Materials and methods - Functional MRI of verbal working memory performance (Sternberg paradigm) and self-regulatory control processes (Stroop paradigm) was used to examine cortical activation in 16 patients with localization-related epilepsy and secondarily generalized seizures. Additionally, blood serum concentrations of soluble telencephalin (marker for neuronal damage) were determined. Results - In three patients (one temporal and two frontal focus), telencephalin was detected. All three patients had lower functional MRI activation in the frontotemporal region (P = 0.04), but not in other regions (P > 0.35) compared with patients without detectable telencephalin. Additionally, an association of levetiracetam and frontotemporal activation was observed. Conclusions - These preliminary data in a heterogeneous group suggest an association between decreased frontotemporal activation on fMRI and both detectable telencephalin serum levels and levetiracetam use. Future longitudinal studies with larger patient groups are required to confirm these observations. It is hypothesized that altered local function of the frontotemporal cortex in localization-related epilepsy might be better predicted by the biochemical marker telencephalin than epilepsy characteristics such as seizure focus.},
   keywords = {Adult
Anticonvulsants/therapeutic use
Biomarkers/blood
Brain/drug effects/*pathology
Cell Adhesion Molecules/*blood
Epilepsies, Partial/*blood/drug therapy/*pathology
Female
Humans
Levetiracetam
*Magnetic Resonance Imaging
Male
Middle Aged
Nerve Tissue Proteins/*blood
Neuropsychological Tests
Pilot Projects
Piracetam/analogs & derivatives/therapeutic use},
   ISSN = {1600-0404 (Electronic)
0001-6314 (Linking)},
   DOI = {10.1111/j.1600-0404.2008.01005.x},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/18460045
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0404.2008.01005.x},
   year = {2008},
   type = {Journal Article}
}

@article{RN133,
   author = {Jansen, J. F. and Vlooswijk, M. C. and Majoie, H. M. and de Krom, M. C. and Aldenkamp, A. P. and Hofman, P. A. and Backes, W. H.},
   title = {White matter lesions in patients with localization-related epilepsy},
   journal = {Invest Radiol},
   volume = {43},
   number = {8},
   pages = {552-8},
   note = {Jansen, Jacobus F A
Vlooswijk, Marielle C G
Majoie, Hj Marian
de Krom, Marc C T F M
Aldenkamp, Albert P
Hofman, Paul A M
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2008/07/24 09:00
Invest Radiol. 2008 Aug;43(8):552-8. doi: 10.1097/RLI.0b013e31817e90d2.},
   abstract = {OBJECTIVES: White matter lesions (WML) have been proven to be associated with cognitive impairment. As (1) the decline of cognitive function is the most frequent comorbid disorder in epilepsy, and (2) patients with epilepsy have a relatively high prevalence of WML, the question is raised whether WML in patients with epilepsy are also associated with cognitive decline. MATERIALS AND METHODS: A high-resolution magnetic resonance imaging examination was performed at 3.0 T, comprising T1-weighted, T2 relaxometry, and fluid-attenuated inversion recovery (FLAIR) sequences. Patients with localization-related epilepsy with impaired and unimpaired cognitive functioning and a healthy control group were included. Furthermore, the performance of an automated WML detection algorithm, based on regional intensity evaluation, was assessed. RESULTS: The prevalence of WML, detected on 3.0 T FLAIR images, is 63% in healthy volunteers and 46% in patients with localization-related, cryptogenic epilepsy. No relationship between WML volume and cognitive performance was observed. The WML volumes from the automated segmentation method were found to be significantly correlated to the volumes obtained by neuroradiologic assessment. CONCLUSIONS: No relations could be found between WML and cognition in the well-defined population of patients with epilepsy. Other clinical characteristics of chronic epilepsy, such as seizures, age of onset, and medication are more likely to play an important role in cognitive decline. Furthermore, the automated WML detection algorithm using a regional Z-score analysis can successfully segment and quantify the WML on FLAIR images.},
   keywords = {Adult
Algorithms
Cognition Disorders/*diagnosis
Epilepsies, Partial/*diagnosis
Female
Humans
Image Processing, Computer-Assisted
*Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests},
   ISSN = {1536-0210 (Electronic)
0020-9996 (Linking)},
   DOI = {10.1097/RLI.0b013e31817e90d2},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/18648254},
   year = {2008},
   type = {Journal Article}
}

@article{RN235,
   author = {Langers, D. R. and Jansen, J. F. and Backes, W. H.},
   title = {Erratum to “Enhanced signal detection in neuroimaging by means of regional control of the global false discovery rate” [NeuroImage 38 (2007) 43–56]},
   journal = {Neuroimage},
   volume = {40},
   number = {4},
   pages = {1930},
   note = {Langers, Dave R M
Jansen, Jacobus F A
Backes, Walter H
eng},
   abstract = {Due to a typesetting error, the index under “min” in Eq. (5) is incorrect.},
   keywords = {Adult
*Algorithms
Brain/*physiology
Brain Mapping/*methods
Evoked Potentials/*physiology
False Positive Reactions
Female
Humans
Image Enhancement/*methods
Image Interpretation, Computer-Assisted/*methods
Magnetic Resonance Imaging/*methods
Male
Reproducibility of Results
Sensitivity and Specificity
Signal Processing, Computer-Assisted},
   ISSN = {1053-8119 (Print)
1053-8119 (Linking)},
   DOI = {10.1016/j.neuroimage.2008.01.036},
   url = {https://www.sciencedirect.com/science/article/pii/S1053811908001018
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   year = {2008},
   type = {Journal Article}
}

@article{RN134,
   author = {Vlooswijk, M. C. and Jansen, J. F. and Reijs, R. P. and de Krom, M. C. and Kooi, M. E. and Majoie, H. J. and Hofman, P. A. and Backes, W. H. and Aldenkamp, A. P.},
   title = {Cognitive fMRI and neuropsychological assessment in patients with secondarily generalized seizures},
   journal = {Clin Neurol Neurosurg},
   volume = {110},
   number = {5},
   pages = {441-50},
   note = {Vlooswijk, Marielle C G
Jansen, Jacobus F A
Reijs, Rianne P
de Krom, Marc C T F M
Kooi, M Eline
Majoie, H J Marian
Hofman, Paul A M
Backes, Walter H
Aldenkamp, Albert P
eng
Netherlands
2008/03/15 09:00
Clin Neurol Neurosurg. 2008 May;110(5):441-50. doi: 10.1016/j.clineuro.2008.01.007. Epub 2008 Mar 12.},
   abstract = {OBJECTIVES: Cognitive dysfunction is a frequent comorbid disorder in epilepsy which has been associated with high seizure frequency. We examined the effect of secondarily generalized tonic-clonic seizures (SGTCS) on cognitive dysfunction using neuropsychological assessment and fMRI. PATIENTS AND METHODS: Sixteen patients with localization-related epilepsy of varying etiologies and SGTCS underwent extensive neuropsychological assessment. Functional MRI was performed probing the frontal and temporal lobes with two paradigms aimed at investigating speed of mental processing and working memory. RESULTS: A high number of total lifetime SGTCS was associated with lower intelligence scores. Moreover, a trend towards cognitive decline related to the number of SGTCS was observed. A relatively increased prefrontal activation related to the number of SGTCS was demonstrated, plus a trend towards a decreased activation in the frontotemporal areas. CONCLUSION: High numbers of SGTCS are associated with a drop in intelligence scores and altered prefrontal brain activation. A shift from frontotemporal to prefrontal activation seems to have occurred, suggesting that a functional reorganization of working memory is induced by a high number of SGTCS. It remains uncertain if this reorganization reflects a compensation mechanism, or the underlying pathological processes of cognitive dysfunction.},
   keywords = {Adult
*Brain Mapping
Cognition Disorders/*complications/diagnosis
Epilepsy, Tonic-Clonic/*complications/physiopathology
Female
Frontal Lobe/physiopathology
Humans
Intelligence Tests
Linear Models
Magnetic Resonance Imaging
Male
Memory, Short-Term
Middle Aged
Neuropsychological Tests
Prefrontal Cortex/*physiopathology
Problem Solving
Seizures/*complications/physiopathology
Temporal Lobe/physiopathology},
   ISSN = {0303-8467 (Print)
0303-8467 (Linking)},
   DOI = {10.1016/j.clineuro.2008.01.007},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/18339478
https://www.sciencedirect.com/science/article/abs/pii/S030384670800019X?via%3Dihub},
   year = {2008},
   type = {Journal Article}
}

@article{RN127,
   author = {Jansen, J. F. and Kooi, M. E. and Kessels, A. G. and Nicolay, K. and Backes, W. H.},
   title = {Reproducibility of quantitative cerebral T2 relaxometry, diffusion tensor imaging, and 1H magnetic resonance spectroscopy at 3.0 Tesla},
   journal = {Invest Radiol},
   volume = {42},
   number = {6},
   pages = {327-37},
   note = {Jansen, Jacobus F A
Kooi, M Eline
Kessels, Alfons G H
Nicolay, Klaas
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2007/05/18 09:00
Invest Radiol. 2007 Jun;42(6):327-37. doi: 10.1097/01.rli.0000262757.10271.e5.},
   abstract = {OBJECTIVES: The reproducibility of quantitative cerebral T2 relaxometry, diffusion tensor imaging, and H magnetic resonance (MR) spectroscopic imaging was assessed on a clinical 3.0 T MR system. MATERIALS AND METHODS: Repeated measurements in 10 healthy volunteers were used to establish the reproducibility of quantitative measures derived from different quantitative MR techniques, namely the T2 relaxation time, the apparent diffusion coefficient (ADC), the fractional anisotropy (FA), and metabolite concentrations of N-acetyl-aspartate (NAA), creatine (Cr), choline (Cho), and myo-inositol (mI). Results were compared with previously reported reproducibility measures from 1.5 T. RESULTS: The coefficient of variation (CV) was < or =1.6% for T2, < or =1.6% for ADC, and < or =5.3%, for FA in the cerebrum. For metabolites the CV was < or =8.0% in the frontal lobe and < or =20.4% in the temporal lobe. CONCLUSIONS: The reproducibility of quantitative brain MRI at 3.0 T is better than or at least comparable to the reproducibility at 1.5 T.},
   keywords = {Adult
Anisotropy
Aspartic Acid/analogs & derivatives/metabolism
*Brain Chemistry
Brain Mapping/*methods
Choline/metabolism
Creatine/metabolism
Data Interpretation, Statistical
Diffusion Magnetic Resonance Imaging/*methods
Female
Humans
Image Processing, Computer-Assisted
Inositol/metabolism
Magnetic Resonance Spectroscopy/*methods
Male
Reference Values
Reproducibility of Results},
   ISSN = {0020-9996 (Print)
0020-9996 (Linking)},
   DOI = {10.1097/01.rli.0000262757.10271.e5},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/17507802},
   year = {2007},
   type = {Journal Article}
}

@article{RN128,
   author = {Langers, D. R. and Jansen, J. F. and Backes, W. H.},
   title = {Enhanced signal detection in neuroimaging by means of regional control of the global false discovery rate},
   journal = {Neuroimage},
   volume = {38},
   number = {1},
   pages = {43-56},
   note = {Langers, Dave R M
Jansen, Jacobus F A
Backes, Walter H
eng
Evaluation Study
2007/09/11 09:00
Neuroimage. 2007 Oct 15;38(1):43-56. doi: 10.1016/j.neuroimage.2007.07.031. Epub 2007 Aug 8.},
   abstract = {In the context of neuroimaging experiments, it is essential to account for the multiple comparisons problem when thresholding statistical mappings. Various methods are in use to deal with this issue, but they differ in their signal detection power for small- and large-scale effects. In this paper, we comprehensively describe a new method that is based on control of the false discovery rate (FDR). Our method increases sensitivity by exploiting the spatially clustered nature of neuroimaging effects. This is achieved by using a sliding window technique, in which FDR-control is first applied at a regional level. Thus, a new statistical map that is related to the regionally achieved FDR is derived from the available voxelwise P-values. On the basis of receiver operating characteristic (ROC) curves, thresholding based on this map is demonstrated to have better discriminatory power than conventional thresholding based on P-values. Secondly, it is shown that the resulting maps can be thresholded at a level that results in control of the global FDR. By means of statistical arguments and numerical simulations under widely varying conditions, our method is validated, characterized, and compared to some other common voxel-based methods (uncorrected thresholding, Bonferroni correction, and conventional FDR-control). It is found that our method shows considerably higher sensitivity as compared to conventional FDR-control, while still controlling the achieved FDR at the same level or better. Finally, our method is applied to two diverse neuroimaging experiments to assess its practical merits, resulting in substantial improvements as compared to the other methods.},
   keywords = {Adult
*Algorithms
Brain/*physiology
Brain Mapping/*methods
Evoked Potentials/*physiology
False Positive Reactions
Female
Humans
Image Enhancement/*methods
Image Interpretation, Computer-Assisted/*methods
Magnetic Resonance Imaging/*methods
Male
Reproducibility of Results
Sensitivity and Specificity
Signal Processing, Computer-Assisted},
   ISSN = {1053-8119 (Print)
1053-8119 (Linking)},
   DOI = {10.1016/j.neuroimage.2007.07.031},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/17825583
https://www.sciencedirect.com/science/article/abs/pii/S1053811907006775?via%3Dihub},
   year = {2007},
   type = {Journal Article}
}

@article{RN124,
   author = {Jansen, J. F. and Aldenkamp, A. P. and Marian Majoie, H. J. and Reijs, R. P. and de Krom, M. C. and Hofman, P. A. and Eline Kooi, M. and Nicolay, K. and Backes, W. H.},
   title = {Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy},
   journal = {Epilepsy Behav},
   volume = {9},
   number = {1},
   pages = {181-5},
   note = {Jansen, Jacobus F A
Aldenkamp, Albert P
Marian Majoie, H J
Reijs, Rianne P
de Krom, Marc C T F M
Hofman, Paul A M
Eline Kooi, M
Nicolay, Klaas
Backes, Walter H
eng
2006/06/24 09:00
Epilepsy Behav. 2006 Aug;9(1):181-5. doi: 10.1016/j.yebeh.2006.05.004. Epub 2006 Jun 21.},
   abstract = {Functional magnetic resonance imaging of covert word generation was used to examine brain activation abnormalities associated with topiramate-induced cognitive language impairment in patients with epilepsy. Compared with a control epilepsy group, in the topiramate-treated group, there was significantly less activation in the language-mediating regions of the prefrontal cortex; the topiramate group also had significantly lower neuropsychological language scores. These findings suggest that topiramate has a critical effect on the cerebral neural systems that mediate expressive language.},
   keywords = {Adult
Anticonvulsants/adverse effects/*pharmacology/therapeutic use
Cognition/drug effects
Epilepsy/drug therapy/*physiopathology
Female
Fructose/adverse effects/*analogs & derivatives/pharmacology/therapeutic use
Humans
Language Disorders/*chemically induced/physiopathology
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Prefrontal Cortex/*drug effects/physiopathology
Topiramate},
   ISSN = {1525-5050 (Print)
1525-5050 (Linking)},
   DOI = {10.1016/j.yebeh.2006.05.004},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/16793345
https://www.epilepsybehavior.com/article/S1525-5050(06)00183-1/fulltext
https://www.epilepsybehavior.com/article/S1525-5050(06)00183-1/pdf},
   year = {2006},
   type = {Journal Article}
}

@article{RN125,
   author = {Jansen, J. F. and Backes, W. H. and Nicolay, K. and Kooi, M. E.},
   title = {1H MR spectroscopy of the brain: absolute quantification of metabolites},
   journal = {Radiology},
   volume = {240},
   number = {2},
   pages = {318-32},
   note = {Jansen, Jacobus F A
Backes, Walter H
Nicolay, Klaas
Kooi, M Eline
eng
Review
2006/07/26 09:00
Radiology. 2006 Aug;240(2):318-32. doi: 10.1148/radiol.2402050314.},
   abstract = {Hydrogen 1 (1H) magnetic resonance (MR) spectroscopy enables noninvasive in vivo quantification of metabolite concentrations in the brain. Currently, metabolite concentrations are most often presented as ratios (eg, relative to creatine) rather than as absolute concentrations. Despite the success of this approach, it has recently been suggested that relative quantification may introduce substantial errors and can lead to misinterpretation of spectral data and to erroneous metabolite values. The present review discusses relevant methods to obtain absolute metabolite concentrations with a clinical MR system by using single-voxel spectroscopy or chemical shift imaging. Important methodological aspects in an absolute quantification strategy are addressed, including radiofrequency coil properties, calibration procedures, spectral fitting methods, cerebrospinal fluid content correction, macromolecule suppression, and spectral editing. Techniques to obtain absolute concentrations are now available and can be successfully applied in clinical practice. Although the present review is focused on 1H MR spectroscopy of the brain, a large part of the methodology described can be applied to other tissues as well.},
   keywords = {Brain/*metabolism
*Brain Chemistry
Calibration
Humans
Magnetic Resonance Spectroscopy/instrumentation/*methods
Signal Processing, Computer-Assisted
Statistics as Topic},
   ISSN = {0033-8419 (Print)
0033-8419 (Linking)},
   DOI = {10.1148/radiol.2402050314},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/16864664},
   year = {2006},
   type = {Journal Article}
}

@article{RN126,
   author = {Jansen, J. F. and Shamblott, M. J. and van Zijl, P. C. and Lehtimaki, K. K. and Bulte, J. W. and Gearhart, J. D. and Hakumaki, J. M.},
   title = {Stem cell profiling by nuclear magnetic resonance spectroscopy},
   journal = {Magn Reson Med},
   volume = {56},
   number = {3},
   pages = {666-70},
   note = {Jansen, Jacobus F A
Shamblott, Michael J
van Zijl, Peter C M
Lehtimaki, Kimmo K
Bulte, Jeff W M
Gearhart, John D
Hakumaki, Juhana M
eng
P41 EB015909/EB/NIBIB NIH HHS/
R01 NS045062/NS/NINDS NIH HHS/
RR11115/RR/NCRR NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
2006/07/22 09:00
Magn Reson Med. 2006 Sep;56(3):666-70. doi: 10.1002/mrm.20968.},
   abstract = {The classification of embryonic and adult stem cells, including their derivatives, is still limited, and often these cells are best defined by their functional properties. Recent gene array studies have yielded contradictory results. Also, very little is known about the metabolic properties of these exciting cells. In this study, proton (1H) NMR spectroscopy was used to identify the major low-molecular-weight metabolites in murine embryonic stem cells (ESC) and their neural stem cell (NSC) derivatives. ESC are characterized by an unusually low number of NMR-detectable metabolites, high phosphocholine (PC) content, and nondetectable glycerophosphocholine (GPC). The metabolic profiles of NSC resemble glial cells and oligodendrocyte progenitors, but with considerably higher PC, GPC, and myo-inositol content. The results suggest that NMR spectroscopy in vitro can provide markers to study the effects of differentiation on cell metabolism, and potentially to assess stem cell preparations for differentiation status.},
   keywords = {Animals
Cell Line
Magnetic Resonance Spectroscopy/*methods
Mice
Neurons/*cytology/*metabolism
Phosphorylcholine/*analysis
Stem Cells/*cytology/*metabolism},
   ISSN = {0740-3194 (Print)
0740-3194 (Linking)},
   DOI = {10.1002/mrm.20968},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/16858672
https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.20968},
   year = {2006},
   type = {Journal Article}
}

@article{RN123,
   author = {van Ingen, H. and Lasonder, E. and Jansen, J. F. and Kaan, A. M. and Spronk, C. A. and Stunnenberg, H. G. and Vuister, G. W.},
   title = {Extension of the binding motif of the Sin3 interacting domain of the Mad family proteins},
   journal = {Biochemistry},
   volume = {43},
   number = {1},
   pages = {46-54},
   note = {van Ingen, Hugo
Lasonder, Edwin
Jansen, Jacobus F A
Kaan, Anita M
Spronk, Christian A E M
Stunnenberg, Henk G
Vuister, Geerten W
eng
Comparative Study
Research Support, Non-U.S. Gov't
2004/01/07 05:00
Biochemistry. 2004 Jan 13;43(1):46-54. doi: 10.1021/bi0355645.},
   abstract = {Sin3 forms the scaffold for a multiprotein corepressor complex that silences transcription via the action of histone deacetylases. Sin3 is recruited to the DNA by several DNA binding repressors, such as the helix-loop-helix proteins of the Mad family. Here, we elaborate on the Mad-Sin3 interaction based on a binding study, solution structure, and dynamics of the PAH2 domain of mSin3 in complex to an extended Sin3 interacting domain (SID) of 24 residues of Mad1. We show that SID residues Met7 and Glu23, outside the previously defined minimal binding motif, mediate additional hydrophobic and electrostatic interactions with PAH2. On the basis of these results we propose an extended consensus sequence describing the PAH2-SID interaction specifically for the Mad family, showing that residues outside the hydrophobic core of the SID interact with PAH2 and modulate binding affinity to appropriate levels.},
   keywords = {Amino Acid Motifs
Amino Acid Sequence
Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Caenorhabditis elegans Proteins/chemistry
Conserved Sequence
Crystallography, X-Ray
DNA-Binding Proteins/*chemistry
Fungal Proteins/chemistry
Histone Deacetylases
Humans
Membrane Proteins/chemistry
Molecular Sequence Data
Multigene Family
Nuclear Magnetic Resonance, Biomolecular
Protein Binding
Protein Structure, Tertiary
*Repressor Proteins
*Saccharomyces cerevisiae Proteins
Sequence Alignment
*Sequence Homology, Amino Acid
Solutions
Surface Plasmon Resonance
Thermodynamics
Transcription Factors/*chemistry},
   ISSN = {0006-2960 (Print)
0006-2960 (Linking)},
   DOI = {10.1021/bi0355645},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/14705930
https://pubs.acs.org/doi/10.1021/bi0355645},
   year = {2004},
   type = {Journal Article}
}

@article{RN122,
   author = {Spronk, C. A. and Jansen, J. F. and Tessari, M. and Kaan, A. M. and Aelen, J. and Lasonder, E. and Stunnenberg, H. G. and Vuister, G. W.},
   title = {Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1},
   journal = {J Biomol NMR},
   volume = {19},
   number = {4},
   pages = {377-8},
   note = {Spronk, C A
Jansen, J F
Tessari, M
Kaan, A M
Aelen, J
Lasonder, E
Stunnenberg, H G
Vuister, G W
eng
Letter
Research Support, Non-U.S. Gov't
Netherlands
2001/05/24 10:00
J Biomol NMR. 2001 Apr;19(4):377-8. doi: 10.1023/a:1011262214741.},
   keywords = {Amino Acid Sequence
Animals
Cell Cycle Proteins
Chromatin/chemistry
Magnetic Resonance Spectroscopy/*methods
Mice
Molecular Sequence Data
Nuclear Proteins
Phosphoproteins/*chemistry
Protein Conformation
Protein Structure, Tertiary
Repressor Proteins/*chemistry
Sequence Homology, Amino Acid
*Transcription Factors},
   ISSN = {0925-2738 (Print)
0925-2738 (Linking)},
   DOI = {10.1023/a:1011262214741},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/11370785
https://link.springer.com/article/10.1023/A:1011262214741},
   year = {2001},
   type = {Journal Article}
}

@article{RN121,
   author = {Spronk, C. A. and Tessari, M. and Kaan, A. M. and Jansen, J. F. and Vermeulen, M. and Stunnenberg, H. G. and Vuister, G. W.},
   title = {The Mad1-Sin3B interaction involves a novel helical fold},
   journal = {Nat Struct Biol},
   volume = {7},
   number = {12},
   pages = {1100-4},
   note = {Spronk, C A
Tessari, M
Kaan, A M
Jansen, J F
Vermeulen, M
Stunnenberg, H G
Vuister, G W
eng
Research Support, Non-U.S. Gov't
2000/12/02 11:00
Nat Struct Biol. 2000 Dec;7(12):1100-4. doi: 10.1038/81944.},
   abstract = {Sin3A or Sin3B are components of a corepressor complex that mediates repression by transcription factors such as the helix-loop-helix proteins Mad and Mxi. Members of the Mad/Mxi family of repressors play important roles in the transition between proliferation and differentiation by down-regulating the expression of genes that are activated by the proto-oncogene product Myc. Here, we report the solution structure of the second paired amphipathic helix (PAH) domain (PAH2) of Sin3B in complex with a peptide comprising the N-terminal region of Mad1. This complex exhibits a novel interaction fold for which we propose the name 'wedged helical bundle'. Four alpha-helices of PAH2 form a hydrophobic cleft that accommodates an amphipathic Mad1 alpha-helix. Our data further show that, upon binding Mad1, secondary structure elements of PAH2 are stabilized. The PAH2-Mad1 structure provides the basis for determining the principles of protein interaction and selectivity involving PAH domains.},
   keywords = {Amino Acid Sequence
Animals
Binding Sites
*Carrier Proteins
Cell Cycle Proteins
Conserved Sequence
Humans
Mice
Models, Molecular
Molecular Sequence Data
Nuclear Magnetic Resonance, Biomolecular
*Nuclear Proteins
Phosphoproteins/*chemistry/*metabolism
Protein Binding
Protein Structure, Secondary
Protein Structure, Tertiary
Repressor Proteins/*chemistry/*metabolism
Sequence Alignment
Solutions
Substrate Specificity
*Transcription Factors},
   ISSN = {1072-8368 (Print)
1072-8368 (Linking)},
   DOI = {10.1038/81944},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/11101889
https://www.nature.com/articles/nsb1200_1100},
   year = {2000},
   type = {Journal Article}
}